Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway

Nguyen, Thuy Le Lam; Huynh, Diem Thi Ngoc; Jin, Yujin; Jeon, Hyesu; Heo, Kyung‐Sun

doi:10.1007/s12272-020-01304-4

Cited by 37 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, triptriolide could alleviate LPS‐induced oxidative stress and inflammation by regulating the Nrf2 and NF‐κB signaling pathways in the liver (Yang et al., 2018 ). Similar to our findings, G‐Rg2 and ‐Rh1 exerts a protective effect on liver function through inhibiting the TAK1 and STAT3‐mediated inflammatory activity and the Nrf2/ ARE‑mediated antioxidant signaling pathway (Nguyen et al., 2021 ).…”

Section: Discussionsupporting

confidence: 91%

Protective effect of Salidroside on hypoxia‐related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways

Xiong

Wang

Teng

2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Protective effect of Salidroside on hypoxia‐related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways

Xiong

Wang

Teng

2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…On the other hand, studies have indicated that hesperidin potentially upregulates the antioxidant levels (HO‐1/SOD/GPx) by triggering the Nrf2/ARE pathway and increasing the nuclear phosphorylation of Nrf2 and thus protects against hepatotoxicity [70] and brain disorders [71,72] . Similarly, ginsenoside Rg2 was also proved to improve liver function via activating Nrf2 pathways in the liver [73] …”

Section: Resultsmentioning

confidence: 99%

Phytoconstituents of Sansevieria suffruticosa N.E.Br. Leaves and Its Hepatoprotective Effect via Activation of the NRF2/ARE Signaling Pathway in an Experimentally Induced Liver Fibrosis Rat Model

Abdel-Rahman¹,

Fayed²,

Ogaly

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

Sansevieria species possess antioxidant and hepatoprotective activities. However, the therapeutic potential of Sansevieria suffruticosa N.E.Br. in liver fibrosis was not evaluated yet. Twenty‐seven phytoconstituents were tentatively identified in the phytoconstituents profile of Sansevieria suffruticosa N.E.Br. leaves extract (SSLE) using high‐performance liquid chromatography coupled with mass spectrometry (HPLC‐ESI/MS‐MS). Using column chromatography, hesperetin, 4‐hydroxybenzoic acid, ginsenoside Rg2, and quinic acid were isolated from SSLE. The hepatoprotective effect of SSLE via the activation of the NRF2 signaling pathway was evaluated using a rat model of thioacetamide‐induced liver fibrosis. Five groups of 6 male adult Wistar rats were used. All animals except the normal control were injected with 200 mg/kg of TAA intraperitoneally twice weekly for 6 weeks. SSLE‐treated groups were orally administered 200 and 100 mg/kg/day of the extract, two weeks before the liver fibrosis induction and were continued concomitantly with TAA injection. A reference group received 100 mg/kg b.wt of silymarin orally. SSLE treated groups exhibited a marked reduction in serum alanine transaminase (ALT), aspartate transaminase (AST) and malondialdehyde (MDA) levels compared with the TAA group. The levels of reduced glutathione (GSH) content and hepatic mRNA levels of Nrf2 and HO‐1 were significantly increased. Histological findings further confirmed the protective role of SSLE against TAA. In conclusion, the aforementioned results indicated that the hepatoprotective mechanism of SSLE was exerted via activating the Nrf2 pathway to counteract oxidative stress.

show abstract

“…The effects of Rh1 on the expression of p-STAT3 and p-p65 was determined using immunofluorescence assay as described previously [ 41 ]. MDA-MB-231 cells were fixed with 4% paraformaldehyde for 10 min at RT and permeabilized with 0.1% Triton X-100 for 10 min.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rh1 Prevents Migration and Invasion through Mitochondrial ROS-Mediated Inhibition of STAT3/NF-κB Signaling in MDA-MB-231 Cells

Jin

Huynh

Myung

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Breast cancer (BC) a very common cancer in women worldwide. Triple negative breast cancer (TNBC) has been shown to have a poor prognosis with a high level of tumor metastatic spread. Here, the inhibitory effects of ginsenoside-Rh1 (Rh1) on BC metastasis, and its underlying signaling pathway in TNBC were investigated. Rh1-treated MDA-MB-231 cells were analyzed for metastasis using a wound healing assay, transwell migration and invasion assay, western blotting, and qRT-PCR. Rh1 treatment significantly inhibited BC metastasis by inhibiting the both protein and mRNA levels of MMP2, MMP9, and VEGF-A. Further, Rh1-mediated inhibitory effect on BC migration was associated with mitochondrial ROS generation. Rh1 treatment significantly eliminated STAT3 phosphorylation and NF-κB transactivation to downregulate metastatic factors, such as MMP2, MMP9, and VEGF-A. In addition, Mito-TEMPO treatment reversed Rh1 effects on the activation of STAT3, NF-κB, and their transcriptional targets. Rh1 further enhanced the inhibitory effects of STAT3 or NF-κB specific inhibitor, stattic or BAY 11-7082 on MMP2, MMP9, and VEGF-A expression, respectively. In summary, our results revealed the potent anticancer effect of Rh1 on TNBC migration and invasion through mtROS-mediated inhibition of STAT3 and NF-κB signaling.

show abstract

Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway

Cited by 37 publications

References 32 publications

Protective effect of Salidroside on hypoxia‐related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways

Protective effect of Salidroside on hypoxia‐related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways

Phytoconstituents of Sansevieria suffruticosa N.E.Br. Leaves and Its Hepatoprotective Effect via Activation of the NRF2/ARE Signaling Pathway in an Experimentally Induced Liver Fibrosis Rat Model

Ginsenoside Rh1 Prevents Migration and Invasion through Mitochondrial ROS-Mediated Inhibition of STAT3/NF-κB Signaling in MDA-MB-231 Cells

Contact Info

Product

Resources

About