Protective effects of astaxanthin on lipopolysaccharide-induced inflammation in bovine endometrial epithelial cells†

Wan, Fachun; Zhang, Chen; Jin, Qinian; Chen, Wei; Zhao, Hang; Zhang, Xiang-Lun; Wang, You; Liu, Xiaomu; Liu, Guifen; Liu, Yifan; Tan, Xiaodong

doi:10.1093/biolre/ioz187

Cited by 26 publications

(13 citation statements)

References 39 publications

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“…For in vitro assays, NIH 3T3 cells were cultured in DMEM containing 10% FBS and 1% AA. To evaluate cytotoxicity of Lec NS and ASTA@Lec NS, cells were seeded into a 96-well plate at a density of 10,000 cells per well and incubated in a humidified atmosphere of 5% CO 2 at 37°C 34,35. After 12 h incubation, different concentrations of the nano-liposols were added to the cells and…”

mentioning

confidence: 99%

<p>Potential Antioxidant and Wound Healing Effect of Nano-Liposol with High Loading Amount of Astaxanthin</p>

Oh¹,

Lee²,

Sung³

et al. 2020

IJN

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Background: Astaxanthin (ASTA), a carotenoid, is a strong antioxidant. However, its application in functional foods, pharmaceuticals, and cosmetics remains limited due to its low aqueous solubility and stability. Several different encapsulating materials have been used to improve the stability and bioavailability of ASTA; however, the currently investigated nano-carriers for ASTA require additional improvements with regard to their loading capacity and stability. Methods: In this study, we developed lecithin nano-liposol (Lec NS) as a novel carrier of ASTA using a simple emulsion evaporation method. The physicochemical characteristics including hydrodynamic diameter, polydispersity index, surface charge and morphology were analyzed by DLS and TEM. The antioxidant activity of the ASTA-loaded Lec NS (ASTA@Lec NS) was evaluated using a DPPH radical scavenging assay and in vitro antioxidant assay. The study of in vitro wound healing efficacy was carried out to observe the beneficial effect of antioxidant activity of ASTA@Lec NS on cell migration. Results: ASTA@Lec NS showed improved stability and efficacy owing to improved aqueous solubility of ASTA inside Lec NS. Both in situ and in vitro antioxidant activities of ASTA@Lec NS were higher than that of bare ASTA and Lec NS. It also exhibited strong wound healing efficacy by regulation of ROS level in in vitro cell model. Conclusion: This study revealed that the encapsulation of ASTA into Lec NS using a wet phase transfer enhanced its physiological stability and bioavailability for effective scavenging of reactive oxygen species.

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mentioning

confidence: 99%

<p>Potential Antioxidant and Wound Healing Effect of Nano-Liposol with High Loading Amount of Astaxanthin</p>

Oh¹,

Lee²,

Sung³

et al. 2020

IJN

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“…Furthermore, AST significantly increased the expression of claudin, a tight junction protein that may play an important role in maintaining the host endometrial defense barrier against pathogenic infection. Collectively, these results suggest that AST is a promising agent for endometritis ( 19 ).…”

Section: Innate Immunity Of the Genital Tract (The Mucosal Immune Sys...mentioning

confidence: 86%

The Interplay Between Cervicovaginal Microbial Dysbiosis and Cervicovaginal Immunity

Wang

Zhu

et al. 2022

Front. Immunol.

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The cervicovaginal microbiota plays a key role in the health and reproductive outcomes of women. In reality epidemiological studies have demonstrated that there is an association between the structure of cervicovaginal microbiota and reproductive health, although key mechanistic questions regarding these effects remain unanswered and understanding the interplay between the immune system and the structure of the cervicovaginal microbiota. Here, we review existing literature relating to the potential mechanisms underlying the interaction between vaginal microbes and the immune system; we also describe the composition and function of the microbiome and explain the mechanisms underlying the interactions between these microbial communities and various aspects of the immune system. Finally, we also discuss the diseases that are caused by disorders of the reproductive tract and how the immune system is involved. Finally, based on the data presented in this review, the future perspectives in research directions and therapeutic opportunities are explored.

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“…Likewise, the beneficial role of this carotenoid in dry eye treatment was confirmed in human corneal epithelial cells via reduction in TNF-α and IL-1β levels [217]. Finally, the anti-inflammatory and antioxidant effects of this carotenoid have been demonstrated in other in vitro models, including bovine endometritis [218], gastric inflammation by H. pylori [219], and osteoporosis [220].…”

Section: Astaxanthin 441 In Vitro Studiesmentioning

confidence: 87%

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

et al. 2021

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Acute inflammation is a key component of the immune system’s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as α- and β-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, α- and β-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.

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Protective effects of astaxanthin on lipopolysaccharide-induced inflammation in bovine endometrial epithelial cells†

Cited by 26 publications

References 39 publications

<p>Potential Antioxidant and Wound Healing Effect of Nano-Liposol with High Loading Amount of Astaxanthin</p>

<p>Potential Antioxidant and Wound Healing Effect of Nano-Liposol with High Loading Amount of Astaxanthin</p>

The Interplay Between Cervicovaginal Microbial Dysbiosis and Cervicovaginal Immunity

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

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