2005
DOI: 10.1016/j.burns.2005.04.013
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Protective effect of trapidil against oxidative organ damage in burn injury

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Cited by 13 publications
(3 citation statements)
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“…During analysis of colon for myeloperoxidase (MPO) content, we found evidence of a marked reduction of leukocytes in colon of thermally injured mice. Others investigators using a similar thermal injury model in rats have shown that intestinal myeloperoxidase was significantly increased after burn, but these measurements were made early (3 and 24 h) after injury [21]. In the present study, burned mice had lower baseline intestinal MPO levels but appeared capable of dramatic leukocyte recruitment after LPS injection, while previously sham injured mice showed no increase in leukocyte content after LPS injection.…”
Section: Discussioncontrasting
confidence: 55%
“…During analysis of colon for myeloperoxidase (MPO) content, we found evidence of a marked reduction of leukocytes in colon of thermally injured mice. Others investigators using a similar thermal injury model in rats have shown that intestinal myeloperoxidase was significantly increased after burn, but these measurements were made early (3 and 24 h) after injury [21]. In the present study, burned mice had lower baseline intestinal MPO levels but appeared capable of dramatic leukocyte recruitment after LPS injection, while previously sham injured mice showed no increase in leukocyte content after LPS injection.…”
Section: Discussioncontrasting
confidence: 55%
“…Other compounds with remarkably good anti-oxidative and anti-inflammatory effects have been studied for the purpose of reducing the inflammatory effects of the oxidative stress on pulmonary tissue, among which pentoxifylline [115], apocynin-nitrone [116], narginin [117], sphingisylphosphorylcholine [118], usnic acid [119], zinc aspartate [120], trapidil [121] or melatonin [122].…”
Section: Therapy With Antioxidantsmentioning
confidence: 99%
“…[17,[19][20][21][22][23][24] Effects of different agents on oxidative damage due to severe burn injury were evaluated in remote organs such as the lung, liver, gut and kidney in previous studies. [4,9,[25][26][27][28] Sildenafil is known as a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase-5 (PDE-5). PDE-5 catalyzes the hydrolysis of cGMP.…”
Section: Introductionmentioning
confidence: 99%