Protective effects of loquat (Eriobotrya japonica) leaves against ethanol-induced toxicity in HepG2 cells transfected with CYP2E1

Bae, Donghyuck; You, Yanghee; Yoon, Ho‐Geun; Kim, Kyungmi; Lee, Yoo‐Hyun; Kim, Yong-Jae; Baek, Hum-Young; Kim, Sunoh; Lee, Jeongmin; Jun, Woojin

doi:10.1007/s10068-010-0154-3

Cited by 25 publications

(23 citation statements)

References 14 publications

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“…By using different cell models, different loquat fruit and leaf extracts showed protective effects against intracellular reactive oxygen species (ROS) [46,62,63]. Loquat fruit extract significantly inhibited the formation of ROS and NO in leukocytes and erythrocytes induced by the antibiotic chloramphenicol [63].…”

Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

“…Loquat fruit extract significantly inhibited the formation of ROS and NO in leukocytes and erythrocytes induced by the antibiotic chloramphenicol [63]. Ethanol extracts of loquat leaf showed hepatoprotective effects against ethanol-induced toxicity in HepG2 cells and a decrease in intracellular ROS formation, and increase in hepatic antioxidant activity, as well as increased cellular viability were observed [62]. Loquat leaf extract significantly increased antioxidant enzyme activities of SOD, catalase, glutathione- S -transferase, glutathione peroxidase, glutathione reductase, reduced glutathione in HepG2 cells [62].…”

Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

“…Ethanol extracts of loquat leaf showed hepatoprotective effects against ethanol-induced toxicity in HepG2 cells and a decrease in intracellular ROS formation, and increase in hepatic antioxidant activity, as well as increased cellular viability were observed [62]. Loquat leaf extract significantly increased antioxidant enzyme activities of SOD, catalase, glutathione- S -transferase, glutathione peroxidase, glutathione reductase, reduced glutathione in HepG2 cells [62]. In another cell model using β-amyloid-induced oxidative stress in neuronal PC12 cells, treatment of loquat leaf efficiently suppressed the formation of intracellular ROS formation by Aβ 1-42 peptide and inhibited neuronal cell death [46].…”

Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

“…Long-term heavy consumption of alcohol may result in the development of alcohol related liver disease, where the induction of cytochrome P-450 2E1 (CYP2E1) by ethanol could result in a state of oxidative stress. Loquat leaf extracts showed hepatoprotective effects in HepG2 cells overexpressing CYP2E1 by improving the hepatic antioxidant activity and decreasing the formation of intracellular ROS [62]. As a result, loquat leaf extract increased HepG2 cell viability in a concentration-dependent manner and showed protective activity against ethanol-induced toxicity in HepG2 cells [62].…”

Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

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Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Liu

Zhang

et al. 2016

IJMS

127

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Loquat (Eriobotrya japonica Lindl.) is a subtropical fruit tree with high medicinal value native to China. Different organs of loquat have been used historically as folk medicines and this has been recorded in Chinese history for thousands of years. Research shows that loquat extracts contain many antioxidants, and different extracts exhibit bioactivity capable of counteracting inflammation, diabetes, cancer, bacterial infection, aging, pain, allergy and other health issues. Bioactive compounds such as phenolics and terpenoids have been isolated and characterized to provide a better understanding of the chemical mechanisms underlying the biological activities of loquat extracts. As the identification of compounds progresses, studies investigating the in vivo metabolism, bioavailability, and structure–activity relationships, as well as potential toxicity of loquat extracts in animal or cell models are receiving more attention. In addition, genetic studies and breeding of loquat germplasms for high contents of health-benefiting compounds may provide new insight for the loquat industry and research. This review is focused on the main medicinal properties reported and the possible pharmaceutically active compounds identified in different loquat extracts.

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Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

Section: Bioactivities Of Loquat Extractsmentioning

confidence: 99%

See 2 more Smart Citations

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Liu

Zhang

et al. 2016

IJMS

127

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“…Especially, various triterpenes, sesquiterpenes, flavonoids and tannins have been found in the Eriobotryae folium. Moreover extract and isolated compound from leaves of this plant have been reported to be physiological active, exhibiting antioxidant, anti-inflammatory, antitumor, hypoglycemic effect, liver protective effect and antimutagenic (Banno et al, 2005;Bae et al, 2010;Cha et al, 2011aCha et al, , 2011bChoi et al, 2011). Moreover, antifibrosis effects of triterpene acids of Eriobotryae folium has been reported (Yang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin E₂Up-regulation and Wound Healing Effect of the Ethanol Extract of Eriobotryae Folium in Human Keratinocyte

Im¹,

Lee²

2014

Korean Journal of Medicinal Crop Science

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: Prostaglandin (PG) E 2 is an important mediator of skin wound healing without excessive scarring and gastric ulcer healing. However, PGE 2 has a short lifetime in vivo because it is metabolized rapidly by 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Ethanol extract of Eriobotryae folium (EFEE) elevated intracellular and extracellular PGE 2 levels in HaCaT cells and inhibited 15-PGDH (ED 50 : 168.4 ㎍/mL) with relatively low cytotoxicity (IC 50 : 250.0 ㎍/mL). Real-time PCR analysis showed that mRNA expression of cyclooxygenase (COX)-1 and COX-2 enzymes were increased and prostaglandin transporter (PGT) was decreased in HaCaT cells by EFEE. Moreover, wound healing effect of EFEE (168.4 ㎍/mL) was comparable to that of TGF-β1 (300 pg/mL) as a positive control. These results demonstrate that EFEE may be valuable therapeutic materials for the treatment of PGE 2 level dependent diseases.

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Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats

Chiang

Badrealam

Shibu

et al. 2018

Environmental Toxicology

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Eriobotrya japonica (EJ) is a traditional Chinese plant with high medicinal value. EJ extracts are reported to exhibit antioxidant and anti-inflammatory biological attributes. The current study aims to evaluate the prospective efficacy of E. japonica leave extract (EJLE) against Angiotensin-II induced cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats (SHRs). For the in vitro studies, Angiotensin-II pretreated H9c2 cells were treated with EJLE and analyzed through Western blotting and rhodamine phalloidin staining for their cardio-protective attributes. In the in vivo studies, 12-week-old SHRs were randomly divided into groups: SHRs supplemented with EJLE, control SHR group supplemented with PBS; in addition, a control group of Wistar-Kyoto rats (WKY) was also employed. All rats were supplemented twice a week for 8 week time interval. Finally, echocardiography, morphological, histology, and Western blot analysis were performed to assess their role against cardiac hypertrophy. Interestingly, we could observe that supplementation of EJLE could rescue Ang-II induced cardiac hypertrophy as evident through Western blot, rhodamine phalloidin staining, and Hematoxylin-Eosin staining. Notably, morphological and echocardiography data provided further supports for their ability to ameliorate cardiac characteristics. Cumulatively, the results clearly suggests that supplementation of EJLE promotes cardio-protective effects through amelioration of cardiac hypertrophy in vitro and in vivo.

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Protective effects of loquat (Eriobotrya japonica) leaves against ethanol-induced toxicity in HepG2 cells transfected with CYP2E1

Cited by 25 publications

References 14 publications

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Prostaglandin E₂Up-regulation and Wound Healing Effect of the Ethanol Extract of Eriobotryae Folium in Human Keratinocyte

Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats

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Protective effects of loquat (Eriobotrya japonica) leaves against ethanol-induced toxicity in HepG2 cells transfected with CYP2E1

Cited by 25 publications

References 14 publications

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Prostaglandin E2Up-regulation and Wound Healing Effect of the Ethanol Extract of Eriobotryae Folium in Human Keratinocyte

Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats

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Product

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Prostaglandin E₂Up-regulation and Wound Healing Effect of the Ethanol Extract of Eriobotryae Folium in Human Keratinocyte