Protective effect of Thai silk extracts on drug-induced phototoxicity in human epidermal A431 cells and a reconstructed human epidermis model

Rosena, Apiwan; Koobkokkruad, Thongchai; Eaknai, Waleewan; Bunwatcharaphansakun, Phichaporn; Maniratanachote, Rawiwan; Aueviriyavit, Sasitorn

doi:10.1016/j.jphotobiol.2018.08.022

Cited by 5 publications

(3 citation statements)

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“…Sericin from different sources exhibited varying antioxidant capacities, possibly due to flavonoids and polyphenols. In addition, treatment with enriched silk extracts has been found to reduce the number of apoptotic cells in a drug-induced phototoxicity cell model, compared to chlorpromazine, and significantly attenuated the release of IL-1α [143].…”

Section: Silkmentioning

confidence: 99%

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Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes

Haller,

Sander,

Nischwitz

et al. 2023

Preprint

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Although a slight imbalance between oxidative and antioxidative mediators is part of normal physiology that enables cell aging and the removal of dead cells, burns disturb this equilibrium locally and systemically. Topical burn dressings may attenuate local and systemic oxidative stress and positively influence the post-burn clinical course. This review integrated knowledge regarding the impact of burn dressings on oxidative stress. Using keywords and in-text searches, literature was identified from PubMed, Google Scholar, and Google articles, and studies on local or topical applications of wound dressings and associated oxidative stress were selected. As im-balances between oxidative mediators and antioxidative agents significantly contribute to organ dysfunction and healing disturbance, we investigated oxidative stress on organs, metabolic changes, clinical results, and oxidative parameters influenced by applied dressings. We found positive local and systemic effects of external burn dressings in laboratory and animal tests; however, such studies were rare in humans. Nevertheless, we identified successful cases of semi-occlusive, occlusive, and biologically active dressings that reduce oxidative stress in hu-man burns. In particular, we highlight promising clinical and laboratory results from lac-tate-releasing dressings. Our review provides an invaluable resource for future development and clinical applications of burn dressings.

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Section: Silkmentioning

confidence: 99%

“…Moreover, silk sericin has been shown to induce pro-oxidative stress and trigger apoptosis in human cancer cells [144]. However, treatment with enriched silk extracts has been found to reduce the number of apoptotic cells, compared to chlorpromazine, in a drug-induced phototoxicity cell model and significantly attenuated IL-1α release [143].…”

Section: Silkmentioning

confidence: 99%

Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes

Haller,

Sander,

Nischwitz

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Recently, oral polypodium leucotomos extract, a known antioxidant, has also been used in some patients to mitigate phototoxic reactions [ 225 ]. Additionally, one study found that Thai silk extracts enriched with sericin protein have a protective effect on drug-induced phototoxicity in skin cells, which could have potential applications in the development of novel skincare products [ 226 ]. However, more evidence is needed on the efficacy of polypodium and Thai silk extracts before it can be recommended.…”

Section: Diagnosis and Managementmentioning

confidence: 99%