Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae against radiation‐induced testicular injury in mice

Abstract

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Fermented Protaetia brevitarsis Larvae Improves Neurotoxicity in Chronic Ethanol-Induced-Dementia Mice via Suppressing AKT and NF-κB Signaling Pathway

“…Previous studies have reported on the in vitro antioxidant activity and ROS inhibition effects of P. brevitarsis larvae in AML12 cells [ 12 , 28 ]. In addition, treatment with P. brevitarsis larvae resulted in reduced levels of ROS in mice with radiation-induced testicular injury [ 29 ]. According to a study reported by Lee et al, treatment with P. brevitarsis water extract resulted in improved cognitive function via the regulation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated oxidative stress in the hippocampus of TMT-treated mice [ 13 ].…”

“…Treatment with P. brevitarsis protein extract has been reported to decrease the BAX/BCL-2 ratio, thereby exerting a protective effect against cytotoxicity in H 2 O 2 -induced C2C12 cells [ 11 ]. In addition, the results of pretreatment with P. brevitarsis larvae showed a reduction in the number of apoptotic nuclei in radiation-induced rat testicular germ cells [ 29 ]. In agreement with findings reported in previous studies, in this study, FPB exhibited anti-apoptotic activity through a decrease in the BAX/BCL-2 ratio and activation of the AKT/GSK-3β pathway in ethanol-administered mice ( Figure 6 ).…”

Protaetia brevitarsis Extract Attenuates RANKL-Induced Osteoclastogenesis by Inhibiting the JNK/NF-κB/PLCγ2 Signaling Pathway

“…Many insect-derived bioactive substances are known to be used as antioxidants, anticoagulants, indigestion, inflammation, and hypertension [ 15 , 16 , 17 , 18 ]. Among them, bioactive substances derived from PB, an edible insect, have been used as a medicinal and functional food in many Asian countries due to their antioxidant, antidiabetic, anticancer, hepatoprotective, and testicular protective effects [ 20 , 21 , 22 , 23 ]. As a result of the component analysis of PB larvae in previous studies, oleic acid and volatile compounds were identified, and oleic acid was the most predominant fatty acid [ 19 , 20 ].…”

“…According to a recent report, oral administration of the PB larval extract to radiation-induced testicular injury male mice demonstrated testicular protective effects through reduction of germ cell apoptosis, improvement of sperm cell morphology and motility, and preservation of sperm count. In addition, it suppressed reactive oxygen species generation and exhibited antioxidative effects [ 23 ]. A recent study reported that PB extracts regulated bone remodeling in mice with OVX-induced osteoporosis and decreased RANKL-stimulated osteoclastogenesis by inhibiting p38 MAPK activation and NF-κB phosphorylation [ 24 ].…”

Possible association of G6PC2 and MUC6 induced by low‑dose‑rate irradiation in mouse intestine with inflammatory bowel disease

“…Normal cells are also damaged by high-dose radiation resulting from accidental radiation leaks, with detrimental effects on the quality of life in survivors ( 2 ). Several research teams are attempting to identify compounds that can protect radiosensitive organs, such as the testis ( 3 ), intestines ( 4 ) and hippocampus ( 5 ). However, there is controversy about how low-dose radiation exposure (≤0.2 Gy) ( 6 ), such as that from imaging diagnosis (X-ray or computed tomography scan), affects the health of patients ( 7 , 8 ).…”