Protective Effects of Iridoid Glycoside from Corni Fructus on Type 2 Diabetes with Nonalcoholic Fatty Liver in Mice

Niu, Dou; Xue, Chen; Wang, Ting; Wang, Fuxing; Zhang, Qiusheng; Xue, Xiaochang; Kang, Jiefang

doi:10.1155/2021/3642463

Cited by 9 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These lipid-lowering and antioxidant effects of the plant can be attributed to the extract’s active metabolites. Several preclinical studies described these effects of flavonoids ( Gou et al, 2020 ; Hu et al, 2020 ; Liu et al, 2021 ), glycosides ( Bao et al, 2020 ; Kurek et al, 2021 ; Niu et al, 2021 ), and alkaloids ( Cheng et al, 2020 ; Li et al, 2020 ; Ramos et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…As expected, several animal models of MAFLD and alcoholic fatty liver disease have revealed increases in AST and ALT levels ( Lívero et al, 2014 , 2016 ; Barbosa et al, 2020 ; Souza et al, 2020 ; Mendes et al, 2021 ). The therapeutic effects of medicinal plants in reversing this increase in markers of liver damage are well described in the literature, especially the beneficial effects of flavonoids, glycosides, and alkaloids ( Ling et al, 2020 ; Zhang et al, 2020 ; Han et al, 2021 ; Niu et al, 2021 ; Ore et al, 2021 ; Sahlan et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Croton urucurana Baill. Ameliorates Metabolic Associated Fatty Liver Disease in Rats

et al. 2022

View full text Add to dashboard Cite

Background: Metabolic associated fatty liver disease (MAFLD) affects a quarter of the worldwide population, but no drug therapies have yet been developed. Croton urucurana Baill. (Euphorbiaceae) is a medicinal species, that is, widely distributed in Brazil. It is used in popular medicine to treat gastrointestinal, cardiovascular, and endocrine system diseases. However, its hepatoprotective and lipid-lowering effects have not yet been scientifically investigated.Aim of the study: The present study investigated the effects of an extract of C. urucurana in a rat model of MAFLD that was associated with multiple risk factors, including hypertension, smoking, and dyslipidemia.Material and Methods: The phytochemical composition of C. urucurana was evaluated by liquid chromatography-mass spectrometry. Spontaneously hypertensive rats received a 0.5% cholesterol-enriched diet and were exposed to cigarette smoke (9 cigarettes/day for 10 weeks). During the last 5 weeks, the animals were orally treated with vehicle (negative control [C-] group), C. urucurana extract (30, 100, and 300 mg/kg), or simvastatin + enalapril (two standard reference drugs that are commonly used to treat dyslipidemia and hypertension, respectively). One group of rats that were not exposed to these risk factors was also evaluated (basal group). Blood was collected for the analysis of cholesterol, triglyceride, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels. The liver and feces were collected for lipid quantification. The liver was also processed for antioxidant and histopathological analysis.Results: The main constituents of the C. urucurana extract were flavonoids, glycosides, and alkaloids. The model successfully induced MAFLD, reflected by increases in AST and ALT levels, and induced oxidative stress in the C- group. Treatment with the C. urucurana extract (300 mg/kg) and simvastatin + enalapril decreased plasma and hepatic lipid levels. In contrast to simvastatin + enalapril treatment, C. urucurana reduced AST and ALT levels. Massive lesions were observed in the liver in the C- group, which were reversed by treatment with the C. urucurana extract (300 mg/kg).Conclusion:C. urucurana extract exerted promising hepatoprotective and lipid-lowering effects in a preclinical rat model of MAFLD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Croton urucurana Baill. Ameliorates Metabolic Associated Fatty Liver Disease in Rats

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Iridoid extracts from Valeriana fauriei and Corni fructus were also demonstrated to be the main compounds contributing to the alleviation of hepatic steatosis in NAFLD in vivo models. Iridoids identified from V.…”

Section: Monoterpenoid-rich Componentsmentioning

confidence: 97%

“…115 Iridoid glycoside extract from C. fructus obtained via the methanol and alcohol extraction method has protective effects against type 2 diabetes with NAFLD in mice by significantly reducing inflammation (CRP, TNF-α, IL-6, COX-2, and iNOS), oxidative stress (MDA, T-AOC, T-SOD, and GSH-Px), insulin resistance, and fat accumulation through inhibiting TAK1/NF-κB and activating PI3K/Akt/GSK3β signaling pathways. 116 Finally, we could look at two traditional Chinese herbal medicines Qushi Huayu decoction 117 and Yi̅ n-Cheń-Ha ̅ o decoction, 118 which are also used for NAFLD in clinical practice. The main active components of Qushi Huayu decoction are geniposide and chlorogenic acid, and those of Yi̅ n-Cheń-Ha ̅ o decoction are chlorogenic acid, rhein, geniposide, emodin, and scoparone.…”

Section: ■ Monoterpenoid-rich Componentsmentioning

confidence: 99%

Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases

Zhang

Lin

Cheng

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

The protective effect of plant active ingredients against non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prominent, and the terpenoids have always been the main active compounds in Chinese herbal medicine exerting hepatoprotective effects. However, the related pharmacological effects, especially for monoterpenoids or iridoid glycosides, which have obvious effects on improvement of NAFLD, have not been systematically analyzed. The objective of this review is to systematically examine the molecular mechanisms of monoterpenoids in NAFLD. The signaling pathways of peroxisome proliferator-activated receptor, insulin, nuclear factor κB, toll-like receptor, adipocytokine, RAC-α serine/threonine protein kinase, mammalian target of rapamycin, 5′-AMP-activated protein kinase, and autophagy have been proven to mediate this protective effect. We further compared the experimental data from animal models, including the dosage of these monoterpenoids in detail, and demonstrated that they are effective and safe candidate drugs for NAFLD. This review provides a reference for the development of NAFLD drugs as well as a research guideline for the potential uses of plant monoterpenoids.

show abstract

“…36 The short-term protective effect of digitoxin against sepsis-induced ALI was also associated with inflammation and oxidative stress. 37 Moreover, the anti-inflammatory and antioxidative functions of iridoid glycoside from Corni Fructus, including CIG, 38 morroniside, 39 and loganin, 40 have been demonstrated in the type 2 diabetic model. In addition, morroniside also inhibited inflammation and oxidative stress in lipopolysaccharideadministered RAW 264.7 macrophages.…”

Section: Competing Interestsmentioning

confidence: 99%

Cornus iridoid glycoside alleviates sepsis-induced acute lung injury by regulating NF-κB and Nrf2/HO-1 pathways

Tang

2022

Allergol Immunopathol

View full text Add to dashboard Cite

Background: Sepsis-induced acute lung injury (ALI) is a syndrome associated with inflammation. Cornus iridoid glycoside (CIG), a bioactive component isolated from Corni Fructus, exhibits anti-inflammatory activities. However, the function and underlying mechanisms of CIG in mice with sepsis-induced ALI remain elusive. Methods: The sepsis-elicited ALI model of mice was established by the induction of cecal ligation and puncture (CLP). The wet/dry (W/D) ratio of lung tissues was examined, and the pathological alterations were determined by hematoxylin and eosin staining. The messenger RNA (mRNA) expressions and serum levels of Interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured by reverse transcription-quantitative polymerase chain reaction and enzyme-linked immunosorbent serologic assay, respectively. The concentrations of malondial-dehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were assessed by biochemical kits. In addition, the relative protein levels of p-p65, p65, phosphorylated-nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (p-IκBα), IκBα, nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) gene were analyzed by Western blotting analysis. Results: CLP enhanced W/D ratio and aggravated pathological changes and scores in mice, which were obviously alleviated by the two concentrations of CIG treatment. CIG treatment notably decreased the CLP-induced mRNA expressions and serum levels of IL-1β, IL-6, TNF-α, and MDA, but enhanced the decreased concentrations (caused by CLP) of SOD and GSH-Px. Moreover, CIG treatment significantly decreased the ratios of p65/p-p65 and IκBα/p-IκBα caused by CLP, but aggravated the CLP-induced relative protein levels of Nrf2 and HO-1. Conclusions: CIG obviously ameliorated the sepsis-induced ALI in mice by suppressing inflammation and oxidative stress, which was closely associated with nuclear factor kappa B (NF-κB) and Nrf2–HO-1 signaling pathways.

show abstract

Protective Effects of Iridoid Glycoside from Corni Fructus on Type 2 Diabetes with Nonalcoholic Fatty Liver in Mice

Cited by 9 publications

References 36 publications

Croton urucurana Baill. Ameliorates Metabolic Associated Fatty Liver Disease in Rats

Croton urucurana Baill. Ameliorates Metabolic Associated Fatty Liver Disease in Rats

Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases

Cornus iridoid glycoside alleviates sepsis-induced acute lung injury by regulating NF-κB and Nrf2/HO-1 pathways

Contact Info

Product

Resources

About