1998
DOI: 10.1016/s0278-6915(98)00035-0
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Protective Effects of Fruits and Vegetables against In Vivo Clastogenicity of Cyclophosphamide or Benzo[a]pyrene in Mice

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Cited by 30 publications
(16 citation statements)
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“…In this context, an important focus of the search is to understand the true effi cacy of plant materials and determine its mechanism of action in different experimental models (RomeroJiménez et al, 2005). Although human body is equipped with self defense mechanisms such as detoxifi cation process through various enzymes, serious exposure to dangerous chemicals can cause changes in the genetic material (mutations) leading to carcinogenic events (Edenharder et al, 1998;Belitsky & Yakubovskaya, 2008). Cyclophosphamide (CP), an antineoplastic agent, and its metabolites can bind DNA, causing damage that may result in chromosome breaks, micronucleus formation and cell death (Murata et al, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…In this context, an important focus of the search is to understand the true effi cacy of plant materials and determine its mechanism of action in different experimental models (RomeroJiménez et al, 2005). Although human body is equipped with self defense mechanisms such as detoxifi cation process through various enzymes, serious exposure to dangerous chemicals can cause changes in the genetic material (mutations) leading to carcinogenic events (Edenharder et al, 1998;Belitsky & Yakubovskaya, 2008). Cyclophosphamide (CP), an antineoplastic agent, and its metabolites can bind DNA, causing damage that may result in chromosome breaks, micronucleus formation and cell death (Murata et al, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…1 Many natural compounds in plants have been reported to have potential protective effects on these diseases as well as anticarcinogenic effects. 2 Medicinal plants have potential preventive properties because of chemical constituents such as phenolic compounds and flavonoids. Flavonoids and phenolic compounds have many biological properties, including hepa toprotective, antibacterial, and anticancer activity.…”
Section: Introductionmentioning
confidence: 99%
“…In vivo micronucleus test can be a useful short term test the serving explanation of the mechanisms and the identification of chemical compounds responsible for anticlastogenic effect. EDENHARDER et al (1998) proved anticlastogenic effects of fruits and vegetables, commonly consumed in Germany, against benzo(a)pyrene and cyclophosphamide. Similar effects were confirmed in the subsequent study (EDENHARDER et al 2003).…”
Section: Discussionmentioning
confidence: 99%