Protective effect of vitamin E against carbendazim-induced testicular toxicity–histopathological evidences and reduced residue levels in testis and serum

Rajeswary, S; Mathew, Nisha; Akbarsha, Mohammad Abdulkader; Kalyanasundram, Muthuswamy; Kumaran, B.

doi:10.1007/s00204-007-0204-7

Cited by 17 publications

(9 citation statements)

References 14 publications

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“…also suggested that exposure of rats to mancozeb at a dose level of 313.6 mg/kg body weight (bw) (1/10th of LD 50 ) resulted in histological alterations in the testis accompanied by decreased testosterone biosynthesis. Earlier it has been reported that carbamate fungicides induce oxidative stress and causes DNA damage in fibroblast cells and reproductive impairment in rats . A common strategy for reduction of tissue toxicity against reactive oxygen species (ROS) is the use of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Forskolin ameliorates mancozeb‐induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis

Girish

Reddy

2017

J Biochem & Molecular Tox

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In the present study, we have tested the beneficial effects of forskolin in protecting the mancozeb-induced reproductive toxicity in rats. Adult male Wistar rats were exposed to either mancozeb (500 mg/kg body weight/day) or forskolin (5 mg/kg body weight/day) or both for 65 days and analyzed for spermatogenesis and steroidogenesis and testicular and epididymal oxidative toxicity. A significant decrease in daily sperm production, epididymal sperm count, motile, viable, and hypo-osmotic swelling-tail swelled sperm was observed in mancozeb-treated rats. The activity levels of testicular 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase and circulatory testosterone levels were significantly decreased in mancozeb-treated rats. Exposure to mancozeb resulted in a significant decrease in glutathione levels and superoxide dismutase and catalase activity levels with an increase in lipid peroxidation levels in the testes and epididymis. Coadministration of forskolin mitigated the mancozeb-induced oxidative toxicity and suppressed steroidogenesis and spermatogenesis.

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Section: Introductionmentioning

confidence: 99%

Forskolin ameliorates mancozeb‐induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis

Girish

Reddy

2017

J Biochem & Molecular Tox

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“…S5 (http://dx.doi.org/10.14573/altex.1601253s5) with their expression fold change versus untreated cells. and Miller, 1997a;Moffit et al, 2007;Rajeswary et al, 2007;Yu et al, 2009), the concentrations tested (50 and 500 nM) were below the lowest peak plasma concentrations found in the literature, i.e., 13 µM after 24 h in nude mice according to Jia and colleagues (2003). For IPR, the concentrations tested in this report (50 nM and 500 nM) were consistent with the lowest concentrations tested in previous studies (Blystone et al, 2009(Blystone et al, , 2007Perez-Carreon et al, 2009;Washington and Tchounwou, 2004).…”

Section: Fig 8: Comparison Of Differentially Expressed Proteins Identified In Supernatants Of Cells Treated With Each Substancementioning

confidence: 58%

Ex vivo assessment of testicular toxicity induced by carbendazim and iprodione, alone or in a mixture-suppl1.

Pisani

2016

ALTEX

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health problems, such as some cancers, allergies, neurological and reproductive disorders (Mehrpour et al., 2014;Mostafalou and Abdollahi, 2013). In particular, since the middle of the twentieth century in developed countries, studies have reported a significant decrease in human fertility associated with lowered sperm quality and an increase in reproductive diseases such as testicular and ovarian cancers (Jensen et al., 2002). Reduced semen quality seems to be so frequent that it may impair fertility rates (Jorgensen et al., 2012). According to the 2013 report IntroductionThe recent awareness of the residual presence in foods, wines and drinking water of many pesticides requires urgent investigation of their potential toxicities to human health and the environment. Global pesticide consumption has increased steadily since the 1940s and this widespread use of pesticides in a massive manner for many years is now suspected to represent one of the main environmental causative factors related to public

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“…[18] More specifically speaking, these vitamins have been shown to have protective effect on testis and fertility. [4,19] This study was design to evaluate the effect of administration of vitamin C and vitamin E on fertilization capacity of rats exposed to noise stress.…”

Section: Introductionmentioning

confidence: 99%

Effect of administration of vitamins C and E on fertilization capacity of rats exposed to noise stress

et al. 2013

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The aims of this study were to evaluate the effects of administration of Vitamins C and E on fertilization capacity in rats exposed to noise stress. 40 adult male rats were randomly divided into 5 equal groups. Group 1 as controls who were not exposed to noise and groups 2-5 exposed to noise with 90-120 dB intensity and 300-350 Hz frequency from 7 pm to 7 am everyday for 50 days. Group 2 exposed to noise and did not receive Vitamins. Group 3 received vitamin C, Group 4 received Vitamin E. Group 5 received Vitamins C and E concomitantly. After 50 days, serum Follicle-stimulating hormone (FSH), Luteinizing hormone (LH) and testosterone were calculated. Then each rat was left with three female rats for mating. Pregnant females were sacrificed on the 19 th day of pregnancy and evaluated for the presence and number of viable, dead and absorbed fetuses. The level of FSH, LH and testosterone significantly decreased in rats exposed to noise (P < 0.05). By administration of Vitamins in groups 3-5 we observed that the level of hormones significantly increased in compared to group 2 (P < 0.05). The fertilization capacity of male rats in groups 3-5 significantly increased in compared to group 2 (P < 0.05). There was significant difference between groups 1 and 2 in case of fertilization capacity (P = 0.001). The data in this study strongly suggests a negative role for noise stress on level of FSH, LH and testosterone level and also fertilization capacity of male rats. To complement the information it is suggested that this research be done on human samples.

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Protective effect of vitamin E against carbendazim-induced testicular toxicity–histopathological evidences and reduced residue levels in testis and serum

Cited by 17 publications

References 14 publications

Forskolin ameliorates mancozeb‐induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis

Forskolin ameliorates mancozeb‐induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis

Ex vivo assessment of testicular toxicity induced by carbendazim and iprodione, alone or in a mixture-suppl1.

Effect of administration of vitamins C and E on fertilization capacity of rats exposed to noise stress

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