Protective effects of Coenzyme Q10 against acute pancreatitis

Shin, Joon Yeon; Choi, Jong‐Soo; Kim, Dong-Gu; Zhou, Zi Qi; Shin, Yong Kook; Seo, Jae Ho; Song, Ho‐Joon; Choi, Byung-Min; Bae, Gi‐Sang; Park, Sung‐Joo

doi:10.1016/j.intimp.2020.106900

Cited by 17 publications

(9 citation statements)

References 64 publications

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“…In a recent study, Q10 was also shown to reduce pancreatic acinar cell death, parenchymal edema, and inflammatory cell infiltration in the rat model of AP [ 31] .…”

Section: Discussionmentioning

confidence: 91%

The Beneficial Effects of Lipoic Acid Versus Coenzyme Q10 on Arginine-Induced Acute Pancreatitis in Albino Rats: Histological and Immunohistochemical study

Elsyade

Fattah²,

Khaled³

et al. 2021

Journal of Medical Histology

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Background: Acute pancreatitis (AP) is a self-limiting condition to a widespread, deadly multi-organ failure that can result in death. Objectives: To compare the protective effect of alpha lipoic acid (ALA) and Coenzyme (Q10) in an experimental rat model of L-arginine-induced AP. Materials (Subjects): Forty adult male albino rats were randomized equally into 4 groups: (i) The control group; (ii) The AP group received L-Arginine by intraperitoneal (IP) injection in two doses of 2 g/kg body weight each, 1 hour apart, (iii) The ALA+AP group was injected with L-Arginine and intramuscular (IM) injection of ALA in two doses of 60mg/kg body weight; 1 hour before L-arginine injection and 24 hours after the second dose of L-arginine; (iii) The Coenzyme Q10+AP group was injected with L-Arginine and IM injection of Q10 in two doses of 30mg/kg body weight; 1 hour before L-arginine injection and 24 hours after the second dose of L-arginine. Histological, immunohistochemical for HSP70 and NF-κB, and morphometric studies were done followed by statistical analysis. Results: AP group showed significant distortion of the pancreatic acini with obvious cellular damage while those treated by ALA and Coenzyme Q 10 especially ALA showed significant pancreatic tissue improvement as shown by HSP70 and NF-κB immunoexpressing. Conclusions: ALA and Q 10 therapy proved a clear protective effect in suppressing experimentally generated AP in male albino rats, but the improvement was more obvious with ALA.

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“…In a recent study, Q10 was also shown to reduce pancreatic acinar cell death, parenchymal edema, and inflammatory cell infiltration in the rat model of AP [ 31] .…”

Section: Discussionmentioning

confidence: 91%

The Beneficial Effects of Lipoic Acid Versus Coenzyme Q10 on Arginine-Induced Acute Pancreatitis in Albino Rats: Histological and Immunohistochemical study

Elsyade

Fattah²,

Khaled³

et al. 2021

Journal of Medical Histology

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“…This result is consistent with another study which demonstrated that β-carotene inhibited Erk1/2 in breast cancer MCF-7 cells (90). It has been reported that CoQ10 inhibited activation of Ras-Raf-Mek-Erk signaling pathway in various cell types, such as fibroblasts and endothelial cells (93)(94)(95). Since the inhibitory effect of CoQ10 on the signaling pathway has been more established, the present study examined the effect of CoQ10 on the Ras-Raf-Mek-Erk signaling pathway.…”

Section: Discussionmentioning

confidence: 97%

Effect of antioxidants coenzyme Q10 and β‑carotene on the cytotoxicity of vemurafenib against human malignant melanoma

Huang

Luo

et al. 2021

Oncol Lett

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Melanoma is a type of highly invasive skin cancer derived from melanocytes with poor prognosis. Vemurafenib (PLX4032) is a clinically approved targeted therapeutic for BRAF mutant melanoma that has a high therapeutic response rate and significantly prolongs the overall survival time of patients with melanoma. Antioxidants have been widely used as supplements for cancer prevention and for decreasing the side effects of cancer therapy. However, antioxidants can also protect cancer cells from oxidative stress and promote cancer growth and progression. The present study aimed to examine the effect of the antioxidants coenzyme Q10 (CoQ10) and β-carotene on melanoma cell growth and invasiveness and on the cytotoxicity of vemurafenib against both vemurafenib-sensitive (SK-MEL-28) and vemurafenibresistant (A2058) human malignant melanoma cell lines. MTS assay and wound-healing assay demonstrated that CoQ10 alone significantly reduced the viability and migration of melanoma cells, respectively, and synergistically worked with vemurafenib to decrease the viability and migration of human melanoma cells. In contrast, MTS assay and flow cytometry revealed that β-carotene alone did not affect the viability and apoptosis induction of melanoma cells; however, it inhibited cell migration and invasiveness. Wound-healing and Transwell assay demonstrated that β-carotene alleviated the cytotoxicity of vemurafenib and mitigated the inhibitory effect of vemurafenib on cell migration and invasion. Both CoQ10 and β-carotene protected melanoma cells from undergoing apoptosis induced by vemurafenib. Immunoblotting demonstrated that β-carotene at physiological concentration worked synergistically with vemurafenib to suppress the Ras-Raf-Mek-Erk intracellular signaling pathway. The present study aimed to add to the evidence of the in vitro effects of CoQ10 and β-carotene on the antimelanoma effects of vemurafenib.

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“…They should be included in the design and evaluation of nutritional and pharmaceutical interventions for cancer, neurodegeneration, erythro-poiesis, and AP treatment. This may be a promising strategy to reverse the disease [15,28,42] …”

Section: Ferroptosis and Apmentioning

confidence: 99%

“…Q10 may cause extracellular signal-regulated kinase and c-jun NH2-terminal kinase inactivation of AP attenuation. [42]…”

Section: Nadph-fsp1-coq10 Pathwaymentioning

confidence: 99%

“…This may be a promising strategy to reverse the disease. [15,28,42] (2) Lipophagy: Another example of the autophagyferroptosis relationship is lipophagy induction, where lipid droplets (mediated by the receptor RAB7A) are degraded into free fatty acids that can be oxidized. The upregulation of TPD52 promotes the formation of lipid droplets, thereby preventing ferroptosis caused by lipid peroxidation.…”

Section: Autophagymentioning

confidence: 99%

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Ferroptosis and its emerging roles in acute pancreatitis

Lin

Zhang

et al. 2022

Chinese Medical Journal

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Acute pancreatitis (AP) is a common and potentially life-threatening pancreatic inflammatory disease. Although it is usually selflimiting, up to 20% of patients will develop into severe AP. It may lead to systemic inflammatory response syndrome and multiple organ dysfunction, affecting the lungs, kidneys, liver, heart, etc. Surviving patients usually have sequelae of varying degrees, such as chronic hyperglycemia after AP (CHAP), pancreatic exocrine insufficiency, and chronic pancreatitis. Lacking specific target treatments is the main reason for high mortality and morbidity, which means that more research on the pathogenesis of AP is needed. Ferroptosis is a newly discovered regulated cell death (RCD), originally described in cancer cells, involving the accumulation of iron and the depletion of plasma membrane polyunsaturated fatty acids, and a caspase-independent RCD. It is closely related to neurological diseases, myocardial infarction, ischemia/reperfusion injury, cancer, etc. Research in the past years has also found the effects of ferroptosis in AP, pancreatic cancer, and AP complications, such as acute lung injury and acute kidney injury. This article reviews the research progress of ferroptosis and its association with the pathophysiological mechanisms of AP, trying to provide new insight into the pathogenesis and treatment of AP, facilitating the development of better-targeted drugs.

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Protective effects of Coenzyme Q10 against acute pancreatitis

Cited by 17 publications

References 64 publications

The Beneficial Effects of Lipoic Acid Versus Coenzyme Q10 on Arginine-Induced Acute Pancreatitis in Albino Rats: Histological and Immunohistochemical study

The Beneficial Effects of Lipoic Acid Versus Coenzyme Q10 on Arginine-Induced Acute Pancreatitis in Albino Rats: Histological and Immunohistochemical study

Effect of antioxidants coenzyme Q10 and β‑carotene on the cytotoxicity of vemurafenib against human malignant melanoma

Ferroptosis and its emerging roles in acute pancreatitis

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