Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice

Liu, Weifeng; Huang, Huimin; Niu, Xiaofeng; Fan, Ting; Mu, Qingli; Li, Huani

doi:10.1016/j.taap.2013.05.035

Cited by 107 publications

(77 citation statements)

References 44 publications

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“…Gastrointestinal problems have now become a global problem, and the gastric ulcer model induced by ethanol in mice is usually used to assess the gastroprotective activity of the drugs [17]. It has been reported that some pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) are involved in the pathogenesis of acute gastric lesions [18,19,20]. Nuclear factor-kappa B (NF-κB) is a classic pro-inflammatory transcription factor and plays a central role in regulating inflammatory, immune, and anti-apoptotic processes.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Anti-Ulcer Efficacy of Sanguinarine Loaded Solid Lipid Nanoparticles

Sun¹,

Liu

et al. 2017

Pharmacology

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Aim: This study was designed to develop sanguinarine-loaded solid lipid nanoparticles (SG-SLNs) and investigate its gastroprotective effect on ethanol-induced gastric mucosal lesions in mice. Methods: SG-SLNs were prepared by high temperature melt-cool solidification method using glycerol monostearate as the lipid and a combination of lecithin with poloxamer 188 as the surfactants. Solid lipid nanoparticles (SLNs) were designed at varying lipid concentrations (5, 10, 15, and 20 mg/mL), surfactant mixture concentrations (6, 12, and 18 mg/mL), and drug contents (5, 10, 15, and 20 mg/mL) in “one factor at a time” fashion. Ethanol-induced gastric ulcer model was performed on Kunming mice to examine the anti-inflammatory activity of SG-SLNs and compare it with sanguinarine (SG). Results: The high temperature melt-cool solidification method provided consistent production of SLNs with smaller size and high entrapment efficiency (EE%). The composition of optimal formulation was 10 mg/mL lipid concentration, 18 mg/mL surfactant mixture concentration, and 15 mg/mL drug amount. The mean particle size and EE% of optimized formulation were 238 ± 10.9 nm and 79 ± 2.8%, respectively. Additionally, SG-SLNs significantly decreased tumor necrosis factor-alpha and interleukin-6 levels in the serum and gastric tissue, and reduced the content of NO in serum, and strengthened the protection of mucosal membrane. Moreover, SG-SLNs treatment markedly inhibited ethanol-induced nuclear factor-kappa B (NF-κB) activation when compared with SG. Conclusions: SLNs could be potentially applied as a delivery system of SG. The protective effect of SG-SLNs is due to the suppression of NF-κB expression and subsequent pro-inflammatory cytokines release.

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Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Anti-Ulcer Efficacy of Sanguinarine Loaded Solid Lipid Nanoparticles

Sun¹,

Liu

et al. 2017

Pharmacology

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“…Accordingly, single dose of ethanol was selected for the present study. Long term administration of ethanol is another option to be studied, as performed by Li et al (23). Ethanol induced gastric injury models possess various limitations, including the differences between the doses and concentrations of ethanol that is preferred by authors.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions

Karakaya¹,

Barut²,

Hancı³

et al. 2015

BLL

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Abstract:Introduction: Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q 10 (CoQ 10 ) supplementation on the ethanol-induced gastric mucosal damage in a rat model. Material and method: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ 10 at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrifi ced and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. Results and discussion: Rats pretreated either with famotidine or CoQ 10 had signifi cantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were signifi cantly lower in famotidine 20 mg/kg and CoQ 10 pretreatment for 7 days group (p < 0.00625). Conclusion: CoQ 10 affords gastroprotection against ethanol-induced gastric mucosal lesions in rats especially after repetitive administrations (Tab. 3, Fig. 2, Ref. 35). Text in PDF www.elis.sk.

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“…Wine processing caused an increase in all tertiary alkaloids [protopine (1), α-allocryptopine (2), tetrahydrocolumbamine (3), tetrahydropalmatine (8), tetrahydroberberine (9), corydaline (10), tetrahydrocoptisine (11)] in the water decoction of JLZS. These compounds reported bioactivities such as antinociceptive, antithrombotic, antifibrillatory and antiinflammatory effects [38][39][40]. Hence, the claimed positive influence of wine processing on the properties of the drug could be justified.…”

Section: Influence Of Vinegar and Wine Processing On The Alkaloid Conmentioning

confidence: 99%

Influence of Vinegar and Wine Processing on the Alkaloid Content and Composition of the Traditional Chinese Medicine Corydalis Rhizoma (Yanhusuo)

Waldbauer

Tang

et al. 2014

Molecules

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Corydalis Rhizoma is the dried tuber of Corydalis yanhusuo W.T. Wang which is used in traditional Chinese medicine for pain relief and blood activation. Before being used in the clinics, C. yanhusuo is traditionally processed through dry-frying or frying with vinegar, wine or salt. In this study, eleven alkaloids from Corydalis Rhizoma, namely protopine (1), α-allocryptopine (2), tetrahydrocolumbamine (3), coptisine (4), palmatine (5), berberine (6), dehydrocorydaline (7), D,L-tetrahydropalmatine (8), tetrahydroberberine (9), corydaline (10) and tetrahydrocoptisine (11) were simultaneously quantified using a newly developed high performance liquid chromatography-diode array detector (HPLC-DAD) method. The influence of vinegar and wine processing on the content of the main alkaloids of Corydalis Rhizoma was investigated. For this purpose, two common formulations with clinical application, namely the water decoction of Corydalis Rhizoma and its formula Jin Ling Zi San (combination of Corydalis Rhizoma and Toosendan Fructus) were studied. In the two water decoctions, wine and vinegar processing increased the amount of tertiary alkaloids. The differences were more pronounced for Jin Ling Zi San, in which case the content of all tertiary alkaloids (compounds 1, 2, 3, 8, 9, 10, 11) was increased by wine processing.

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Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice

Cited by 107 publications

References 44 publications

Preparation, Characterization and Anti-Ulcer Efficacy of Sanguinarine Loaded Solid Lipid Nanoparticles

Preparation, Characterization and Anti-Ulcer Efficacy of Sanguinarine Loaded Solid Lipid Nanoparticles

Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions

Influence of Vinegar and Wine Processing on the Alkaloid Content and Composition of the Traditional Chinese Medicine Corydalis Rhizoma (Yanhusuo)

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