Protective Effects of Caffeic Acid Phenethyl Ester on Intestinal Ischemia-Reperfusion Injury

Yildiz, Yuksel; Serter, Mukadder; Ek, Rauf Onur; Ergin, Kemal; Çeçen, Serpil; Demir, Ece; Yenisey, Çiğdem

doi:10.1007/s10620-008-0405-9

Cited by 34 publications

(29 citation statements)

References 27 publications

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“…Some of them such as IL-12p40 and CD3 were targeted in human clinical trials [43,44]. Naturally occurring compounds proven to have antioxidant and anti-inflammatory effects such as resveratrol, caffeic acid phenethyl ester (CAPE) [45] and any other potential candidate drug or extract especially extracts of Atractylodes spp. and Poncirus trifoliate [46] can be used as adjuvant agent with new potential candidate molecules for IBD therapy.…”

Section: Current and Future Developmentsmentioning

confidence: 99%

Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats

Yıldız¹,

Yildiz²,

Ulutaş³

et al. 2015

EMI

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Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease in humans constituting a major health concern today whose prevalence has been increasing over the world. Production of reactive oxygen species (ROS) and disturbed capacity of antioxidant defense in IBD subjects have been reported. Antioxidants may play a significant role in IBD treatment. This study aimed at evaluating ameliorative effects of intraperitoneal resveratrol pretreatment on trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats. Thirty five Wistar-Albino female rats were divided equally into five groups. Inflammation was induced by the intrarectal administration of TNBS under anesthesia. Intraperitoneal administration of resveratrol (RSV) at a concentration of 10mg/kg/day for 5 days before the induction of colitis significantly reduced microscopy score and malondialdehyde (MDA) levels and increased glutathione peroxidase (GSH Px) activity compared to TNBS and vehicle groups. Also an insignificant increase in catalase (CAT) activity was observed in the RSV treated group compared to TNBS and vehicle groups. In this paper, the most recent patent on the identification and treatment of IBD was indicated. In conclusion, antioxidant RSV proved to have a beneficial effect on TNBS colitis in rats. In light of these advantageous results, the RSV can be considered as adjuvant agent in IBD treatments.

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Section: Current and Future Developmentsmentioning

confidence: 99%

Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats

Yıldız¹,

Yildiz²,

Ulutaş³

et al. 2015

EMI

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“…As a fi rst step, SOD detoxifi es the superoxide anion to hydrogen peroxide (35). The intestinal I/R injury was associated with dramatic increases in MDA level and MPO activity and decrease in SOD activity (31).…”

Section: Table 3 the Effects Of Exercise On Intestinal Tissue Injurymentioning

confidence: 99%

Effects of exercise preconditioning on intestinal ischemia- -reperfusion injury

Gökbel¹,

M²,

Okudan³

et al. 2014

BLL

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Abstract:Background: To investigate the effects of exercise preconditioning on oxidative injury in the intestinal tissue of rats. Methods: Sixty male Wistar rats were randomly divided into six groups as sham (n = 10), ischemia-reperfusion (n = 10), exercise (n = 10), exercise plus ischemia-reperfusion (n = 10), ischemic preconditioning (n = 10), and ischemic preconditioning plus ischemia-reperfusion groups (n = 10). Tissue levels of malondialdehyde and activities of myeloperoxidase and superoxide dismutase, and serum levels of tumor necrosis factor-alpha and interleukin-6 were measured. Intestinal tissue histopathology was also evaluated by light microscopy. Results: Tumor necrosis factor-alpha concentrations signifi cantly decreased in the exercise group compared to the sham group (p < 0.05). Myeloperoxidase activity signifi cantly increased and superoxide dismutase activity signifi cantly decreased in ischemia-reperfusion group compared to the sham group (p < 0.05). Superoxide dismutase activity in the ischemic preconditioning and ischemic preconditioning plus ischemia-reperfusion groups were signifi cantly higher compared to the ischemia-reperfusion and exercise groups (p < 0.05). Histopathologically, intestinal injury signifi cantly attenuated in the exercise plus ischemia-reperfusion group compared to the ischemia-reperfusion group. Conclusions:The results of the present study indicate that exercise training seems to have a protective role against intestinal ischemia-reperfusion injury (Tab. 3, Fig. 1, Ref. 35). Text in PDF www.elis.sk.

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“…It was demonstrated that administration of caffeic acid reduced oxidative stress by increasing antioxidant activities and decreasing oxidant status and lipid peroxidation in the intestine of rats in an experimental model of necrotizing enterocolitis (Tayman et al, 2011). Administration of caffeic acid has been also shown to completely block both the production of ROS from activated neutrophils and the XO system (Ma et al, 2006;Yildiz et al, 2009) and to protect intestinal tissues from ROS-mediated oxidative stress and reduce lipid peroxidation (Ek et al, 2008;Koltuksuz et al, 1999). Treatment of rats orally with caffeic acid resulted in a significant decrease in iron nitrilotriacetate-induced xanthine oxidase, lipid peroxidation, cglutamyl transpeptidase, and H 2 O 2 and there was a dose dependent and significant recovery of renal glutathione content and antioxidant enzymes (Rehman & Sultana, 2011).…”

Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 99%