Protective effects of curcumin on biochemical and molecular changes in sodium arsenite‐induced oxidative damage in embryonic fibroblast cells

Perker, Mehmet Can; Yılmaz, Banu Orta; Yildizbayrak, Nebahat; Aydın, Yasemin; Erkan, Melike

doi:10.1002/jbt.22320

Cited by 17 publications

(5 citation statements)

References 37 publications

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“…Similar results were observed in embryonic fibroblasts coexposed to sodium arsenite and bioactive compounds from turmeric for 24 h, which evidenced increased cell viability and reduced oxidative stress in comparison with cultures only exposed to arsenite. Then, this study suggests that polyphenols can play a protective role in the presence of toxic agents [81].…”

Section: Discussionmentioning

confidence: 78%

The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts

et al. 2023

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Fibroblasts contribute to maintaining tissue integrity and homeostasis and are a key cell population in wound healing. This cell population can be stimulated by some bioactive compounds such as extra virgin olive oil (EVOO) polyphenols. The aim of this study was to determine the effects of hydroxytyrosol (htyr), tyrosol (tyr), and oleocanthal (ole) phenolic compounds present in EVOO on the proliferation, migration, cell cycle, and antigenic profile of cultured human fibroblasts. CCD-1064Sk human fibroblast cells were treated for 24 h with each polyphenol at doses ranging 10−5 to 10−9 M. Cell proliferation was evaluated using the MTT spectrophotometric technique, migration capacity by culture insert assay, and cell cycle and antigenic profile with flow cytometry. Cell proliferation was significantly increased by treatment with all compounds. The highest increases followed treatments with htyr or tyr at doses of 10−5 or 10−6 M and with ole at 10−6 and 10−7 M, and these compounds and doses were used for assays of antigenic profile, cell cycle, and migration. During the first few hours after treatment, increased fibronectin and α-actin expressions and greater cell migration were observed, with no cell cycle changes. In conclusion, these in vitro results suggest that phenolic compounds in EVOO might contribute to wound healing through action on fibroblasts related to tissue regeneration.

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Section: Discussionmentioning

confidence: 78%

The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts

et al. 2023

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“…NaAsO2 directly affects the antioxidant enzymes (SOD, Cat, GPx, and GST) and regulation of antioxidant genes (SOD1, Cat, and GPx1) in embryonic fibroblast cells and caused oxidative damage through increasing the cellular levels of hydrogen peroxide, hydroxyl radical and LPO. It has been found that CUR potentially improved antioxidant system genes and enzymes to defend the fibroblast cell toxicity created by NaAsO2 [214].…”

Section: 6other Arsenic Induced-pathologic Conditionsmentioning

confidence: 99%

Counteracting arsenic toxicity: Curcumin to the rescue?

Bahrami

Sathyapalan

Moallem

et al. 2020

Journal of Hazardous Materials

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Arsenicosis leads to various irreversible damages in several organs and is considered to be a carcinogen. The effects of chronic arsenic poisoning are a result of an imbalance between pro-and antioxidant homeostasis, oxidative stress, as well as DNA and protein damage .Curcumin, the polyphenolic pigment extracted from the rhizome of Curcuma longa , is well-known for its pleiotropic medicinal effects. Curcumin has been shown to have ameliorative effects in arsenic-induced genotoxicity, nephrotoxicity, hepatotoxicity, angiogenesis, skin diseases, reproductive toxicity, neurotoxicity, and immunotoxicity. This review aims to summarize the scientific evidence on arsenic toxicity in various organs and the ameliorative effects of curcumin on the arsenic toxicity.

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“…Similar inconsistent conclusions also existed for the combined effects of curcumin and other heavy metals. Negligible protective effects of curcumin could be observed when combating the cytotoxicity elicited by As in embryonic fibroblast cells [ 34 ], however, curcumin was proved to decline the As-induced mortality rate by 40% in PC12 cells [ 35 ]. As a promising antidote with high efficiency and excellent biocompatibility, it is of great value to systematically evaluate the detoxification effect of curcumin against different typical heavy metals under the same experimental standards.…”

Section: Introductionmentioning

confidence: 99%

The Differential Antagonistic Ability of Curcumin against Cytotoxicity and Genotoxicity Induced by Distinct Heavy Metals

Liu

Sun

Wang

et al. 2023

Toxics

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Widespread heavy metal pollution has aroused severe health risks worldwide. Curcumin has been reported to play a wide-spectrum protective role for various heavy metals. However, the specificity and difference in the antagonistic ability of curcumin against distinct types of heavy metals are still largely unknown. Here, using cadmium (Cd), arsenic (As), lead (Pb), and nickel (Ni) as the typical heavy metals, we systematically compared the detoxification efficiency of curcumin on the cytotoxicity and genotoxicity elicited by different heavy metals under the same experimental conditions. Curcumin was proved to have a significant discrepant antagonistic capacity when counteracting the adverse effect of different heavy metals. Stronger protective effects of curcumin emerged when antagonizing the toxicity of Cd and As, rather than Pb and Ni. Curcumin exhibits a better detoxification ability against heavy metal-induced genotoxicity than cytotoxicity. Mechanistically, inhibiting the oxidative stress elicited by heavy metals and reducing the bioaccumulation of metal ions both contributed to the detoxification of curcumin against all the tested heavy metals. Our results illustrated that curcumin shows prominent detoxification specificity against different types of heavy metals and toxic endpoints, which provides a new clue for the better and targeted application of curcumin in heavy metal detoxification.

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Protective effects of curcumin on biochemical and molecular changes in sodium arsenite‐induced oxidative damage in embryonic fibroblast cells

Cited by 17 publications

References 37 publications

The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts

The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts

Counteracting arsenic toxicity: Curcumin to the rescue?

The Differential Antagonistic Ability of Curcumin against Cytotoxicity and Genotoxicity Induced by Distinct Heavy Metals

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