Protective Effects of Downregulating Estrogen Receptor Alpha Expression in Cervical Cancer

Yu, Ping; Wang, Yuping; Li, Chuan-Xun; Lv, Li; Wang, Jihong

doi:10.2174/1871520618666180830162517

Cited by 7 publications

(6 citation statements)

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“…In vivo studies by Chung and Lambert (2009) suggested that estrogen might be involved in the carcinogenesis of CC. Epidemiological data ( Chung et al, 2010 ; Bronowicka-Kłys et al, 2016 ; Yu et al, 2018 ) also confirmed that women with the highest serum estrogen levels had an increased risk of CC. Therefore, estrogen might be another potential mechanism mediated by the gut microbiota affecting CC.…”

Section: Discussionmentioning

confidence: 75%

The causal correlation between gut microbiota abundance and pathogenesis of cervical cancer: a bidirectional mendelian randomization study

Yang

2024

Front. Microbiol.

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BackgroundObservational studies and animal experiments suggested potential relevance between gut microbiota (GM) and cervical cancer (CC), but the relevance of this association remains to be clarified.MethodsWe performed a two-sample bidirectional Mendelian randomization (MR) analysis to explore whether there was a causal correlation between GM and CC, and the direction of causality.ResultsIn primary outcomes, we found that a higher abundance of class Clostridia, family Family XI, genus Alloprevotella, genus Ruminiclostridium 9, and order Clostridiales predicted higher risk of CC, and a higher abundance of class Lentisphaeria, family Acidaminococcaceae, genus Christensenellaceae R7 group, genus Marvinbryantia, order Victivallales, phylum Actinobacteria, and phylum Lentisphaerae predicted lower risk of CC. During verifiable outcomes, we found that a higher abundance of class Methanobacteria, family Actinomycetaceae, family Methanobacteriaceae, genus Lachnospiraceae UCG 010, genus Methanobrevibacter, order Actinomycetales, and order Methanobacteriales predicted a higher risk of CC, and a higher abundance of family Streptococcaceae, genus Dialister, and phylum Bacteroidetes predicted a lower risk of CC, and vice versa.ConclusionOur study implied a mutual causality between GM and CC, which provided a novel concept for the occurrence and development of CC, and might promote future functional or clinical analysis.

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Section: Discussionmentioning

confidence: 75%

The causal correlation between gut microbiota abundance and pathogenesis of cervical cancer: a bidirectional mendelian randomization study

Yang

2024

Front. Microbiol.

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“…It may also be indicated that ERα and ERβ regulate processes connected with the female reproductive system in regulating several other physiological and pathophysiological processes in the human body. Disrupted ER signaling leads to the development of different diseases, such as osteoporosis, neurodegeneration, inflammation and metabolic and cardiovascular diseases [ 19 ]; however, the most important indications to modify their activity connected with estrogen-related cancers such as breast [ 19 ], endometrial [ 20 ], cervical [ 21 ] and ovarian cancer [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…This is because more than half of breast cancers are ERα overexpressing, and about 70% of them respond to antiestrogen therapy (for example, tamoxifen). On the other hand, an increased expression of ERα and ERβ in benign breast epithelium seems to indicate an increased risk of breast cancer, suggesting a role for ERα in breast cancer initiation and progression [ 19 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

Resveratrol Analogues as Selective Estrogen Signaling Pathway Modulators: Structure–Activity Relationship

et al. 2022

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Resveratrol is a plant-derived phytoalexin found in grapes, red wine and many other plants used in Asian folk medicine. It is extensively studied for pleiotropic biological activity. The most crucial are anticancer and chemopreventive properties. Resveratrol has also been reported to be an antioxidant and phytoestrogen. The phytoestrogenic activity of resveratrol was assayed in different in vitro and in vivo models. Although these works brought some, on the first look, conflicting results, it is commonly accepted that resveratrol interacts with estrogen receptors and functions as a mixed agonist/antagonist. It is widely accepted that the hydroxyl groups are crucial for resveratrol’s cytotoxic and antioxidative activity and are responsible for binding estrogen receptors. In this work, we assayed 11 resveratrol analogues, seven barring methoxy groups and six hydroxylated analogues in different combinations at positions 3, 4, 5 and 3′,4′,5′. For this purpose, recombined estrogen receptors and estrogen-dependent MCF-7 and Ishikawa cells were used. Our study was supported by in silico docking studies. We have shown that, resveratrol and 3,4,4′5′-tetrahydroxystilbene, 3,3′,4,5,5′-pentahydroxystilbene and 3,3′,4,4′,5,5′-hexahydroxystilbene may act as selective estrogen receptor modulators.

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“…It is now recognized that ERa is a key regulator of energy homeostasis and glucose metabolism and that the ERa pathway might represent a potential therapeutic target for the prevention or treatment of insulin resistance, type 2 diabetes mellitus, and non-alcoholic fatty liver diseases [16,32]. On the other hand, ERa is linked with a variety of cancers and metastases, including breast cancer, cervical cancer, lung carcinoma, and prostate cancer [33][34][35][36].…”

Section: Eramentioning

confidence: 99%

Estrogen and estrogen receptors in kidney diseases

Chen

2021

Renal Failure

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Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to global health within this century. Studies have suggested that estrogen and estrogen receptors (ERs) play important roles in many physiological processes in the kidney. For instance, they are crucial in maintaining mitochondrial homeostasis and modulating endothelin-1 (ET-1) system in the kidney. Estrogen takes part in the kidney repair and regeneration via its receptors. Estrogen also participates in the regulation of phosphorus homeostasis via its receptors in the proximal tubule. The ERa polymorphisms have been associated with the susceptibilities and outcomes of several renal diseases. As a consequence, the altered or dysregulated estrogen/ERs signaling pathways may contribute to a variety of kidney diseases, including various causes-induced AKI, diabetic kidney disease (DKD), lupus nephritis (LN), IgA nephropathy (IgAN), CKD complications, etc. Experimental and clinical studies have shown that targeting estrogen/ERs signaling pathways might have protective effects against certain renal disorders. However, many unsolved problems still exist in knowledge regarding the roles of estrogen and ERs in distinct kidney diseases. Further research is needed to shed light on this area and to enable the discovery of pathwayspecific therapies for kidney diseases.

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Protective Effects of Downregulating Estrogen Receptor Alpha Expression in Cervical Cancer

Abstract: Downregulating ER-α expression may be a potential treatment regimen for cervical cancer patients and will be of great significance for patients with cervical cancer who are receiving conventional treatment for nonsurgical treatments.

Cited by 7 publications

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The causal correlation between gut microbiota abundance and pathogenesis of cervical cancer: a bidirectional mendelian randomization study

The causal correlation between gut microbiota abundance and pathogenesis of cervical cancer: a bidirectional mendelian randomization study

Resveratrol Analogues as Selective Estrogen Signaling Pathway Modulators: Structure–Activity Relationship

Estrogen and estrogen receptors in kidney diseases

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