Protective effect of U-74389G on paraquat induced pneumotoxicity in rats

Shopova, Veneta; Dancheva, Violeta; Salovsky, Pencho; Stoyanova, A.; Lukanov, Tzvetan

doi:10.1016/j.etap.2007.04.010

Cited by 7 publications

(5 citation statements)

References 26 publications

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“…It is a very dangerous pollutant of the environment, as it readily binds to both clay and organic matter in soil and is very slowly biodegraded. [1] This acute poisoning is common method of suicide in India. [2] Poisoning due to this chemical is observed because of the easy availability, improper storage methods and lack of awareness of the potential harm.…”

Section: Introductionmentioning

confidence: 99%

Demographics, clinical characteristics and management of herbicide poisoning in tertiary care hospital

Cherukuri¹,

Pramoda²,

Rohini³

et al. 2014

Toxicol Int

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Herbicide poisoning is most common method of suicide in India and it is associated with high morbidity and mortality. Among different herbicidal poisonings the most predominantly found poisonings are paraquat and glyphosate. These compounds are highly toxic and their poisonings require proper management techniques. High fatality is seen in these cases which are mainly due to its inherent toxicity and lack of effective treatment. Common symptoms of these poisonings includes gastrointestinal corrosive effects with mouth and throat, epigastric pain and dysphagia, acid-base imbalance, pulmonary edema, shock and arrhythmia. Long term health effects include pulmonary fibrosis, renal failure, hepatic failure, heart failure, multi-organ failure or death. No proven antidote exists for these poisonings. So the treatment is mainly supportive. Initially gastric lavage or whole-gut irrigation using adsorbents such as Fuller's earth, bentonite or activated charcoal is recommended. In case of renal failure hemodialysis or hemoperfusion may be considered. However novel approaches like treatment with N-acetylcysteine, vitamin C, vitamin E, cyclophosphamide may also be helpful.

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Section: Introductionmentioning

confidence: 99%

Demographics, clinical characteristics and management of herbicide poisoning in tertiary care hospital

Cherukuri¹,

Pramoda²,

Rohini³

et al. 2014

Toxicol Int

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“…Shopova VL et al estimated the protective effects of the lazaroid U-74389G possessing antilipid peroxidation activity and membrane-stabilizing effect in male Wistar rats [13].…”

Section: Discussionmentioning

confidence: 99%

The effect of the antioxidant drug “U-74389G” on acid phosphatase levels during ischemia reperfusion injury in rats

Τsompos¹

2016

Appl Med Res

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Introduction: This experimental study examined the effect of the antioxidant drug “U-74389G”, on a rat model and particularly in an ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean acid phosphatase (ACP) levels. Methods: 40 rats of mean weight 231.875 g were used in the study. ACP levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). Administration of the drug U-74389G was predicted only for groups C and D. Results: U-74389G administration significantly decreased the ACP levels by 128.45% ±14.84% (p= 0.0000). Reperfusion time non-significantly decreased the ACP levels by 22.44% ± 25.86% (p= 0.2000). However, U-74389G administration and reperfusion time together significantly decreased the ACP levels by 74.45% ± 9.63% (p= 0.0000). Conclusions: U-74389G administration whether it interacted or not with reperfusion time, offers spectacular significant decreasing short – term effects on ACP levels.

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“…Also, LDH levels may be influenced by U-74389G administration. Shopova VL et al [19] considered that paraquat forms reactive oxygen species and increases the lipid peroxidation in the pulmonary cells. Paraquat dichloride was administered orally at 80mg/kg in Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

The Effect of the Antioxidant Drug “U-74389G” on Lactate Dehydrogenase Levels during Ischemia Reperfusion Injury in Rats

Tsompos¹

2016

JAPLR

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Background: This experimental study examined the effect of the antioxidant drug "U-74389G", on a rat model and particularly in a generalized ischemiareperfusion protocol. The effects of that molecule were studied biochemically using blood mean lactate dehydrogenase (LDH) levels.Methods: 40 rats of mean weight 231.875 g were used in the study. LDH levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D.Results: U-74389G administration kept significantly increased the predicted LDH levels by 18.78%+4.52% (P= 0.0001). Reperfusion time non-significantly decreased the predicted LDH levels by 3.75%+5.46% (p=0.4103). However, U-74389G administration and reperfusion time together kept significantly increased the predicted LDH levels by 10.43%+2.82% (P= 0.0005).

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Protective effect of U-74389G on paraquat induced pneumotoxicity in rats

Cited by 7 publications

References 26 publications

Demographics, clinical characteristics and management of herbicide poisoning in tertiary care hospital

Demographics, clinical characteristics and management of herbicide poisoning in tertiary care hospital

The effect of the antioxidant drug “U-74389G” on acid phosphatase levels during ischemia reperfusion injury in rats

The Effect of the Antioxidant Drug “U-74389G” on Lactate Dehydrogenase Levels during Ischemia Reperfusion Injury in Rats

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