Protective effect of zinc supplementation against copper toxicosis in sheep

Bremner, I.; Young, Brian; Mills, Christopher

doi:10.1079/bjn19760108

Cited by 108 publications

(45 citation statements)

References 24 publications

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“…Zn and Cu are mutual antagonist trace elements and there is a competitive biological interaction between them (Bremner et al 1976;Bremner et al 1995). Although changes in the activity of Cu enzymes may occur in animals or in cells exposed to high levels of Zn, it is not certain that Cu in the enzymes is displaced by Zn, rather it seems that the amount of Cu has been reduced.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Hyperbaric Oxygen Treatment on Oxidant and Antioxidants Levels during Liver Regeneration in Rats

Özden

Uzun

Bohloli

et al. 2004

Tohoku J. Exp. Med.

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The effects of hyperbaric oxygen (HBO) therapy on oxidant/antioxidant metabolism are controversial and its effects on hepatic regeneration are not known. In this study, we investigated a possible beneficial effect of HBO therapy on oxidant and antioxidants levels during liver regeneration. To conduct this study, seventy percent hepatectomy was performed on forty-eight SpraggueDawley rats and the rats were divided into two equal groups: HBO-treated group and untreated group (non-HBO group). We determined the levels of malondialdehyde (MDA), an oxidative stress marker, and the levels of antioxidant enzymes/reagents, including glutathione (GSH), superoxide dismutase (SOD) activitiy, copper (Cu) and zinc (Zn), in the remnant liver samples. We also measured mitotic index (MI) and proliferating cell nuclear antigen (PCNA) levels to assess the degree of liver regeneration. HBO treatment significantly decreased MDA levels, whereas it increased SOD activity, GSH and Zn levels. In contrast, Cu levels were lower in the HBO-treated livers than the levels in the untreated remnant livers. The effect of HBO treatment may be mediated by the suppression of certain enzymes that are responsible for lipid peroxidation. In addition, HBO treatment may induce the production of antioxidant enzymes/reagents by remnant liver tissues. The HBO-treated rats maintained their body weights but the untreated rats lost body weights. HBO treatment also increased MI and PCNA levels, indicating HBO treatment enhances liver regeneration. These

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Section: Discussionmentioning

confidence: 99%

The Effects of Hyperbaric Oxygen Treatment on Oxidant and Antioxidants Levels during Liver Regeneration in Rats

Özden

Uzun

Bohloli

et al. 2004

Tohoku J. Exp. Med.

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“…Thus, Zn supplements reduce the incidence of Cu toxicosis in sheep (Bremner et al 1976) and are now used to treat Wilson's disease in humans (Hoogenraad et al 1978;Brewer et al 1983). Brewer et al (1993) have established the optimumdosage regimen to reduce Cu absorption and to restore Cu balance.…”

Section: Discussionmentioning

confidence: 99%

Copper and zinc metabolism in health and disease: speciation and interactions

Bremner¹,

Beattie²

1995

Proc. Nutr. Soc.

137

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It has long been evident that the metabolism of trace elements cannot be considered in isolation. A wide range of nutritional and physiological factors can influence their uptake, transport and storage, with subsequent enhancement of susceptibility to deficiency or toxicity states. Interactions occur with other trace elements and these can be classified as competitive or non-competitive, direct or indirect. However, their physiological or toxicological significance is sometimes debatable, partly because they were demonstrated under extreme experimental conditions where massive doses of the antagonistic metal were administered, often by parenteral routes and to animals whose trace element status was already severely compromised. Our understanding of the mechanisms of the interactions is frequently limited and indeed in only a few cases has it been possible to describe these on a molecular basis.It is almost traditional to cite the early work of Hill & Matrone (1970) as the first serious attempt to describe trace element interactions on a rational basis. They postulated that elements with similar physical or chemical properties will act antagonistically to each other biologically. The implication was that such metals could compete for binding sites on transport proteins or on enzymes requiring metals as co-factors. Over subsequent years, much evidence was produced in support of this view but rarely was the specific site of interaction identified, other than at tissue level. In part this reflected somewhat embarrassing limitations in our knowledge of the proteins involved in the intracellular and extracellular transport and storage of trace metals. 1988). This casts some doubt on the mutuality of the interaction. Most of the early investigations were largely descriptive and they did little to elucidate the precise molecular basis or locus of the interaction.Cu and Zn occupy a similar part of the periodic table, the Zn2+ and Cuf ions being isoelectronic and having similar ionic radii. Both metals readily form chelates with 0-, S-, or N-containing ligands but not always with the same stereochemical arrangement of bonds. However, unlike Zn which occurs in only one valency state, Cu can occur in two, as Cu+ and Cu2+; indeed there have been suggestions that Cu3+ may also have a https://www.cambridge.org/core/terms. https://doi

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“…In addition, when combined with supplements of S and Mo, bentonite might bind the S and Mo supplements in the rumen and decrease their effectiveness in reducing the bioavailability of dietary copper (Ivan et al, 1999). Therefore, the remaining dietary supplements that reduce the dietary Cu bioavailability are Mo, S, Zn and Fe (Dick, 1954;Ross, 1966 and1970;Hogan et al, 1968;Suttle, 1974 and1975;Bremner et al, 1976;Phillipo et al, 1987). Owing to the fact that the concentration of Fe in PKC is known to range between 800 and 6000 mg/kg DM and was 1512 mg/kg DM in the presently used PKC, and that the excessive dietary concentrations of Fe may result in bent legs of lambs (Hidiroglou et al, 1978) and in decreased productivity in dairy cows (Coup and Campbell, 1964), the use of dietary Fe to reduce the bioavailability of dietary Cu was not considered in the present experiment.…”

Section: Discussionmentioning

confidence: 99%

“…It was previously reported that dietary Zn reduced the hepatic Cu accumulation and promoted the formation of relatively non-toxic forms of Cu in the liver, such as metallothionein, which is involved in the storage and detoxification of Cu and other heavy metals (Bremner and Marshall, 1974;Bremner et al, 1976). In the present experiment, the urinary Cu excretion in the Zn-supplemented sheep was almost identical to that of the control group, but the body retention was 26% lower due to the increased fecal Cu excretion.…”

Section: Discussionmentioning

confidence: 99%

“…The fact that treatments with tetrathiomolybdate (Gooneratne et al, 1981), Fe 1 S (Phillipo et al, 1987), Zn (Bremner and Marshall, 1974;Bremner et al, 1976), and with Mo and S alone and in combination (Dick, 1954;Ross 1966 and1970;Hogan et al, 1968;Suttle, 1974 and1975) can decrease the dietary Cu bioavailability and accumulation in the liver has been known for decades. More recently, it was reported that the dietary supplement of -E-mail: mivan@putra.upm.edu.my bentonite reduced the accumulation of dietary Cu in the liver of sheep by 29% (Ivan et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

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Effects of dietary molybdenum, sulfur and zinc on the excretion and tissue accumulation of trace elements in sheep fed palm kernel cake-based diets

Al-Kirshi

Alimon

Ivan

2011

Animal

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Twelve male 8-month-old lambs were used in a 6-month feeding experiment to determine the effects of dietary Mo, Mo 1 S and Zn supplements on the body retention and tissue accumulation of dietary Cu, Zn and Fe. The lambs were divided into four groups of three lambs each and each group was fed ad libitum one of four diets. A control diet was based on palm kernel cake (PKC) and grass hay. Three additional diets were the control supplemented with either Mo or Mo 1 S or Zn. At 3 months of the experiment, feces and urine were collected and sampled for 6 days. At the end of the experiment (6 months), blood was sampled and then the sheep were slaughtered. The liver and kidney were removed and sampled for chemical analysis. In comparison with the control, each dietary supplement decreased (P , 0.05) the Cu concentration in the liver, but only the Mo 1 S supplement decreased it to a safe range of below 350 mg/g dry matter. This was accompanied by the body retention of dietary Cu of 24.6%, 6.7%, 2.5% and 6.5% for the control, Mo, Mo 1 S and Zn treatments, respectively. The blood plasma concentration of Cu was decreased (P , 0.05) by the Zn supplement, but was not affected by other supplements (P . 0.05). It was concluded that from the supplements tested, only Mo 1 S appeared to be effective in reducing the retention and liver accumulation of the dietary Cu to prevent chronic Cu toxicity in sheep fed PKC-based diets.

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Protective effect of zinc supplementation against copper toxicosis in sheep

Cited by 108 publications

References 24 publications

The Effects of Hyperbaric Oxygen Treatment on Oxidant and Antioxidants Levels during Liver Regeneration in Rats

The Effects of Hyperbaric Oxygen Treatment on Oxidant and Antioxidants Levels during Liver Regeneration in Rats

Copper and zinc metabolism in health and disease: speciation and interactions

Effects of dietary molybdenum, sulfur and zinc on the excretion and tissue accumulation of trace elements in sheep fed palm kernel cake-based diets

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