Protective effects of <i>Crataegus azarolus</i> L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Sammari, Houcem; Jedidi, Saber; Selmi, H.; Rtibi, Kaïs; Jabri, Mohamed-Amine; Jridi, Mourad; Zouari, Nacim; Toumi, Lamjed; Sebaï, Hichem

doi:10.1111/nmo.14065

Cited by 20 publications

(12 citation statements)

References 67 publications

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“…In fact, we previously showed that the Crataegus azarolus berries aqueous extract obtained by maceration contained a lower level of total phenolic contents than the decoction extract for the same plant part. 40 Our results are in line with the findings of Castro-López et al 41 In addition, the LC-ESI-MS analysis resulted in the identification of 8 phenolic compounds, among which chlorogenic acid was the major component. In this respect, previous reports demonstrated that this fruit has a very diverse phenolic profile.…”

Section: Discussionsupporting

confidence: 91%

Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats

Sammari,

Jedidi,

Selmi

et al. 2024

Dose-Response

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The present study aims to evaluate the protective effect of Crataegus azarolus berries decoction extract (CAB-DE) against acetic acid-induced ulcerative colitis as well as the mechanisms implicated in such protection. Adult male Wistar rats were separated into seven groups: Control (H2O), acetic acid (AA), AA + various doses of CAB-DE (100, 200, and 400 mg/kg, b.w.,p.o.), and AA + sulfasalazine (100 mg/kg, b.w.,p.o.) or gallic acid (50 mg/kg, b.w.,p.o.) during 10 days. All rats were kept fasting overnight and ulcerative colitis was induced by rectal infusion of AA (300 mg kg−1, b.w.) (3%, v/v, 5 mL kg−1 b.w), for 30 s. The colon was rapidly excised and macroscopically examined to measure ulcerated surfaces and the ulcer index. In vitro, we found that CAB-DE exhibited a high antioxidant activity against DPPH radical (IC50 = 164.17 ± 4.78 μg/mL). In vivo , pretreatment with CAB-DE significantly protected the colonic mucosa against AA-induced damage by stimulating mucus secretion, reducing ulcer index as well as histopathological changes. Also, CAB-DE limited the oxidative status induced by AA in the colonic mucosa, as assessed by MDA and H2O2 increased levels and the depletion of both enzymatic activities and non-enzymatic levels. In addition, AA intoxication increased iron and calcium levels in colonic mucosa and plasma, while CAB-DE pretreatment regulated all intracellular mediators deregulation and significantly reduced inflammatory markers such as CRP (1.175 ± .04 ─ .734 ± .06 μg/dl) and ALP (161.53 ± 5.02 ─ 98.60 ± 4.21 UI/L) levels. We suggest that CAB-DE protected against AA-induced ulcerative colitis due in part to its antioxidant and anti-inflammatory properties.

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Section: Discussionsupporting

confidence: 91%

Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats

Sammari,

Jedidi,

Selmi

et al. 2024

Dose-Response

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“…Among the several mechanisms to explain the laxative effect of castor oil, one is the inhibition of intestinal Na+/K + -ATPase activity. Thus, reducing normal fluid absorption through activation of adenylate cyclase or mucosal cyclic adenosine monophosphate-mediated active secretion and nitric oxide release [ 23 , 24 ]. Moreover, castor oil promotes smooth muscle contraction via its metabolite, ricinoleic acid.…”

Section: Discussionmentioning

confidence: 99%

Evaluations of the in vivo laxative effects of aqueous root extracts of Euclea racemosa L. in mice

2023

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“…However, the inhibition produced by the standard drug, loperamide, was more than that produced by the extract. Castor oil-induced diarrhea have been shown in previous studies to be inhibited by many plant extracts such as Crataegus azarolus, [35] Bixa orellana, [36] Vitex doniana, [37] and Entada africana. [38] In an attempt to suggest other possible mechanism of activity of the plant extract, the PE 2 enteropooling test was carried out.…”

Section: Discussionmentioning

confidence: 99%

Antidiarrheal and Antioxidant Activities of the Aerial Parts of Caralluma dalzielii N. E. Brown

Ugwah‐Oguejiofor¹,

Mshelia²,

Bello³

et al. 2021

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Background: Caralluma dalzielii N.E. Brown is commonly referred to as "Karan massalanci" in the Northwest Nigeria where it is used in treating several ailments including pain, diarrhea and stomach issues. Objectives: This study was aimed to investigate the antidiarrheal and antioxidant activities of aqueous aerial parts extract of Caralluma dalzielii. Materials and Methods: The aqueous aerial parts extract of Caralluma dalzielii (CDE) (100, 200 and 400 mg/kg) was evaluated for antidiarrheal properties against gastrointestinal motility, castor oil-induced and prostaglandin-E 2 (PGE2) enteropooling models in Wistar rats. Its antioxidant properties were studied by determining the total phenolic content (TPC) using Folin-Ciocalteu reagent, its free radical scavenging activity using 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH) and its ferric reducing antioxidant power (FRAP) assays using potassium ferrocyanide ferric chloride methods. Ascorbic acid was used as the reference. Spasmolytic effect was studied in isolated rabbit jejunum preparations in an organ bath experiment using acetylcholine (ACh). Results: CDE significantly (p<0.05) reduced gastrointestinal transit of charcoal meal and the total number of diarrheal feces in the animals. The total phenolic content was determined to be 36.67±3.33 mg GAE/g. IC 50 value of 63.44 mg/mL was calculated in DPPH assay. The FRAP value was found to increase as the concentration of the extract increased. CDE inhibited acetylcholine-induced contraction of the rabbit jejunum in a concentration dependent manner with complete inhibition at 20.48 mg/mL of the extract. Conclusion: The extract of Caralluma dalzielii possesses antidiarrheal activities which may be related to its antimotility, antioxidant and antispasmodic properties.

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Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Cited by 20 publications

References 67 publications

Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats

Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats

Evaluations of the in vivo laxative effects of aqueous root extracts of Euclea racemosa L. in mice

Antidiarrheal and Antioxidant Activities of the Aerial Parts of Caralluma dalzielii N. E. Brown

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