2017
DOI: 10.1016/j.biopha.2017.10.125
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Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells

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Cited by 19 publications
(15 citation statements)
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“…Indeed, the lowering of total cholesterol, triglycerides, LDL-c levels and increase HDL-c levels induced by the formulation F (1:1) may be due to their richness in phenolic compounds such as phytosterols (found in avocado) in particular the beta-sitosterols which are known to induce a decrease in plasma lipoprotein and cholesterol levels by decreasing cholesterol solubility and absorption across the intestinal barrier [ 6 , 40 , 41 ]. Bioactive compounds of the formulation such as allicin can also increase the activation of AMPK to suppress cholesterol synthesis [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, the lowering of total cholesterol, triglycerides, LDL-c levels and increase HDL-c levels induced by the formulation F (1:1) may be due to their richness in phenolic compounds such as phytosterols (found in avocado) in particular the beta-sitosterols which are known to induce a decrease in plasma lipoprotein and cholesterol levels by decreasing cholesterol solubility and absorption across the intestinal barrier [ 6 , 40 , 41 ]. Bioactive compounds of the formulation such as allicin can also increase the activation of AMPK to suppress cholesterol synthesis [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…The liver is the main organ to maintain the balance of fat metabolism. The imbalance of anabolism, transport, and catabolism of TG in liver cells is the main factor of fat metabolism disorder and the formation of fatty liver [37,38]. DGAT2 is the main ratelimiting enzyme in the TG synthesis pathway and is highly expressed in both fat and liver [39].…”
Section: Discussionmentioning
confidence: 99%
“…In this context, the beneficial effects of allicin involved the modulation of signaling pathways underlying the synthesis or degradation of lipids and carbohydrates. Thus, allicin increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), protein kinase A (PKA), and the AMP response element-binding protein (CREB) in a cell culture of hepatic lipotoxicity (HepG2) [ 46 ]. In contrast, allicin decreased the expression of the sterol regulatory element-binding protein 1 (SREBP-1) and the protein SREBP-2.…”
Section: Effects Of Allicin On Cardiovascular Risk Factorsmentioning
confidence: 99%