Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats

Cui, Jing; Shan, Rui; Cao, Yanqi; Zhou, Yifa; Liu, Chunming; Fan, Yuying

doi:10.1016/j.jep.2020.113466

Cited by 41 publications

(21 citation statements)

References 36 publications

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“…Although Panax ginseng is a source of plenty of biological active compounds, the molecules with the greatest potential to become drug molecules are ginsenosides. According to data obtained from animal studies, ginsenosides have great potential to be used for the treatment of cardiovascular diseases, hepatic disorders and obesity [ 227 , 228 , 229 , 230 , 231 , 232 , 233 ]. According to data obtained from cell culture studies, ginsenosides have great potential to be used for the treatment cardiovascular diseases, hypercholesterolemia, and some types of cancer [ 234 , 235 , 236 , 237 ].…”

Section: Resultsmentioning

confidence: 99%

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

Todorova

Ivanov

Ivanova

2021

Plants

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Background: In the 1960s, research into plant adaptogens began. Plants with adaptogenic properties have rich phytochemical compositions and have been used by humanity since ancient times. However, it is not still clear whether the adaptogenic properties are because of specific compounds or because of the whole plant extracts. The aim of this review is to compare the bioactive compounds in the different parts of these plants. Methods: The search strategy was based on studies related to the isolation of bioactive compounds from Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus, and Panax ginseng. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results: This review includes data from 259 articles. The phytochemicals isolated from Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus, and Panax ginseng were described and classified in several categories. Conclusions: Plant species have always played an important role in drug discovery because their effectiveness is based on the hundreds of years of experience with folk medicine in different nations. In our view, there is great potential in the near future for some of the phytochemicals found in these plants species to become pharmaceutical agents.

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Section: Resultsmentioning

confidence: 99%

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

Todorova

Ivanov

Ivanova

2021

Plants

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“…Other studies have confirmed that ginsenoside Rg2, one of the most important active components of ginsenosides, significantly inhibits the apoptosis of Aβ treated PC12 cells by up-regulating the PI3K/AKT signaling pathway, which may be caused by the decrease of ROS and intracellular Ca 2+ concentration by ginsenoside, the activation of autophagy pathway, the up-regulation of Bcl-2 and the down-regulation of Bax ( Cui et al, 2017a ). Taken together, ginsenosides are deemed as potential new drugs for the treatment of AD ( Cui et al, 2020 ).…”

Section: Natural Products For Prevention and Treatment Of Alzheimer’s Disease Based On Pi3k/akt Pathawymentioning

confidence: 99%

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

et al. 2021

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Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.

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“…The present study had the merit to examine the integration of several diseases in the elderly. However, each disease status was induced by surgical interventions and may not be entirely representative of the related disorders in elderly people, although each induced disease in rats showed similar symptoms as a human disease (20,21,27) . The present study was designed to show the interaction of inflammation between the peripheral tissues and the brain, even though they are not directly connected.…”

Section: Discussionmentioning

confidence: 99%

“…Ovariectomised (OVX) Sprague-Dawley rats aged over 8 weeks, when finishing puberty, have exhibited similar symptoms as menopausal women, but without unrelated symptoms of ageing (18,19) . When they have an amyloid-β injection in the hippocampus, they also develop Alzheimer's disease-like symptoms (20) ; likewise, monoidoacetate (MIA) injection into their knee joints causes OA symptoms (21) . Therefore, OVX Sprague-Dawley female rats aged 10 weeks were chosen as an oestrogen-deficient animal model to examine the effects of diet and food restriction on AD exacerbated OA.…”

mentioning

confidence: 99%

Intermittent fasting with a high-protein diet mitigated osteoarthritis symptoms by increasing lean body mass and reducing inflammation in osteoarthritic rats with Alzheimer’s disease-like dementia

Park

Shin²

2021

Br J Nutr

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Menopausal women are susceptible to osteoarthritis and memory impairment. We hypothesized that Alzheimer’s-like disease (AD) exacerbates osteoarthritis and that intermittent fasting(IMF) with a high-protein(H-P) diet would enhance memory function and relieve osteoarthritis symptoms in estrogen-deficient animals with surgically induced AD and osteoarthritis. The action mechanism was also explored. Ovariectomized Sprague-Dawley rats were fed high-fat(H-F) or H-P diets for two weeks, and then they had a hippocampal infusion of β-amyloid(25-35) for 4 weeks to induce AD and an injection of monoidoacetate(MIA) into the articular cartilage to induce osteoarthritis. Four groups had AD symptoms, whereas two groups had non-AD symptoms by hippocampal amyloid-β(35-25) infusion. All rats had an MIA injection into the articular cartilage of the left knee. IMF suppressed memory impairment in AD rats, especially those fed H-P diets. Compared to Non-AD, AD exacerbated osteoarthritis symptoms, including swelling, limping, slowed treadmill running speed, and uneven weight distribution in the left leg. The exacerbations were linked to increased inflammation and pain, but IMF and H-P lessened inflammation and pain-related symptoms. Lean body mass(LBM) also decreased with AD and IMF, but H-P protected against LBM loss. Histological examination of the knee joint revealed the degree of the cellular invasion into the middle zone, and the changes in the tidemark plateau were greatest in the AD-AL with H-F, while non-AD-IMF improved the cellular invasion to as much as non-AD-AL. H-P reduced the infiltration into the middle-zone of the knee and promoted collagen production. In conclusion, AD exacerbated the articular cartilage deterioration and memory impairment, and IMF with H-P alleviated the memory impairment and osteoarthritic symptoms by decreasing hippocampal amyloid-β deposition and proinflammatory cytokine expressions and by increasing LBM.

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Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats

Cited by 41 publications

References 36 publications

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Intermittent fasting with a high-protein diet mitigated osteoarthritis symptoms by increasing lean body mass and reducing inflammation in osteoarthritic rats with Alzheimer’s disease-like dementia

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