Protective effects of Co-Q10, Ginkgo biloba, and l-carnitine on brain, kidney, liver, and endocrine system against sub-acute heavy metals toxicity in male rats

Abdulidha, Noor Ali; Jaccob, Ausama Ayob; AL-Moziel, Muhsin S. G.

doi:10.1007/s13530-020-00061-7

Cited by 9 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cd‐induced neurotoxicity leads to disruption of HCO3 − reabsorption (Johri et al, 2010), which may cause ion imbalances and thereby impact the pH of egg components, as observed in the current study. Regarding kidney function, CoQ10 supplementation has been shown to provide significant protection against Cd‐induced histopathological changes and improve renal function in rats (Abdulidha et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The effect of dietary coenzyme Q10 supplementation on egg quality and liver histopathology of layer quails under cadmium challenge

Rafieian‐Naeini

Zhandi

Sadeghi

et al. 2022

Animal Physiology Nutrition

View full text Add to dashboard Cite

The demand for quail eggs has been increased over the last decade due to its beneficial nutritional quality characteristics; however, different nutritional and environmental stressors adversely impact the quality of the produced eggs. This study was conducted to investigate whether dietary supplementation of coenzyme Q10 (CoQ10) could mitigate the negative impact of cadmium (Cd) administration on egg quality and liver histopathology. A total of 162 six-week-old laying Japanese quail (Coturnix japonica) were randomly allotted into three experimental groups.Treatments were as follows: (1) negative control (NC): feeding basal diet; (2) positive control (PC): feeding basal diet and Cd administration; and (3) CdQ10: feeding basal diet supplemented with CoQ10 (900 mg/kg diet) and Cd administration. Cadmium (10 mg/kg BW) was subcutaneously administrated at 10 and 11 weeks of age (woa). Feed conversion ratio (FCR), egg production, egg mass, mortality rate, Cd residue in egg, liver histopathology, and some internal and external egg quality indices were evaluated. Administration of Cd increased FCR in the PC group, but supplementation of CoQ10 partially ameliorated the impact of Cd on FCR (p < 0.05). Cadmium administration decreased both egg production and egg mass; however, CoQ10 supplementation partially mitigated these adverse effects of Cd injection in the CdQ10 compared to the PC group (p < 0.05). Cadmium decreased eggshell thickness and Haugh unit in PC quail compared to both NC and CdQ10 quail (p < 0.05). Moreover, egg yolk colour intensity was enhanced by CoQ10, where a* and b* indices were higher in CdQ10 compared to PC (p < 0.05). In conclusion, the current results demonstrate the beneficial effects of dietary CoQ10 supplementation on liver histopathology and some egg quality indices of Cd-challenged quail.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of dietary coenzyme Q10 supplementation on egg quality and liver histopathology of layer quails under cadmium challenge

Rafieian‐Naeini

Zhandi

Sadeghi

et al. 2022

Animal Physiology Nutrition

View full text Add to dashboard Cite

show abstract

“…In the present study, taxifolin and vitamin C administration showed synergistic effect regarding cardiac protection. Previous studies indicated the use of combinations of flavonoids, polyphenols and vitamins in the prevention of different disorders [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective and antioxidant effects of taxifolin and vitamin C against diazinone-induced myocardial injury in rats

Najeb¹,

Jaccob

AL-Moziel

et al. 2022

Environ Anal Health Toxicol

Self Cite

View full text Add to dashboard Cite

In Iraq, excessive exposure to insecticides is increasingly becoming uncontrollable, the objective of this work was to assess the possible ameliorative role of taxifolin and vitamin c against diazinon-induced myocardial injury in rats. 36 sprague female rats divided into 6 groups of 6 rats each. Group 1 received diazinone 20 mg/kg gavaged for 30 days. Group 2 received taxifolin (25 mg/kg) and vitamin C (100 mg /kg) co-administered together and gavaged daily for 30 days before oral diazinone (20 mg/kg). Group 3 and group 4 were treated with taxifoline (25 mg/kg) and vitamin C (100 mg /kg) respectively, gavaged separately for 30 days before diazinone (20 mg/kg) administration. group 5 was considered as control 1 received taxifolin (25 mg/kg) and vitamin C (100 mg /kg) co-administered together and gavaged daily for 30 days. The last group, group 6 considered as control 2 which received vehicle of diazinon. Rats’ weights, water and food intake were measured and the general vital signs of rats were observed and noted. At the end of study, rats are sacrificed, blood withdrawn for biochemical analysis and heart were excised for glutathione peroxidase and pathological evaluation. Significant increase in body weights in all treated and control groups except group 1. Troponin, LDH, AST and ALT levels were significantly increased in group 1 revealing the existence of ischemia and damage in hearts. Treatment with taxifolin and vitamin C combination reduced their levels significantly to concentrations comparable to that in the control groups. Such finding supported by histopathological observation. Moreover, this study showed that diazinon administration significantly deteriorated lipid profile, co-administration of taxifolin and vitamin C was resulted in a significant improvement in lipid profile associated with increased in glutathione peroxidase values showing significant improvement in antioxidant levels. Sub-acute administration of pharmacological doses of taxifolin and vitamin C exerts cardioprotective effects against diazinon-induced myocardial injury in rats.

show abstract

“… Bayril et al. (2020) reported that CoQ10 has anti-inflammatory impacts in birds subjected to cold stress by constraining nitric oxide, tumor necrosis factor-α (TNF-α), IL-1β, and mitogenic protein kinases; which may indicate that CoQ10 as a probably potent anti-inflammatory drug ( Abdulidha et al., 2020 ). In addition, CoQ10 is considered to be a powerful antioxidative agent; predominantly, the reactive oxygen species gathering, and subsequently testicular oxidative injury in Leydig cells by a particular chemical oxidant, might fail their response and performance to produce testosterone.…”

Section: Discussionmentioning

confidence: 99%

“…Throughout past years, numerous studies with various success levels have been performed to discover the impacts of dietary antioxidants on enhancing the poultry reproductive efficiency against oxidative stress ( Lukanov, 2019 ; Rafieian-Naeini et al., 2022 ). Co-enzyme Q10 ( CoQ10 ), likewise identified as ubiquinone, is a lipid-soluble substance and a vitamin-like nutrient mainly situated in mitochondria, where it has a significant part in the manufacture of adenosine triphosphate ( Abdulidha et al., 2020 ). CoQ10 also has the exceptional capability to perform as a potent free radical scavenger fat-soluble antioxidant, therefore restraining the damage related to oxidative stress ( Mollaei et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…As well as directly deactivating free radicals, CoQ10 can retain antioxidants like vitamin C (ascorbate) and vitamin E (α-tocopherol) ( Bayril et al, 2020 ). Below 5% of administrated orally, CoQ10 is assumed to spread to the blood circulation, and higher levels of CoQ10 in the plasma are required to stimulate peripheral tissue absorption ( Abdulidha et al., 2020 ). Nevertheless, there are no records of significant harmful impacts of CoQ10 administration ( Abdeen et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Coenzyme Q10 enhances testicular functions and sexual behavior through regulating steroidogenic-related gene expression and inflammatory pathways of Japanese quail (Coturnix japonica) aganist cadmium

Hafez¹,

El-kazaz²,

Ghamry³

et al. 2023

Poultry Science

View full text Add to dashboard Cite

Protective effects of Co-Q10, Ginkgo biloba, and l-carnitine on brain, kidney, liver, and endocrine system against sub-acute heavy metals toxicity in male rats

Cited by 9 publications

References 38 publications

The effect of dietary coenzyme Q10 supplementation on egg quality and liver histopathology of layer quails under cadmium challenge

The effect of dietary coenzyme Q10 supplementation on egg quality and liver histopathology of layer quails under cadmium challenge

Cardioprotective and antioxidant effects of taxifolin and vitamin C against diazinone-induced myocardial injury in rats

Coenzyme Q10 enhances testicular functions and sexual behavior through regulating steroidogenic-related gene expression and inflammatory pathways of Japanese quail (Coturnix japonica) aganist cadmium

Contact Info

Product

Resources

About