Protective effects of 1α,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture

Ibi, Masakazu; Sawada, Hideyuki; Nakanishi, Miki; Kume, Toshiaki; Katsuki, Hiroshi; Kaneko, Shuji; Shimohama, Shun; Akaike, Akinori

doi:10.1016/s0028-3908(01)00009-0

Cited by 219 publications

(149 citation statements)

References 28 publications

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“…Parallel, the anti-inflammatory properties of vitamin D may be involved as there is evidence for a pivotal role of vitamin D in the immune system [29,30] by modulating effect on the immune cells that produce vitamin D and express the VDR. Finally, the antioxidant properties of vitamin D against oxidative stress of reactive oxygen and nitrogen species in the central nervous system [31] should also be mentioned.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

et al. 2015

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a b s t r a c tObjectives: Vitamin D is involved in visual health and function. Our objective was to determine whether age-related vitamin D insufficiency was associated with the presence and the severity of primary open angle glaucoma (POAG) in a case-control study of older adults. Study design: Case-control study.Main outcome measures. One hundred fifty cases diagnosed with moderate-to-severe POAG (mean, 75.1 ± 8.5 years; 42.0% female) and 164 healthy controls (mean, 73.0 ± 7.9 years; 59.8% female) were included. POAG diagnosis was based on classical diagnostic criteria of optic nerve cupping and/or RNFL thinning, measured with optical coherence tomography. Severe POAG was defined as Humphrey visual field mean deviation (MD) worse than −12 dB. Vitamin D insufficiency was defined as serum 25OHD ≤ 75 nmol/L. Age, gender, mean arterial pressure, vitamin D supplementation, visual acuity, and intraocular pressure were used as potential confounders. Results: POAG cases had lower mean serum 25OHD concentration than controls (42.9 ± 25.7 nmol/L versus 49.4 ± 29.5 nmol/L, P = 0.039) and a greater prevalence of vitamin D insufficiency (90.7% versus 82.3%, P = 0.032). Increased mean serum 25OHD concentrations were associated with lower POAG frequency, even after adjustment for potential confounders (OR = 0.89 per 10 nmol/L of 25OHD, P = 0.045). Similarly, vitamin D insufficiency was associated with POAG (OR = 2.09, P = 0.034). Among POAG cases, no 25OHD difference was observed between moderate and severe POAG cases (respectively, 39.2 ± 23.3 nmol/L versus 45.1 ± 26.7 nmol/L, P = 0.188); and no between-group difference regarding the prevalence of vitamin D insufficiency (88.9% versus 94.0%, P = 0.313). Conclusions: Decreased serum 25OHD concentration was associated with POAG. There was no 25OHD difference between moderate and severe POAG.

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Section: Discussionmentioning

confidence: 99%

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

et al. 2015

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“…25(OH)D is necessary for production of activated vitamin D (1,25[OH 2 ]D), which, in turn, has antioxidant, neuroprotective and vasculoprotective properties (8)(9)(10). 25(OH)D deficiency is present in a considerable proportion of patients undergoing hemodialysis (11,12), and at least in the general population it is associated with vascular disease (6,7), cognitive impairment, and an increased prevalence of white-matter hyper intensities and large-vessel infarcts on brain magnetic resonance imaging (7).…”

Section: Introductionmentioning

confidence: 99%

Low 25-Hydroxyvitamin D Levels and Cognitive Impairment in Hemodialysis Patients

Shaffi¹,

Tighiouart

Scott

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives 25-hydroxyvitamin D (25[OH]D) deficiency and cognitive impairment are both prevalent in hemodialysis patients in the United States. This study tested the hypothesis that 25(OH)D deficiency may be associated with cognitive impairment because of its vasculoprotective, neuroprotective, and immunemodulatory properties.Design, setting, participants, & measurements This cross-sectional analysis involved 255 patients enrolled in the Dialysis and Cognition Study between 2004 and 2012. In linear regression models, 25(OH)D was the exposure variable; it was used first as a continuous variable and then stratified as deficient (,12 ng/ml), insufficient (12 to ,20 ng/ml), and sufficient ($20 ng/ml). Principal component analysis was used to obtain the memory and the executive function domains from the individual neurocognitive tests. Scores on individual tests as well as on the memory and executive function domains were the outcome variables. Multivariable models were adjusted for age, sex, race, education, and other potential confounding variables.Results Mean serum 25(OH)D 6 SD was 17.267.4 ng/ml, with 14%, 55%, and 31% of patients in the deficient, insufficient, and sufficient groups, respectively. Patients in the deficient group were more likely to be women, African American, and diabetic and to have longer dialysis vintage. Conclusions 25(OH)D deficiency in hemodialysis patients is associated with worse cognitive function, particularly in domains that assess executive function.

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“…Yapılan birçok deneysel nörodejenerasyon modelinde vitamin D 3 'ün ayrıca nöroprotektif olduğu da gösterilmiştir (53)(54)(55). Çalışmalarda vitamin D 3 'ün nitrit oluşumunu azalttığı ve gama glutamil transpeptitaz ekspresyonunu arttırarak oksidatif stresi azalttığı gösterilmiştir (56). Ayrıca in vivo çalışmalarda orta serebral arter tıkanıklığı sonrası kortikal enfarktı azalttığı gözlenmiştir (57).…”

Section: Discussionunclassified

Therapeutic effects of vitamin D3 on motor functions following experimental spinal cord injury

Çelik¹,

Mutevelizade²,

Harman³

et al. 2015

tnd

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Amaç: Akut spinal kord yaralanması (SKY) sonrası nörolojik hasar, primer mekanik yaralanma ile olduğu kadar sekonder olarak doku hasarına yol açan hücre ölümü aktivasyon kaskatlarından da kaynaklanmaktadır. Bu çalışmada vitamin D 3 'ün sıçanlarda oluşturulan deneysel SKY sonrasında motor fonksiyonlar üzerindeki iyileştirici etkinliği araştırıldı. Gereç ve Yöntem:Bu çalışma Sağlık Bakanlığı Haydarpaşa Numune Eğitim ve Araştırma Hastanesi'nde yapıldı. Çalışmada 3 grupta, 7'şer adet olmak üzere toplam 21 adet Spraque-Dawley cinsi sıçan kullanıldı. İlk gruba sadece laminektomi yapıldı (kontrol grubu). İkinci gruba laminektomi yapılıp omurilik yaralanması oluşturuldu (travma grubu). Üçüncü gruba laminektomi yapılıp omurilik yaralanması oluşturuldu ve 1., 3., 5., 7. günlerde intraperitoneal olarak 1 mcg/kg/gün dozunda vitamin D 3 enjeksiyonu yapıldı (vitamin D 3 grup). Deneklerin fonksiyonel iyileşmeleri cerrahi işlem sonrası 1., 7., 14. ve 21. günlerde eğik düzlem testi, Drummond ve Moore motor fonksiyon skoru ile değerlendirildi. Kontrol, travma ve vitamin D 3 uygulanan gruplardaki doku parçaları hematoksileneozin (HE) boyası ile boyanıp ışık mikroskobunda incelendi. Bulgular: Vitamin D 3 grubunda eğik düzlem testi sonuçları ve motor fonksiyon skorları travma grubu ile karşılaştırıldığında 1., 2. ve 3. haftalarda anlamlı olarak daha yüksek bulundu. Objective: Spinal cord injuries are frequently encountered and is a major health problem due to the severe disability they cause. The neurological damage of acute spinal cord trauma triggers primary mechanisms of injury and cell death activation cascades leading to tissue damage. The aim of this study was to investigate the therapeutic effects of vitamin D 3 in a rat model of spinal cord injury. Materials and Methods:The study was performed at Haydarpaşa Numune Training Hospital, İstanbul, Turkey. Twenty-one Spraque-Dawley rats were randomly assigned to the following study groups: the control group, undergoing laminectomy procedure; trauma group, undergoing spinal cord injury after laminectomy; and trauma plus vitamin D 3 group, undergoing spinal cord injury after laminectomy and subsequent administration of vitamin D 3 on days 1, 3, 5, 7 intraperitoneally with a dosage of 1 mcg/kg/day. The functional outcome was evaluated by using inclined plane test and Drummond and Moore motor function

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Protective effects of 1α,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture

Cited by 219 publications

References 28 publications

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

Low 25-Hydroxyvitamin D Levels and Cognitive Impairment in Hemodialysis Patients

Therapeutic effects of vitamin D3 on motor functions following experimental spinal cord injury

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