Protective effects ofFumaria parvifloraL. on lead-induced testicular toxicity in male rats

Abstract

In recent years, the clinical importance of herbal drugs has received considerable attention in reducing free radical-induced tissue injury. Oxidative stress has been proposed as a possible mechanism involved in lead toxicity that causes reproductive system failure in both human and animals. Fumaria parviflora L., a traditional herb, has been used to cure various ailments in Persian folk medicine. This study was carried out to investigate whether ethanolic extract of F. parviflora leaves could protect the male rats against lead-induced testicular oxidative stress. Adult Wistar rats were treated with 0.1% lead acetate in drinking water with or without 200 mg kg day(-1) F. parviflora extract via gavage for 70 days. Lead acetate treatment resulted in significant reduction in testis weight, seminiferous tubules diameter, epididymal sperm count, serum testosterone level, testicular content of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Moreover, significant elevation was observed in content of malondialdehyde (MDA) in lead-treated rats. However, co-administration of F. parviflora extract showed a significant increase in selected reproductive parameters in lead-treated rats. The results indicated that ethanolic extract of F. parviflora leaves has a potential to restore the suppressed reproduction associated with lead exposure and prevented lead-induced testicular toxicity in male Wistar rats.

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

“…Rubio et al (2006) have stated that severe effects of lead on function of male genital system occur through changes in spermatogenesis and sperm function [37]. Various Overall, results of the lead effects on sperms in the current study are similar to those from other recent investigations [5,7,9,38]. Significant decreases in Sertoli and Leydig cells, height of germinal epithelium and diameter of seminiferous tubules in rats have been reported [5,9,38].…”

“…Kakkar et al (2005) have shown that disorders in structure and function of male genital system and quality of sperms are principal symptoms of exposure to lead [8]. Lead can be absorbed through respiration, digestion and skin and accumulated in body [9]. Heavy metals such as lead can show their toxic effects through the production of reactive oxygen species (ROS) or inhibition of antioxidant enzyme activity [10,11].…”

The protective effect of arabic gum extract against lead acetate toxicity albino rats

“…In the present study lead acetate treatment resulted in an elevation in the level malondehyde and nitric oxide level and a decrease in the activity of catalase in testis tissue these findings are in accordance with those of (Dorostghoal, 2013;Sharma & Bhattacharya, 2015;Ansar et al, 2016) they attributed that to administration of lead, Lead can cross the blood-testis barrier, accumulate in the testis, and damage germinal cells at various levels of differentiationshifted the oxidant/antioxidant profile towards oxidant side as manifested by the marked exhaustion of the enzymatic antioxidants together with the accumulation of lipid peroxidation product in the testicular tissue homogenate. This was in corroboration with earlier reports (Ansar et al, 2016).…”

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

“…83 It has been reported phenolic compounds present in Fumaria parviflora leaves demonstrated significant protection against lead induced testicular oxidative stress in rats. 84 Cinnamon polyphenols witnessed significant protection against lead acetate induced reproductive toxicities in male rats. 85 Rich phenolic compounds present in Tribulus terrestris root extract and vitamin C have preventive role against lead acetate induced testicular toxicity in mice.…”