Protective effects of chlorogenic acid in 3-nitropropionic acid induced toxicity and genotoxicity

Alarcón-Herrera, Norberto; Flores-Maya, Saúl; Bellido, Belén; García-Bores, Ana María; Mendoza, E. E.; Guillermo, Ávila-Acevedo; Hernández‐Echeagaray, Elizabeth

doi:10.1016/j.fct.2017.04.048

Cited by 23 publications

(12 citation statements)

References 39 publications

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“…In that sense, the resulted yields are lower than the reported by Herrera-Carrera et al [12] who made a salvilla infusion with 20.31 ± 0.61% of yield extraction, Avila-Acevedo and Romo-de-Vivar [15] and Avila-Acevedo et al [16] reported a 15.15% in a successive hexane – ethyl acetate – methanol salvilla extract. Our extracts have a higher yield extraction than the reported by Perez-Gutierrez and Vargas-Solis [31] in a successive hexane – chloroform - methanol salvilla extract, where they obtained 7.6%, and it is also higher than Alarcón-Herrera et al [32] who in a successive hexane – methanol extract obtained 10% of yield. In the extract yield all the independent variables in ethanol ( p < 0.05), time ( p < 0.05) and amplitude ( p < 0.05) influenced the response variable, as well as the interactions of the time and the solvent ( p < 0.05), time and the amplitude ( p < 0.05), and the time, solvent, and amplitude ( p < 0.05) (see supplementary information , Table S1 ).…”

Section: Resultscontrasting

confidence: 57%

Antioxidant and anti-inflammatory polyphenols in ultrasound-assisted extracts from salvilla (Buddleja scordioides Kunth)

Macías-Cortés

Gallegos‐Infante

Rocha‐Guzmán

et al. 2022

Ultrasonics Sonochemistry

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Section: Resultscontrasting

confidence: 57%

Antioxidant and anti-inflammatory polyphenols in ultrasound-assisted extracts from salvilla (Buddleja scordioides Kunth)

Macías-Cortés

Gallegos‐Infante

Rocha‐Guzmán

et al. 2022

Ultrasonics Sonochemistry

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“…In the mentioned paper [28], the Ames test and the micronucleus assay were used to evaluate the genotoxicity of P. filicifolia extracts and no genotoxic effect was observed. Stich et al [29] described clastogenic activity of CGA; however, Alarcón-Herrera et al [30] reported that CGA in the dose of 100 mg/kg in the micronuclues assay in vivo has no genotoxic effect. Maistro et al [31] reported the genotoxicity of CA and FA in concentrations of 500 and 1500 µM.…”

Section: Discussionmentioning

confidence: 99%

Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of Polyscias filicifolia Shoots Cultivated In Vitro

et al. 2020

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Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. Polyscias filicifolia Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of P. filicifolia contain a wide range of biologically active compounds like phenolic acids and triterpenoid saponins. In the present study. antigenotoxic potential of three naturally occurring phenolic acids and extracts of P. filicifolia growing in vitro with the addition of elicitors was evaluated against direct (4-nitroquinoline-N-oxide (4NQO) and mitomycin C (MMC)) and indirect mutagens (2-aminoanthracene (2AA)). The evaluation was made using a bacterial umu-test. Moreover, the ability to prevent photogenotoxicity induced by chlorpromazine (CPZ) under UVA irradiation was measured. The phytochemical profiling of examined extracts revealed the presence of numerous compounds with the prevelance of chlorogenic, caffeic, and ferulic acid derivatives; however, saponin fractions were also determined. The antioxidant potential of extracts strictly correlated with their composition. The tested extracts exhibited high antigenotoxic activity if the assay was performed with 2AA and metabolic activation. Moreover, the extracts slightly decreased the MMC-induced genotoxicity. However, an increase of the genotoxic effect was observed in the assay performed with 4NQO. In addition, photo-antigenotoxic activity was observed. In our study, phenolic acids exhibited lower activity than the extracts.

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“…It is also suggested that the ability of carnosine and agmatine to ameliorate the effects of MG, either directly or following upregulation of antioxidant defences may also contribute to their efficacy towards ASD. It is interesting to note that two of propionic acid's likely metabolites, 3-nitropropionate [96] and propionaldehyde [97], have also been associated with ASD; both carnosine and agmatine, could theoretically antagonise either their formation and/or toxicity via inhibiting propionate nitration or promoting aldehyde scavenging.…”

Section: Discussionmentioning

confidence: 99%

Energy metabolism and autism: the ameliorative potential of carnosine and agmatine

Ar¹

2018

Neurol Disord Therap

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Recent studies have revealed that autistic spectrum disorders (ASD) is associated with enhanced glycolysis (i.e. establishment of the Warburg effect) accompanied by increased formation of glycated proteins in sera and urine. Both carnosine and agmatine levels in sera of autistic individuals are reported to be lower than in control subjects. Carnosine and agmatine can influence cellular energy metabolism, in part via effects on mTOR, thereby decreasing glycolysis and enhancing mitochondrial activity and thus countering onset of Warburg-like metabolism: other mechanisms including suppressing methylglyoxal toxicity are also discussed. Dietary supplementation studies with carnosine and arginine (agmatine precursor) indicate ameliorative activity towards behaviour in ASD subjects. It is suggested that co-administration of carnosine and agmatine should be explored as a potential route for ASD amelioration.

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Protective effects of chlorogenic acid in 3-nitropropionic acid induced toxicity and genotoxicity

Cited by 23 publications

References 39 publications

Antioxidant and anti-inflammatory polyphenols in ultrasound-assisted extracts from salvilla (Buddleja scordioides Kunth)

Antioxidant and anti-inflammatory polyphenols in ultrasound-assisted extracts from salvilla (Buddleja scordioides Kunth)

Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of Polyscias filicifolia Shoots Cultivated In Vitro

Energy metabolism and autism: the ameliorative potential of carnosine and agmatine

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