Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging

Jing, Rongrong; Guo, Keke; Zhong, Yulan; Wang, Lusheng; Zhao, Jungang; Gao, Bingyan; Ye, Ziyi; Chen, Yu; Li, Xue-Nan; Xu, Nuo; Xuan, Xuan

doi:10.21037/atm-21-3668

Cited by 18 publications

(10 citation statements)

References 51 publications

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“…79 Studies proved that UVA-irradiation decreased the activation of the AMPK/ SIRT-1/PGC-1α pathway in HaCaT cells and HFF-1 cells. 80 The present study also found the mRNA and protein expression of AMPK, SIRT-1, and PGC-1α decreased in UVB-induced skin damage. Other research using human dermal fibroblasts and a 3D skin model to evaluate the effect of Aquatide on UV-induced skin aging found that Aquatide upregulated the expression of FOXO1 by activating the expression of SIRT-1.…”

supporting

confidence: 77%

β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

Zhou

Du²,

Long

et al. 2021

JIR

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Ultraviolet light is an important environmental factor that induces skin oxidation, inflammation, and other diseases. Nicotinamide mononucleotide (NMN) has the effect of antioxidation and improving various physiological processes. This study explores the protective effect of NMN monomers given via intraperitoneal injection on UVB-induced photodamage. Methods:We used a murine model of UVB-induced photodamage to evaluate the effect of an NMN monomer on photoaging skin by assessing skin and liver tissue sections, serum and skin oxidative stress levels, inflammatory markers, mRNA expression, and protein expression of skin-and liver-related genes. Results:The results showed that NMN treatment blocked UVB-induced photodamage in mice, maintaining normal structure and amount of collagen fibers, normal thickness of epidermis and dermis, reducing the production of mast cells, and maintaining complete organized skin structure. NMN intraperitoneal injection also maintained the normal morphology of the mouse liver after UVB exposure. Meanwhile, NMN intraperitoneal injection was found to increase antioxidant ability and regulate the proinflammatory response of the skin and liver to UVB irradiation by enhancing the activity of antioxidant enzymes, release of anti-inflammatory cytokines, reduction of hydrogen peroxide production (H 2 O 2 ), and decreased inflammatory cytokines. Furthermore, RT-qPCR results indicated that NMN reduced oxidative stress of skin and liver by promoting the activation of the AMP-activated protein kinase (AMPK) signaling pathway and further increasing the expression of downstream antioxidant genes of AMPK. RT-qPCR results also revealed that NMN treatment could downregulate the mRNA expression of interleukin (IL)-6, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, and upregulate NF-kappa-B inhibitor-α (IκB-α) and interleukin (IL)-10 by inhibiting the activation of nuclear factor-κBp65 (NFκB-p65). Finally, NMN upregulated AMPK, IκB-α, SOD1, and CAT in the skin and downregulated NF-κBp65 protein expression, which is in line with the RT-qPCR results. Conclusion: Based on the above results, NMN monomer treatment with intraperitoneal injection also block the photodamage caused by UVB irradiation in mice by regulating the oxidative stress response and inflammatory response.

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supporting

confidence: 77%

β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

Zhou

Du²,

Long

et al. 2021

JIR

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“…Fucoidan is a sulfated polysaccharide found in large quantities in the cell wall. It has the potential to be employed as an antioxidant, anticancer, anti-angiogenic, antiphotoaging and antitumor drug, according to several in vitro investigations (Cong et al 2016;Jing et al 2021;Palanisamy et al 2018; Shannon et al 2021;Shen et al 2017). Mannitol is a monosaccharide found in the cytoplasm of brown seaweeds.…”

Section: Brown Seaweedsmentioning

confidence: 99%

Global seaweed farming and processing in the past 20 years

Zhang

Liao

Huang

et al. 2022

Food Prod Process and Nutr

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Seaweed has emerged as one of the most promising resources due to its remarkable adaptability, short development period, and resource sustainability. It is an effective breakthrough to alleviate future resource crises. Algal resources have reached a high stage of growth in the past years due to the increased output and demand for seaweed worldwide. Several aspects global seaweed farming production and processing over the last 20 years are reviewed, such as the latest situation and approaches of seaweed farming. Research progress and production trend of various seaweed application are discussed. Besides, the challenges faced by seaweed farming and processing are also analyzed, and the related countermeasures are proposed, which can provide advice for seaweed farming and processing. The primary products, extraction and application, or waste utilization of seaweed would bring greater benefits with the continuous development and improvement of applications in various fields. Graphical Abstract

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“…The low-molecular-weight fucoidan and its derivatives show high antioxidant capacity [ 31 ]. Although some studies reported that the functional properties of sulfated polysaccharides failed to characterize the structural properties [ 28 ], fucoidan refined from marine algae was widely studied in in vitro skin care studies [ 14 , 17 , 32 , 33 ]. Specifically, the anti-inflammatory effect of fucoidan on FD-stimulated epidermal cells [ 14 ], the mixture of TNF-α and IFN-γ-stimulated epidermal cells [ 17 ], and the antioxidative effect of fucoidan on UVB-stimulated epidermal cells [ 32 , 33 ] were reported.…”

Section: Discussionmentioning

confidence: 99%

“…Although some studies reported that the functional properties of sulfated polysaccharides failed to characterize the structural properties [ 28 ], fucoidan refined from marine algae was widely studied in in vitro skin care studies [ 14 , 17 , 32 , 33 ]. Specifically, the anti-inflammatory effect of fucoidan on FD-stimulated epidermal cells [ 14 ], the mixture of TNF-α and IFN-γ-stimulated epidermal cells [ 17 ], and the antioxidative effect of fucoidan on UVB-stimulated epidermal cells [ 32 , 33 ] were reported. The anti-inflammatory mechanism of fucoidan via cyclooxygenase 2 (COX2) inhibition [ 34 ], NF-κB signaling inhibition in the Wistar rat models [ 35 ], MAPK signaling inhibition in cerebral ischemia-reperfusion injured rat model [ 36 ], and regulating chemokines and cytokines secretion [ 17 ] were identified in recent studies.…”

Section: Discussionmentioning

confidence: 99%

Fine-Dust-Induced Skin Inflammation: Low-Molecular-Weight Fucoidan Protects Keratinocytes and Underlying Fibroblasts in an Integrated Culture Model

et al. 2022

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Prolonged exposure to fine dust (FD) increases the risk of skin inflammation. Stimulated epidermal cells release growth factors into their extracellular environment, which can induce inflammation in dermal cells. Algae are considered rich sources of bioactive materials. The present study emphasized the effect of low-molecular-weight fucoidan isolated from Sargassum confusum (LMF) against FD-induced inflammation in HaCaT keratinocytes and underneath fibroblasts (HDFs) in an integrated culture model. HDFs were treated with media from FD-stimulated HaCaT with LMF treatments (preconditioned media). The results suggested that FD increased the oxidative stress in HaCaT, thereby increasing the sub-G1 phase of the cell cycle up to 587%, as revealed via flow cytometric analysis. With preconditioned media, HDFs also displayed oxidative stress; however, the increase in the sub-G1 phase was insignificant compared with HaCaT. LMF dose-dependently regulated the NF-κB/MAPK signaling in HaCaT. Furthermore, significant downregulation in NF-κB/MAPK signaling, as well as inflammatory cytokines, tissue inhibitors of metalloproteinases, matrix metalloproteinases, and reduction in relative elastase and collagenase activities related to the extracellular matrix degeneration were observed in HDFs with a preconditioned media treatment. Therefore, we concluded that HDFs were protected from inflammation by preconditioned media. Continued research on tissue culture and in vivo studies may reveal the therapeutic potential of LMF.

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Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging

Cited by 18 publications

References 51 publications

β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

Global seaweed farming and processing in the past 20 years

Fine-Dust-Induced Skin Inflammation: Low-Molecular-Weight Fucoidan Protects Keratinocytes and Underlying Fibroblasts in an Integrated Culture Model

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