Protective effects of bilobalide on Aβ25–35 induced learning and memory impairments in male rats

Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer’s disease by inhibition of glial activation, cholinesterase, and oxidative stress

“…Our model of AD in this study was according to earlier studies proving bilateral injection of aggregated Ab [25][26][27][28][29][30][31][32][33][34][35] into the CA1 area of the hippocampus leads to learning and memory deficits [26,34]. Our findings show that bilateral CA1 hippocampal microinjections of A b25-35 provoked striking loss in spatial memory performance as depicted in the escape latency and distance swum (Table 1).…”

“…However, the discrepancy for the last training day and the better performance compared with other groups during MWM test would be rooted in different factors. The first clear reason is the dose difference and administration route of A b25-35 [35,36]. Another possible explanation is that the learning step is well established in this group due to a possible recovery phenomenon.…”

“…Averaged distance swum in Morris water maze.Averaged distance swum (cm) to locate hidden platform in Morris water maze (test days 1-5) as means AE SEM; Effect of bilateral CA1 microinjections of saline (Sham), Ab[25][26][27][28][29][30][31][32][33][34][35] (Ab), and Ab 25-35 + Pelargonidin (Pel) at a dose of 10 mg/kg (Pel) for 3 consecutive days (Ab + Pel). * P < 0.05.…”

Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice

“…Then the sections were examined by fluorescence microscopy (Olympus IX71) (Ex/Em: 352 nm/461 nm). The nuclear condensed cells under a high power field (400Â) in the frontal cortex, hippocampus CA1 and CA3 were counted in each section to indicate neuronal apoptosis (Yin et al, 2013).…”

Antagonists of Ionotropic Receptors for the Inhibitory Neurotransmitter GABA: Therapeutic Indications

“…Bilobalide has been shown to improve cognition in cognitive-and memory-impaired animals in a variety of animal models [62][63][64][65]. As a result to its nonconvulsant efects, bilobalide is a superior candidate for therapeutic use in memory impairment related to dementia and other neurological disorders compared with other GABA A receptor antagonists like picrotoxin which are pro-convulsive.…”