Protective effects of curcumin on ischemia/reperfusion injury

Mohamadian, Malihe; Parsamanesh, Negin; Chiti, Hossein; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1002/ptr.7620

Cited by 14 publications

(7 citation statements)

References 268 publications

(351 reference statements)

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“…Histopathological evaluation indicated that hesperitin alleviated IR-induced kidney injury in mice. Treatment of mice with hesperetin significantly reduced renal injury (P<0.05) in comparison to the IR group [27]. Histopathological examination of the mouse kidney tissue showed swelling and cystic renal tubule; dilatation with interstitial inflammation were apparent when contrast with the sham group.…”

Section: Effect Of Hesperetin On Renal Parenchymamentioning

confidence: 84%

Hesperetin Alleviate Renal Ischemia-Reperfusion Injury in Male Mice Model by Suppressing Inflammation & Oxidative Stress Pathway

Jabbar,

Mekkey,

Sahib

et al. 2023

ijmst

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Reports indicate that renal injury or damage results in high mortality. Aim: To evaluate the beneficial aspects of hesperetin in treating kidney injury in male mice caused by ischemia-reperfusion (IR). Materials and Method: Twenty-eight male Swiss Albino mice with weight range of 35–38 g at 12–16 weeks old were gathered into 4 groups; each group had seven mice, as follows: group I (sham group) undergone all research surgical techniques, with the exception of the use of vascular clamps for occlusion and reperfusion on the pedicles. group II (IR group) was subjected to reperfusion and ischemia. group III (DMSO group), Hesperetin's solvent is (DMSO)dimethyl sulfoxide was subjected to intraperitoneal injection of 1.5 mg/kg of DMSO 30 min prior to the exposure to renal IR processes under anesthesia. group IV (hesperetin treated group) was subjected to intraperitoneal injection of 50 mg/kg of hesperetin 30 min before being subjected to IR procedures while sedated. Mice underwent euthanization, and then a blood sample from the heart was taken to measure the levels of urea, creainine, MDA, and glutathione peroxidase (GPx) in the serum. Bilateral nephroctomy was performed and the kidney sample underwent homogenization so that the tissue markers can be measured (IL1 and IL6). A part of the kidney sample was placed in paraffin blocks with a 10% formalin solution. and prepared for histological examination. Results: The results demonstrated that the average (mean) tissue levels of (IL1, IL6, and MDA), also the mean serum concentration of (urea and creatinine) and the histopathological changes scores compared to the sham group, increased significantly (P< 0.05) in the IR group, while the activity of glutathione peroxidase (P < 0.05) was reduced compared with other groups. In the hesperetin treated group, the mean levels of IL1, IL6, and MDA as well as the mean urea and creatinine levels in the blood underwent significant (P<0.05) reduction. Similarly, the histopathological changes scores were decreased, while the glutathione peroxidase (P < 0.05) activity was higher compare with other groups Hesperetin reduces kidney injury caused by ischemia and reperfusion through their pleiotropic effects by modulating the inflammation pathway and oxidative activity.

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Section: Effect Of Hesperetin On Renal Parenchymamentioning

confidence: 84%

Hesperetin Alleviate Renal Ischemia-Reperfusion Injury in Male Mice Model by Suppressing Inflammation & Oxidative Stress Pathway

Jabbar,

Mekkey,

Sahib

et al. 2023

ijmst

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“…Especially in hepatic ischemia models, many studies have been carried out and many agents have been used to minimize the resulting ischemic liver injury and subsequent reperfusion injury. However, since liver ischemia-reperfusion injury has not been clari ed yet, it is important to understand the pathophysiology of liver I/R-related diseases in the clinic and to reveal different treatment modalities for these diseases (Mohamadian et al 2022).…”

Section: )mentioning

confidence: 99%

Effect of Thymoquinon on TRPM Channels in Rats with Liver Ischemia

Caglar

Tümer

Tutuk

et al. 2023

Preprint

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Ischemia/Reperfusion (I/R) injury is surgery and clinically important problem. It was showed that Ca+ 2 concentration increases into cell with I/R injury. TRPM channels have a role in determining the amount of Ca+ 2 concentration into cell. Thymoquinone (Tmq) which was isolated from Nigella Sativa, particularly has the beneficial effects such as antioxidant, anticancerogenic, antiinflamatuar. We aimed to investigate the antioxidant and histopathologic effect of thymoquinone in hepatic I/R rat model. In addition the other purpose of the our study was determination effects of thymoquinone on levels of TRPM gene expression. Fifty Wistar rats were divided into 5 groups. Group 1: Control; Group 2: Shame; Group 3: Hepatic I/R (45min/45min); Group 4: Tmq (50 mg/kg); Group 5: Tmq + I/R (ten days before from I/R at dose 50 mg/kg of Tmq by oral gavage.) Hepatic I/R (45min/45min) model was performed at the portal vein and the hepatic artery with atraumatic vascular a clamp in ischemia groups. The liver tissues and blood samples which were taken at the end of study were evaluated for histopathologic and biochemical analysis. Besides TRPM gene expression levels were determined in liver tissues. It was seen that cellular swelling, congestion, PNL and apoptosis parameters statistically decreased in Tmq and Tmq + I/R groups in comparision with I/R group in histopathological evaluation. It was obsorved that biochemical parameters, AST, ALT, GGT, LDH, creatinine and urea levels significantly increased in I/R group as compared with, shame, Tmq and Tmq + I/R groups. It was found that TRPM2,6,7,8 gene expression decreased significantly in Tmq + I/R groups as compared to I/R group. Based on our findings it was observed that application of Tmq in the treatment of liver diseases associated with I/R injury is important in terms of both ischemia and apoptosis and also using in the treatment of liver-related diseases. Additionally we showed that thymoquinone may inhibit Ca+ 2 entry into the cell by reducing TRPM2,6,7,8 gene expression. In conclusion this situation is brought to mind that cell injury related with I/R is reduced by Tmq.

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“…Physiotherapy needs professional medical equipments and it usually acts affiliated role in treating IRI. Although pharmacological therapies are various, combinating different mechanisms drugs can exert the best therapeutic effectiveness and some of these durgs have serious side effects ( Mohamadian et al, 2022 ). However, as a classic and popular type of TCM, curcumin has gained a great attention for its multiple mechanisms such as antioxidant, anti-inflammatory, suppressing Ca 2+ overload and mediating autophagy et al Therefore, due to its distinctive and various pharmacological properties, curcumin might be the promosing candidate for the treatment of IRI.…”

Section: Therapeutic Approaches For Irimentioning

confidence: 99%

“…2 Therapeutic approaches for IRI Current therapeutic approaches are various and its foundations are alleviating ischemia and restoring reperfusion (Mohamadian et al, 2022). Therapeutic approaches can be divided into surgery, physiotherapy and pharmacology.…”

Section: Introductionmentioning

confidence: 99%

Role of curcumin in ischemia and reperfusion injury

Zhang

2023

Front. Pharmacol.

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Ischemia-reperfusion injury (IRI) is an inevitable pathological process after organic transplantations. Although traditional treatments restore the blood supply of ischemic organs, the damage caused by IRI is always ignored. Therefore, the ideal and effective therapeutic strategy to mitigate IRI is warrented. Curcumin is a type of polyphenols, processing such properties as anti-oxidative stress, anti-inflammation and anti-apoptosis. However, although many researches have been confirmed that curcumin can exert great effects on the mitigation of IRI, there are still some controversies about its underlying mechanisms among these researches. Thus, this review is to summarize the protective role of curcumin against IRI as well as the controversies of current researches, so as to clarify its underlying mechanisms clearly and provide clinicians a novel idea of the therapy for IRI.

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Protective effects of curcumin on ischemia/reperfusion injury

Cited by 14 publications

References 268 publications

Hesperetin Alleviate Renal Ischemia-Reperfusion Injury in Male Mice Model by Suppressing Inflammation & Oxidative Stress Pathway

Hesperetin Alleviate Renal Ischemia-Reperfusion Injury in Male Mice Model by Suppressing Inflammation & Oxidative Stress Pathway

Effect of Thymoquinon on TRPM Channels in Rats with Liver Ischemia

Role of curcumin in ischemia and reperfusion injury

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