Protective Effects of Calcitriol against Fructose-induced Hyperglycaemia and  Dyslipidaemia in male Albino Wistar rats

Lai, Ibrahim; Sadau, Yakubu; Maigari, Fatima Umar

doi:10.5455/ajrms.20180506085143

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“…We confirmed the protective role of this vitamin on these biochemical parameters in the experimental model of metabolic disorders in male Wistar rats. Our results are consistent with the findings of some previous studies in this area, which revealed a positive connection between vitamin D supplementation and the improvement of the lipid parameters, glucose and uric acid levels [15,22]. The significant difference in glucose levels of the groups supplemented with vitamin D, confirmed the protective role of the vitamin in the development of insulin resistance.…”

Section: Figuresupporting

confidence: 93%

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Vitamin D Effects on Lipid Profile and Uric Acid Levels in the Experimental Model of Metabolic Disorders in Fructose Fed Wistar Rats

PASHOVA-STOYANOVA

2019

FARMACIA

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A growing number of studies suggest that hyperuricemia and low vitamin D levels could contribute to the pathogenesis of metabolic disorders and the development of metabolic syndrome and vice versa -the development of metabolic disorders itself could lead to low vitamin D levels and high uric acid levels. The present study aims to investigate the role of vitamin D effects on uric acid levels and lipid profile in the experimental model of metabolic disorders in fructose fed male Wistar rats. In our study we confirmed the protective role of vitamin D and its effects in lowering the elevated uric acid levels. Vitamin D decreases glucose and uric acid concentrations and improves the cardiogenic lipid profile (cholesterol/HDL and LDL/HDL). RezumatUn număr tot mai mare de studii sugerează că hiperuricemia și nivelurile scăzute de vitamina D pot contribui la patogeneza tulburărilor metabolice și la dezvoltarea sindromului metabolic și vice-versa -dezvoltarea tulburărilor metabolice în sine ar putea conduce la niveluri scăzute de vitamina D și niveluri ridicate de acid uric. Studiul de față își propune investigarea rolului efectelor vitaminei D asupra nivelurilor de acid uric și asupra profilului lipidic într-un model experimental al tulburărilor metabolice la șobolani Wistar. În prezentul studiu a fost confirmat rolul protector al vitaminei D și efectele acesteia în asupra valorilor crescute de acid uric. Vitamina D scade concentrațiile de glucoză și acid uric și îmbunătățește profilul lipidelor cardiogene (colesterol/HDL și LDL/HDL).

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Section: Figuresupporting

confidence: 93%

“…The supplementation with vitamin D proved to have protective effect on the lipid profile of rats on fructose-rich diet. The effects vary and differ in enhancing the different lipid parameters [15,22]. The present study aims to investigate the effects of vitamin D on the lipid profile and uric acid levels in fructose fed Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Effects on Lipid Profile and Uric Acid Levels in the Experimental Model of Metabolic Disorders in Fructose Fed Wistar Rats

PASHOVA-STOYANOVA

2019

FARMACIA

View full text Add to dashboard Cite

show abstract

Protective Effects of Calcitriol against Fructose-induced Hyperglycaemia and Dyslipidaemia in male Albino Wistar rats

Cited by 1 publication

References 0 publications

Vitamin D Effects on Lipid Profile and Uric Acid Levels in the Experimental Model of Metabolic Disorders in Fructose Fed Wistar Rats

Vitamin D Effects on Lipid Profile and Uric Acid Levels in the Experimental Model of Metabolic Disorders in Fructose Fed Wistar Rats

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