Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats

Dhiyaaldeen, Summaya M.; Amin, Zahra A.; Darvish, Pouya; Mustafa, Iman Fahmi; Jamil, Mazen.M.; Rouhollahi, Elham; Abdulla, Mahmood Ameen

doi:10.1186/s12917-014-0303-7

Cited by 34 publications

(29 citation statements)

References 27 publications

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“…Thus, these results demonstrate that C. barometz hair extract is a protective agent and prevents alcohol-induced damage to the rat stomach, which is associated with decreased expression of the Bax protein. Similarly, many amendments have been described by many investigators [18, 48]. Animals pre-fed with C. barometz hair extract displayed decreased expression of the Bax protein.…”

Section: Discussionmentioning

confidence: 68%

RETRACTED ARTICLE: The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in Sprague-Dawley rats

et al. 2017

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Background Cibotium barometz is a medical herb used traditionally in the Malaysian peninsula for several ailments, including gastric ulcer. The aim of this study was assessment the anti-ulcer effects of C. barometz hair on ethanol-induced stomach hemorrhagic abrasions in animals. Seven groups of Sprague Dawley (SD) rats were administered 10% Tween 20 in the normal control and ulcer control groups, and omeprazole 20 mg/kg and 62.5, 125, 250, and 500 mg/kg of C. barometz hair extract in the experimental groups. After 60 min, the normal control group of rats was orally administered 10% Tween 20, while absolute ethanol was orally administered to the groups of ulcer control, omeprazole and experimental groups. Stomachs of the rats were examined macroscopically and histologically. Homogenates of stomachs were used to evaluate endogenous antioxidant enzyme activities.ResultsRats pre-fed with plant extract presented a significant decrease in the sore area, increased pH of gastric contents and preserved stomach wall mucus compared to the ulcer group. Histologically, rats pre-fed with C. barometz hair extract showed mild to moderate disruptions of the surface epithelium while animals pre-fed with absolute ethanol showed severe disruptions of the stomach epithelium with edema and leucocyte penetration of the submucosal layer. A Periodic acid Schiff (PAS) staining revealed that each rat pre-treated with the plant extract displayed an intense uptake of stomach epithelial glycoprotein magenta color compared to the ulcer control group. Immunohistochemical analysis revealed that rats pre-fed with the plant extract showed an up-regulation of the heat shock protein 70 (HSP70) and down-regulation of Bax proteins compared to ulcer control rats. Homogenates of the stomach tissue demonstrated significant increases in the endogenous antioxidant enzymatic activity and decreased lipid peroxidation (MDA) in rats pre-treated with C. barometz hair extract compared with the ulcer control rats. In acute toxicity, the liver and kidney revealed no hepatotoxic or nephrotoxic effects histologically.ConclusionsThe gastric cytoprotective action of C. barometz hair extract might be attributed to antioxidants, an increase in gastric pH, stomach mucus preservation, increased endogenous antioxidant enzymes, decreased lipid peroxidation, up-regulation of HSP70 and down-regulation of Bax proteins.

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Section: Discussionmentioning

confidence: 68%

RETRACTED ARTICLE: The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in Sprague-Dawley rats

et al. 2017

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“…Edema and hemorrhagic abrasions in the mucosal layer in the ulcer control group is known as an indicator of ethanol damage. These effects agree with other results reported by several researchers 32,56,58–62. In the PAS staining assessment, this study demonstrated that C. barometz extract heightened the content of glycoprotein in the gastric mucosa (the magenta color).…”

Section: Discussionsupporting

confidence: 93%

The antiulcer effect of <em>Cibotium barometz</em> leaves in rats with experimentally induced acute gastric ulcer

Al-Wajeeh¹,

Hajrezaie²,

Al-Henhena³

et al. 2017

DDDT

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Cibotium barometz is a pharmaceutical plant customarily used in traditional medicine in Malaysia for the treatment of different diseases, such as gastric ulcer. The gastroprotective effect of C. barometz leaves against ethanol-induced gastric hemorrhagic abrasions in Sprague Dawley rats has been evaluated in terms of medicinal properties. Seven groups of rats (normal control and ulcerated control groups, omeprazole 20 mg/kg, 62.5, 125, 250, and 500 mg/kg of C. barometz correspondingly) were used in antiulcer experiment and pretreated with 10% Tween 20. After 1 hour, the normal group was orally administered 10% Tween 20, whereas absolute alcohol was fed orally to ulcerated control, omeprazole, and experimental groups. Gastric’s homogenate were assessed for endogenous enzymes activities. Stomachs were examined macroscopically and histologically. Grossly, the data demonstrated a significant decrease in the ulcer area of rats pretreated with plant extract in a dose-dependent manner with respect to the ulcerated group. Homogenates of the gastric tissue exhibited significantly increased endogenous enzymes activities in rats pretreated with C. barometz extract associated with the ulcerated control group. Histology of rats pretreated with C. barometz extract group using hematoxylin and eosin staining exhibited a moderate-to-mild disruption of the surface epithelium with reduction in submucosal edema and leucocyte infiltration in a dose-dependent manner. In addition, it showed heat shock protein70 protein up-expression and BCL2-associated X protein downexpression. These outcomes might be attributed to the gastroprotective and antioxidative effects of the plant.

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“…Gastric ulcer is a disease that affects a large number of people in the world.It is corroded in the duodenum or the lining of the stomach happening on a site where the mucosal epithelium is presented to pepsin and acid and it is instigated by numerous factors, including smoking, stress, alcohol consumption, nutritional deficiencies and regular ingestion of non-steroidal anti-inflammatory drugs (NSAIDs) (Belaiche et al, 2002).Gastric ulcers related to the usage of NSAIDs stay one of the major clinical issues everywhere throughout the world (Dhiyaaldeen et al,2014). Tulassay and Herszényi (2010) detailed that the pathophysiology of gastric ulcers depends on the imbalance between defensive factors and the aggressiveness of the gastric mucosa.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Effect of Borago Extracts against Indomethacin-Induced Gastric Ulcer in Rats

Gazwi

Mahmoud

2018

Journal of Food and Dairy Sciences

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Gastric ulcer stays one of the perilous sicknesses in the world. In spite of the fact that there are numerous medications utilized for the treatment of gastric ulcer, the vast majority of these deliver a few adverse impacts. The aim of this investigation was to assess the antiulcer effects of Borago (Borago officinalis L) leaves extract (BL), flowers extract (BF) and the mixture of leaves and flowers extracts (Mix) against gastric ulcer induced by indomethacin in rats and compared with ranitidine as a reference drug. Gastric ulceration was stimulated by indomethacin at one dose (30 mg/kg b.w. Intraperitoneal (i.p)). BL and BF were administered orally at two doses of 100 and 200 mg/kg b.w, Mix was given orally at a dose of 200 mg/kg b.w. and ranitidine at a dose of 20 mg/kg b.w. for three weeks before the injection of indomethacin. The results appeared that indomethacin significantly decreased pH value, mucin content, catalase activity (CAT) and nitric oxide (NO), while, increased ulcer index, total acidity, free acidity and malondialdehyde (MDA) comparing with control group.While, pretreatment with Borago extracts provided a significant decrease in ulcer index, total acidity,free acidity, MDA, and associated with a significant rise in pH value, mucin content, CAT and NO compared to indomethacin group. The protection provided by the extracts of Borago is similar to ranitidine. Histological studies of stomach mucosa affirmed these outcomes. Borago has protective against indomethacin which caused gastric ulcer because of it contains antioxidant properties. The results of the present suggest that Borago can be utilized against gastric ulcer impacts as well as to decrease antagonist drugs adverse effects.

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Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats

Cited by 34 publications

References 27 publications

RETRACTED ARTICLE: The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in Sprague-Dawley rats

RETRACTED ARTICLE: The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in Sprague-Dawley rats

The antiulcer effect of <em>Cibotium barometz</em> leaves in rats with experimentally induced acute gastric ulcer

Gastroprotective Effect of Borago Extracts against Indomethacin-Induced Gastric Ulcer in Rats

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