Protective effect of Yemeni green coffee powder against the oxidative stress induced by Ochratoxin A

Nogaim, Qais A.; Bugata, Lakshmi Sai Pratyusha; Pv, Prabhakar; Reddy, Utkarsh A.; P, Mangala Gowri; S, Indu Kumari; Mahboob, M.

doi:10.1016/j.toxrep.2019.11.015

Cited by 26 publications

(12 citation statements)

References 27 publications

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“…Studies have shown that coffee physiologically increases the antioxidant capacity in liver damage. Studies on coffee and caffeine similarly reported that antioxidant parameters increased and oxidant parameters decreased (Amer et al, 2017;Nogaim et al, 2020;Shaposhnikov et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

The Effect of Turkish Coffee on Performance, Biochemical, and Physiological Parameters in Rabbits

Makav

Ölmez

Eroğlu

et al. 2021

Harran Üniversitesi Veteriner Fakültesi Dergisi

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Coffee is one of the most widely consumed hot beverages in the world. Melanoidins, which are formed with brown color during coffee roasting, are reported to be a strong antioxidant. Discussions related to the more and less consumption of coffee still continue. This study investigated the effect of a low and high amount of coffee consumption on antioxidant parameters in this context. A total of 15 female New Zealand rabbits weighing 1500-2500 g were used in the study. The control group was fed as ad-libitum control with basal feed. 1% and 5% Turkish coffee were added to the feed of the 1% TC and 5% TC groups, respectively. Blood was collected once a week throughout the study. All animals were euthanized in accordance with ethical rules at the end of the study. Samples (plasma and tissue) were taken for the analyses. Glutathione (GSH) and malondialdehyde (MDA) analyses were performed on all samples. Plasma GSH values were observed to increase in the groups given TC according to the analyses. Plasma MDA values decreased in the TC groups. An increase was observed in liver and heart tissue in the TC group upon the evaluation of tissue GSH parameters. MDA values were found to decrease in lung, heart, and kidney tissues in TC groups. Additional effects were observed in plasma and tissues in the 5% TC group upon the evaluation of 1% TC and 5% TC groups. No statistical differences were found in performance parameters. It has been revealed as a result that TC is a strong antioxidant, and its effect increases in high consumption.

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Section: Discussionmentioning

confidence: 98%

The Effect of Turkish Coffee on Performance, Biochemical, and Physiological Parameters in Rabbits

Makav

Ölmez

Eroğlu

et al. 2021

Harran Üniversitesi Veteriner Fakültesi Dergisi

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“…A study with tambaqui (Colossoma macropomum), a freshwater fish, found an increase in the ROS and lipid peroxidation in the animal's muscles, as well as a decrease in the activity of antioxidant enzymes superoxide dismutase (SOD) and GPx (Baldissera et al, 2020). Similarly, an increase in lipid peroxidation and antioxidant enzymes activity catalase (CAT) and GR was seen with a decrease in SOD activity and GSH levels in the brain, kidney, and liver of rats (Nogaim et al, 2020). A study found an increase in ROS formation, lipid peroxidation, and decreased GSH levels in kidney cells (Lee et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Ochratoxin A induces behavioral and neurochemical changes in adult zebrafish

Valadas

Sachett

Marcon

et al. 2021

Preprint

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Ochratoxin A (OTA) is a mycotoxin produced by species of filamentous fungi widely found as a contaminant in food and with high toxic potential. Studies have shown that this toxin cause kidney and liver damage, however, data on the effects of exposure to OTA on the central nervous system are still scarce. Zebrafish (Danio rerio) is a teleost often used in translational research due to its physiological, genetic, and behavioral homology with mammals, in addition to being useful as an environmental bioindicator. Thus, this study aimed to investigate the effects of exposure to OTA on behavioral and neurochemical parameters in adult zebrafish. The animals were treated with different doses of OTA (1.38, 2.77, and 5.53 mg/kg) and submitted to behavioral evaluations in the open tank and social interaction tests. Subsequently, they were euthanized, and the brains were used to assess markers associated with oxidative status. In the open tank test OTA induced changes in distance, absolute turn angle, mean speed, and time-freezing. However, no significant effects were observed in the social interaction test. Moreover, OTA also induced alterations in neurochemical parameters with changes in non-protein thiols (NPSH), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and glutathione reductase (GR). This study showed that OTA can affect neurobiological aspects in zebrafish even at low doses.

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“…Cotreatment of Yemeni green coffee suppressed OTA-induced oxidative stress by restoring SOD and glutathione; it reduced rat kidney injury under histopathology. Yemeni green coffee is a functional food which has antioxidant properties against OTA-induced toxicity [ 96 ]. RLE is rich in cyanidin 3-glucoside antioxidant.…”

Section: Preventionmentioning

confidence: 99%

Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence

Khoi

Chen

Lin

et al. 2021

IJMS

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Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.

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Protective effect of Yemeni green coffee powder against the oxidative stress induced by Ochratoxin A

Cited by 26 publications

References 27 publications

The Effect of Turkish Coffee on Performance, Biochemical, and Physiological Parameters in Rabbits

The Effect of Turkish Coffee on Performance, Biochemical, and Physiological Parameters in Rabbits

Ochratoxin A induces behavioral and neurochemical changes in adult zebrafish

Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence

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