Protective effects of 1‐α‐hydroxyvitamin D3 on residual β‐cell function in patients with adult‐onset latent autoimmune diabetes (LADA)

Li, Xia; Ling, Lan; Yan, Xiang; Huang, Gan; Lin, Jian; Lei, Minxiang; Wang, Xiangbing; Zhou, Zhiguang

doi:10.1002/dmrr.977

Cited by 107 publications

(73 citation statements)

References 28 publications

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“…In addition, the onset that occurs at a young age also affects the levels of C-peptide [39]. This result is different from the studies conducted in China where there was a significant positive correlation between vitamin D levels and Cpeptide levels [33]. Similarly, the results of a study conducted in Boston showed a significant positive correlation between vitamin D and C-peptide levels [27].…”

Section: Subject Characteristicscontrasting

confidence: 59%

“…Seventy percent of patients treated with 1-alpha(OH)D 3 of their FCP concentrations persisted or increased after 1 year of treatment, while only 22% of the patients treated with insulin alone had stable FCP levels. Further analysis with different time periods of diabetes showed that better beta-cell beta functions were maintained (reflected significantly higher FCP and PCP levels) in the group receiving 1-alpha(OH)D 3 therapy plus Insulin [33]. Research in Iran, where the intervention group received alfacalcidol 0.25 µg twice daily, while the control group received placebo.…”

Section: Subject Characteristicsmentioning

confidence: 99%

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Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D 3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D 3 , IL-2, and C-peptide in people with T1DM who received vitamin D 3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D 3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D 3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D 3 and IL-2 (p = 0.71; r = -0.12), 25(OH)D 3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D 3 supplementation in patients with T1DM can increase levels 25(OH)D 3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.

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Section: Subject Characteristicscontrasting

confidence: 59%

Section: Subject Characteristicsmentioning

confidence: 99%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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“…The outcome of that study shows that such a trial is feasible. A Chinese intervention trial in patients with late-onset autoimmune diabetes reported that the daily use of 0.5 lg alphacalcidol (1a-hydroxyvitamin D) for 12 mo resulted in better preserved b cell function (28).…”

Section: Vitamin D and Vitamin Ementioning

confidence: 99%

Infant feeding and the risk of type 1 diabetes

Knip

Virtanen²,

Åkerblom³

2010

The American Journal of Clinical Nutrition

134

100

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Type 1 diabetes is generally considered to be a chronic, immunemediated disease with a subclinical prodrome during which b cell autoimmunity becomes overt disease at a variable rate in genetically susceptible individuals. Accumulated evidence supports a critical role of environmental factors in its development. Prospective birth cohort studies show that the first signs of b cell autoimmunity may be initiated during the first year of life. This implies that risk factors for b cell autoimmunity and type 1 diabetes must be operative in infancy. Early nutrition provides essential exogenous exposures in that period. This article discusses the role of factors related to infant nutrition in the development of b cell autoimmunity and type 1 diabetes and the potential mechanistic pathways involved. So far, no specific dietary factor has been shown to be an unequivocal risk factor for b cell autoimmunity or type 1 diabetes, and there are a number of contradictory observations with regard to the effect of various foods. This may reflect geographic and cultural differences in infant-feeding practices. Most studies suggest that the early introduction of complex foreign proteins may be a risk factor for b cell autoimmunity, and a pilot intervention trial has implied that weaning to a highly hydrolyzed formula may decrease the risk of b cell autoimmunity. Lack of vitamin D supplementation and accelerated growth might increase the risk of type 1 diabetes. Additional work, which includes the application of modern approaches such as metabolomics and epigenomics, is needed to discern the contribution of dietary factors in infancy to the diabetic disease process.Am J Clin Nutr 2010;91(suppl):1506S-13S.

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“…Debe mencionarse que un estudio aislado muestra que la adición de vitamina D (1 α hidroxi D3) podría colaborar a preservar la reserva pan creática en pacientes con LADA, en asociación a la insulinoterapia 30 .…”

Section: Insulinaunclassified

Diabetes autoinmune (latente) del adulto

2012

Rev. méd. Chile

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Protective effects of 1‐α‐hydroxyvitamin D3 on residual β‐cell function in patients with adult‐onset latent autoimmune diabetes (LADA)

Abstract: Our data suggest that 1-alpha(OH)D3 plus insulin therapy can preserve pancreatic beta-cell function in patients with LADA.

Cited by 107 publications

References 28 publications

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Infant feeding and the risk of type 1 diabetes

Diabetes autoinmune (latente) del adulto

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