Protective effect of wedelolactone against CCl 4 -induced acute liver injury in mice

Yang, Lu; Hu, Di; Ma, Shanbo; Zhao, Xian; Wang, Shan; W, Guo; Wang, XiFang; Wen, Aidong; Wang, Jingwen

doi:10.1016/j.intimp.2016.02.003

Cited by 84 publications

(65 citation statements)

References 37 publications

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“…Generally, AST and ALT (formerly known as SGOT and SGPT) have been used as serum markers to represent liver damage (Sodikoff, ); these enzymes are markedly elevated in CCl 4 ‐induced hepatic damage (Lu et al., ; Yang et al., ) and were elevated in the CCl 4 control in the present study. Therefore, the results of our study provided further evidence that all three BH extracts tested in this study exerted favorable hepatoprotective effects against CCl 4 ‐induced liver injuries; the strongest effect was induced by BHe, followed by BHj and BHw, as demonstrated by the marked and significant inhibitions on the CCl 4 ‐induced serum AST and ALT elevations in these groups compared with the CCl 4 control.…”

Section: Discussionsupporting

confidence: 52%

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Hepatoprotective effects of blue honeysuckle on CCl₄‐induced acute liver damaged mice

Lee

Cho

Kim³

et al. 2018

Food Science & Nutrition

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The objective of this study was to evaluate the hepatoprotective effects of blue honeysuckle (BH) on carbon tetrachloride (CCl4)‐induced acute hepatic damage in mice. The experiment used a total of 60 ICR mice, which were divided into six groups. Except for the intact control groups, all groups received a single intraperitoneal injection of CCl4 after a 7 day pre‐treatment period with distilled water, BH extracts, or silymarin. Twenty‐four hours after the CCl4 injection, the following observations, representative of classical oxidative stress‐mediated centrolobular necrotic acute liver injuries, were observed: decreased body weight; small nodule formation and enlargement on the gross inspections with related liver weight increase; elevation of serum AST and ALT, increases in hepatic lipid peroxidation and related depletion of endogenous antioxidants and antioxidative enzymes; centrolobular necrosis; increases in apoptotic markers, lipid peroxidation markers, and oxidative stress markers. However, liver damage was significantly inhibited by the pre‐treatment with BH extracts. The present study demonstrated that oral administration of BH extracts prior to exposure to CCl4 conferred favorable hepatoprotective effects. These results demonstrated that BHe possessed suitable properties for use as a potent hepatoprotective medicinal food.

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Section: Discussionsupporting

confidence: 52%

“…The strongest effects were exerted by BHe, followed by silymarin, BHj, and BHw. Generally, AST and ALT (formerly known as SGOT and SGPT) have been used as serum markers to represent liver damage (Sodikoff, 1995); these enzymes are markedly elevated in CCl 4induced hepatic damage (Lu et al, 2016;Yang et al, 2015) and…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of blue honeysuckle on CCl₄‐induced acute liver damaged mice

Lee

Cho

Kim³

et al. 2018

Food Science & Nutrition

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“…Also, the level of Alb decreased. This result is in coincidence with many other results obtained by different authors who used CCl 4 in their experiments (Hassan et al 2003;Hsiao et al 2003;Hismiogullari et al 2014;Kang andKoppula, 2014 andLu et al 2016).…”

Section: Discussionsupporting

confidence: 93%

Histological and biochemical studies on the effect of tetrodotoxin extracted from Puffer fish (Lagocephalus sceleratus) against carbon tetrachloride induced hepatotoxicity in albino mice.

Khalil¹,

Swelim²,

Zaky³

2018

Egypt. J. of Aquatic Biolo. and Fish.

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“…For this reason, traditional and herbal medicine has attracted increasing attention due to its cost-effectiveness and relative safety compared with pharmaceutical drugs (Kalantari et al, 2017). In line with this notion, several studies showed that such traditional medications exert protective role on ALI progression by regulating JNK signaling and oxidative stress-mediated cell death (Chen et al, 2017;Lu et al, 2016).…”

Section: Discussionmentioning

confidence: 98%

Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin‐mediated acute and chronic liver injury in mice

Kim

Yang

Jeong

et al. 2019

Phytotherapy Research

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Acute liver injury (ALI) is a life‐threatening clinical syndrome. Long‐lasting liver injury can lead to chronic hepatic inflammation and fibrogenic responses. Zerumbone (ZER), the main constituent of rhizomes of Zingiber zerumbet Smith, has a variety of functions including anticancer activity. We investigated the role of ZER on the progression of hepatotoxin‐induced liver injury. Single or repeated injection of CCl4 was used to induce acute or chronic liver injury, respectively. Mice were orally administered with ZER (10, 50 mg/kg) during the experimental period. Histopathologic analysis and serum biochemical levels revealed that ZER had hepatoprotective activities against ALI. Similar effects of ZER on injured livers were confirmed by analyses of inflammation and apoptosis‐related genes. Western blot analysis showed that protein levels of apoptotic molecules were decreased, whereas antiapoptotic protein levels were conversely increased in injured livers treated with ZER. Furthermore, chronic liver injury and its associated fibrogenesis in mice were reduced by ZER treatment. These findings from our in vivo experiments further indicate that ZER could alleviate hepatocellular toxicity and inhibit activation of primary hepatic stellate cells. Our results suggest that ZER might have potential as a safe and prophylactic alternative to prevent acute and chronic liver injury.

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Protective effect of wedelolactone against CCl 4 -induced acute liver injury in mice

Cited by 84 publications

References 37 publications

Hepatoprotective effects of blue honeysuckle on CCl₄‐induced acute liver damaged mice

Hepatoprotective effects of blue honeysuckle on CCl₄‐induced acute liver damaged mice

Histological and biochemical studies on the effect of tetrodotoxin extracted from Puffer fish (Lagocephalus sceleratus) against carbon tetrachloride induced hepatotoxicity in albino mice.

Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin‐mediated acute and chronic liver injury in mice

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Protective effect of wedelolactone against CCl 4 -induced acute liver injury in mice

Cited by 84 publications

References 37 publications

Hepatoprotective effects of blue honeysuckle on CCl4‐induced acute liver damaged mice

Hepatoprotective effects of blue honeysuckle on CCl4‐induced acute liver damaged mice

Histological and biochemical studies on the effect of tetrodotoxin extracted from Puffer fish (Lagocephalus sceleratus) against carbon tetrachloride induced hepatotoxicity in albino mice.

Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin‐mediated acute and chronic liver injury in mice

Contact Info

Product

Resources

About

Hepatoprotective effects of blue honeysuckle on CCl₄‐induced acute liver damaged mice

Hepatoprotective effects of blue honeysuckle on CCl₄‐induced acute liver damaged mice