Protective effect ofPhyllanthus fraternus against carbon tetrachloride-induced mitochondrial dysfunction

Padma, P. Naga; Setty, Oruganti H.

doi:10.1016/s0024-3205(99)00195-2

Cited by 33 publications

(11 citation statements)

References 15 publications

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“…However, the studies conducted at Central Drug Research Institute, Lucknow inferred that 50% ethanolic extract of Phyllanthus fraternus and Phyllanthus maderaspatensis also possess significant hepatoprotective activity (40 and 80%, respectively) in CCl 4 -induced hepatotoxicity. This finding was also supported by other workers (Padma and Setty, 1999;Asha et al, 2004). Thus, it may be concluded that phyllanthin and hypophyllanthin may not be solely responsible for hepatoprotective action.…”

Section: Discussionsupporting

confidence: 86%

“…Current research has focused on Phyllanthus amarus as potential plant for the treatment of hepatitis B by suppressing the growth and replication of the virus (Venkateswaran et al, 1987;Thyagarajan et al, 1988;Yeh et al, 1993;Jayaram and Thyagarajan, 1996;Lee et al, 1996). Phyllanthin and hypophyllanthin present in Phyllanthus amarus are also reported as hepatoprotective agents and protect hepatocytes against carbon tetrachloride (CCl 4 ) and galactosamine induced cytotoxicity in rats (Syamsundar et al, 1985 to show hepatoprotective activity against carbon tetrachlorideinduced mitochondrial dysfunction (Padma and Setty, 1999) and acetaminophen-induced hepatotoxicity (Asha et al, 2004), respectively.…”

Section: Introductionmentioning

confidence: 99%

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Comparative pharmacognostic studies of three Phyllanthus species

Khatoon

Rai

Rawat

et al. 2006

Journal of Ethnopharmacology

104

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Comparative pharmacognostic studies of three Phyllanthus species

Khatoon

Rai

Rawat

et al. 2006

Journal of Ethnopharmacology

104

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“…Indeed, several natural products were reported with their protective efficacy against CCl 4 -induced hepatotoxicity [17]. The medicinal herbs Artemisia campestris [18] and Phyllanthus fraternus [19] have been found to scavenge free radicals and therein to exert a hepatoprotective effect against CCl 4 -induced liver injury. Free radicals, from both endogenous and exogenous sources, are implicated in the etiology of several degenerative diseases such as coronary artery disease, stroke, rheumatoid arthritis, diabetes and cancer [20].…”

Section: Discussionmentioning

confidence: 99%

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

et al. 2010

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BackgroundCarbon tetra chloride (CCl4), an industrial solvent, is a hepatotoxic agent and it is the well established animal model for free radical-induced liver injury. The present investigation was carried out to establish the protective effect of natansnin, a novel dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver.ResultsCCl4 significantly increased the levels of lipid peroxides, oxidized glutathione and decreased the levels of reduced glutathione, SOD and CAT. CCl4 induce marked histopathological changes and increase in the levels of apoptotic proteins. CCl4 treatment significantly increased the levels of apoptotic proteins such as caspases-3, PARP, Bax, Bid and cytochrome C and also increased the levels of inflammatory mediators iNos and Cox-2. Natansnin treatment significantly decreased the levels of CCl4 induced apoptotic proteins and inflammatory mediators. Further natansinin treatment significantly inhibited the CCl4 induced apoptosis which was evident form the reduced TUNEL positive cells.ConclusionsIn conclusion, our study demonstrated the protective effect of natansnin against CCl4 induced oxidative stress and cellular degeneration in rat liver tissue. This protective effect of natansnin can be correlated to its direct antioxidant effect.

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“…Carbon tetrachloride toxicity is potentiated by the induction of CYP2E1 by ethanol 67–69 , and CYP2E1-null mice are protected from carbon tetrachloride hepatotoxicity 63 . Carbon tetrachloride toxicity includes mitochondrial dysfunction, with exposures resulting in impaired liver mitochondrial respiration, reduced mitochondrial DNA integrity, and impairment of individual mitochondrial respiratory complex activities 70–72 .…”

Section: Exogenous Substrates Of Cyp2e1 That Damage Mitochondriamentioning

confidence: 99%

Toxicological implications of mitochondrial localization of CYP2E1

2017

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Cytochrome P450 2E1 (CYP2E1) metabolizes an extensive array of pollutants, drugs, and other small molecules, often resulting in bioactivation to reactive metabolites. Therefore, it is unsurprising that it has been the subject of decades of research publications and reviews. However, while CYP2E1 has historically been studied in the endoplasmic reticulum (erCYP2E1), active CYP2E1 is also present in mitochondria (mtCYP2E1). Relatively few studies have specifically focused on mtCYP2E1, but there is growing interest in this form of the enzyme as a driver in toxicological mechanisms given its activity and location. Many previous studies have linked total CYP2E1 to conditions that involve mitochondrial dysfunction (fasting, diabetes, non-alcoholic steatohepatitis, and obesity). Furthermore, a large number of reactive metabolites that are formed by CYP2E1 through metabolism of drugs and pollutants have been demonstrated to cause mitochondrial dysfunction. Finally, there appears to be significant inter-individual variability in targeting to the mitochondria, which could constitute a source of variability in individual response to exposures. This review discusses those outcomes, the biochemical properties and toxicological consequences of mtCYP2E1, and highlights important knowledge gaps and future directions. Overall, we feel that this exciting area of research is rich with new and important questions about the relationship between mtCYP2E1, mitochondrial dysfunction, and pathology.

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Protective effect ofPhyllanthus fraternus against carbon tetrachloride-induced mitochondrial dysfunction

Cited by 33 publications

References 15 publications

Comparative pharmacognostic studies of three Phyllanthus species

Comparative pharmacognostic studies of three Phyllanthus species

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

Toxicological implications of mitochondrial localization of CYP2E1

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