Protective Effects of Different Marigold &lt;i&gt;(Calendula officinalis L.)&lt;/i&gt; and Rosemary Cream Preparations against Sodium-Lauryl-Sulfate-Induced Irritant Contact Dermatitis

Fuchs, S.; Schliemann‐Willers, S.; Fischer, Tobias W.; Elsner, Peter

doi:10.1159/000085865

Cited by 30 publications

(16 citation statements)

References 29 publications

(14 reference statements)

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“…While we did not observe any inhibition with calendula oil, other studies have documented its positive contribution to wound healing [27-30]. Calendula is associated with lymphocyte activation [15], angiogenesis [30], and alleviation of irritations [31], so it is plausible that its role in healing is due primarily to immune modulation and stimulation of tissue repair rather than antimicrobial activity.…”

Section: Resultscontrasting

confidence: 48%

In Vitro efficacy of antimicrobial extracts against the atypical ruminant pathogen Mycoplasma mycoides subsp. capri

Arjoon

Saylor

May

2012

BMC Complement Altern Med

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BackgroundMycoplasmosis is a common infection in human and veterinary medicine, and is associated with chronic inflammation and high morbidity. Mycoplasma species are often intrinsically resistant to many conventional antimicrobial therapies, and the resistance patterns of pathogenic mycoplasmas to commonly used medicinal (antimicrobial) plant extracts are currently unknown.MethodsAqueous extracts, ethanol extracts, or oils of the targeted plant species and colloidal silver were prepared or purchased. Activity against the wall-less bacterial pathogen Mycoplasma mycoides subsp. capri was determined and compared to activities measured against Escherichia coli and Bacillus subtilis. Antimicrobial susceptibility testing was performed by broth microdilution assays. The lethal or inhibitory nature of each extract was determined by subculture into neat growth medium.ResultsGrowth of M. mycoides capri, E. coli, and B. subtilis was inhibited by elderberry extract, oregano oil, ethanol extract of oregano leaves, and ethanol extract of goldenseal root. No inhibition was seen with aqueous extract of astragalus or calendula oil. Growth of M. mycoides capri and B. subtilis was inhibited by ethanol extract of astragalus, whereas growth of E. coli was not. Similarly, M. mycoides capri and E. coli were inhibited by aqueous extract of thyme, but B. subtilis was unaffected. Only B. subtilis was inhibited by colloidal silver. Measured MICs ranged from 0.0003 mg/mL to 3.8 mg/mL. Bacteriostatic and bactericidal effects differed by species and extract.ConclusionsThe atypical pathogen M. mycoides capri was sensitive to extracts from many medicinal plants commonly used as antimicrobials in states of preparation and concentrations currently available for purchase in the United States and Europe. Variation in bacteriostatic and bactericidal activities between species and extracts indicates that multiple effecter compounds are present in these plant species.

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Section: Resultscontrasting

confidence: 48%

In Vitro efficacy of antimicrobial extracts against the atypical ruminant pathogen Mycoplasma mycoides subsp. capri

Arjoon

Saylor

May

2012

BMC Complement Altern Med

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“…In particular, attention has been drawn to faradiol monoester and unesterfied faradiol, whose anti-inflammatory activities have been found to be of the same order of magnitude as that of indomethacin [18] . It has been claimed that these compounds play an important role in the anti-inflammatory properties of C. officinalis extracts [18,27,29,31,33] , and our chemical analysis of the investigated extract revealed the presence of unesterified faradiol and mainly lauryl, myristoyl and palmitoyl monoesters, which were the most abundant components.…”

Section: Discussionmentioning

confidence: 66%

“…The anti-inflammatory effects of C. officinalis extracts have been documented for topical applications using the croton oil-induced edema of the mouse ear test [18,[29][30][31] . A wound-healing activity [32] and protective effects in irritant contact dermatitis and in acute dermatitis during irradiation have also been reported [33,34] . A concentration-dependent reduction in lipid peroxidation has been observed in vitro [16,17] and in vivo tests of the inhibition of superoxide generation in mouse macrophages [17] , and by an increase in catalase activity after oral administration [17] .…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of <i>Calendula officinalis</i> Extract: Inhibitory Effects on Chemiluminescence of Human Neutrophil Bursts and Electron Paramagnetic Resonance Spectroscopy

et al. 2009

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There is growing interest in natural chemical compounds from aromatic, spicy, medicinal and other plants with antioxidant properties in order to find new sources of compounds inactivating free radicals generated by metabolic pathways within body tissue and cells, mainly polymorphonuclear leukocytes (PMNs) whose overregulated recruitment and activation generate a large amount of reactive oxygen species (ROS) and reactive nitrogen species (RNS), leading to an imbalance of redox homeostasis and oxidative stress. The aim of this study was to examine whether a propylene glycol extract of Calendula officinalis interferes with ROS and RNS during the PMN respiratory bursts, and to establish the lowest concentration at which it still exerts antioxidant activity by means of luminol-amplified chemiluminescence. Electron paramagnetic resonance (EPR) spectroscopy was also used in order to confirm the activity of the C. officinalis extract. The C. officinalis extract exerted its anti-ROS and anti-RNS activity in a concentration-dependent manner, with significant effects being observed at even very low concentrations: 0.20 μg/ml without L-arginine, 0.10 μg/ml when L-arginine was added to the test with phorbol 12-myristate 13-acetate and 0.05 μg/ml when it was added to the test with N-formyl-methionyl-leucyl-phenylalanine. The EPR study confirmed these findings, 0.20 μg/ml being the lowest concentration of C. officinalis extract that significantly reduced 2,2-diphenyl-1-picrylhydrazyl. These findings are interesting for improving the antioxidant network and restoring the redox balance in human cells with plant-derived molecules as well as extending the possibility of antagonizing the oxidative stress generated in living organisms when the balance is in favor of free radicals as a result of the depletion of cell antioxidants.

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“…(1996), showed positive preliminary results for the administration of calendula ointment in the treatment of venous leg ulcers [47]. It has been demonstrated that calendula as a cream preparation protected skin from irritant contact dermatitis caused by exposure to sodium lauryl sulfate [48]. And as earlier mentioned, calendula was highly effective in the prevention of acute dermatitis in patients with cancer undergoing postoperative irradiation [12].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study

et al. 2013

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This study was designed to determine the effect of Calendula officinalis flowers extract mouthwash as oral gel on radiation-induced oropharyngeal mucositis (OM) in patients with head-and-neck cancer. Forty patients with neck and head cancers under radiotherapy or concurrent chemoradiotherapy protocols were randomly assigned to receive either 2% calendula extract mouthwash or placebo (20 patients in each group). Patients were treated with telecobalt radiotherapy at conventional fractionation (200 cGy/fraction, five fractions weekly, 30–35 fractions within 4–7 weeks). The oropharyngeal mucositis was evaluated by two clinical investigators (a radiation oncologist and a dentist), using the oral mucositis assessment scale (OMAS). Trying to find out the possible mechanism of action of the treatment, total antioxidant, polyphenol and flavonoid contents, and quercetin concentration of the mouth wash were measured. Calendula mouthwash significantly decreased the intensity of OM compared to placebo at week 2 (score: 5.5 vs. 6.8, p = 0.019), week 3 (score: 8.25 vs. 10.95, p < 0.0001) and week 6 (score: 11.4 vs. 13.35, p = 0.031). Total antioxidant, polyphenol and flavonoid contents and quercetin concentration of the 2% extract were 2353.4 ± 56.5 μM, 313.40 ± 6.52 mg/g, 76.66 ± 23.24 mg/g, and 19.41 ± 4.34 mg/l, respectively. Calendula extract gel could be effective on decreasing the intensity of radiotherapy- induced OM during the treatment and antioxidant capacity may be partly responsible for the effect.

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Protective Effects of Different Marigold <i>(Calendula officinalis L.)</i> and Rosemary Cream Preparations against Sodium-Lauryl-Sulfate-Induced Irritant Contact Dermatitis

Cited by 30 publications

References 29 publications

In Vitro efficacy of antimicrobial extracts against the atypical ruminant pathogen Mycoplasma mycoides subsp. capri

In Vitro efficacy of antimicrobial extracts against the atypical ruminant pathogen Mycoplasma mycoides subsp. capri

Antioxidant Activity of <i>Calendula officinalis</i> Extract: Inhibitory Effects on Chemiluminescence of Human Neutrophil Bursts and Electron Paramagnetic Resonance Spectroscopy

Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study

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