Protective effects of manganese(II) chloride on hyaluronan degradation by oxidative system ascorbate plus cupric chloride

Abstract

The degradation of several high-molar-mass hyaluronan samples was investigated in the presence of ascorbic acid itself and further by an oxidative system composed of ascorbic acid plus transition metal ions, i.e. Fe(II) or Cu(II) ions. The latter oxidative system imitates conditions in a joint synovial fluid during early phase of acute joint inflammation and can be used as a model for monitoring oxidative degradation of hyaluronan under pathophysiological conditions. The system Cu(II) plus ascorbate (the Weissberger oxidative system) resulted in a more significant decrease of hyaluronan molar mass compared to the oxidative system Fe(II) plus ascorbate. Addition of manganese(II) chloride was found to decrease the rate of the oxidative damage of hyaluronan initiated by ascorbate itself and by the Weissberger system.

Protective effect of manganese in cadmium-induced hepatic oxidative damage, changes in cadmium distribution and trace elements level in mice

“…However, at low doses manganese, differently from transition metals such as iron and copper, was found to act as a potent antioxidant in the protection against oxidative stress (Sziraki et al ., 1995). In vitro experiments revealed the ability of Mn(II) to scavenge oxygen free radicals generated in differently mediated lipid peroxidation conditions (Cavallini et al ., 1983 ; Coassin et al ., 1992 ; Sziráki et al ., 1999 ; Hussain & Ali, 1999 ; Valachová et al ., 2010 ).…”

The promising performance of manganese gluconate as a liquid redox sulfur recovery agent against oxidative degradation

“…As Figure 6 demonstrates, in contrast to the system investigated by Cheton and Archibald [ 12 ] and by Valachova et.al. [ 11 ], manganese brought about a higher gluconate degradation rate than copper and iron. Within 100 h of reaction, gluconates that had been degraded by manganese, copper, and iron were ca 20%, 9%, and 7% respectively.…”

“…Valachova et al. reported that the addition of manganese inhibited the degradation of hyaluronan samples by the ascorbic Fenton catalyzed by iron or copper [ 11 ]. The inhibition has been attributed to the ability of manganese (II) to act as hydroxyl free radicals scavenger.…”

Citrate Functionalized Mn3O4in Nanotherapy of Hepatic Fibrosis by Oral Administration

“…First, redox reaction between the Mn(II) and Mn(III) states in C-Mn 3 O 4 NPs due to ligand to metal charge transfer may help it to act as a scavenger of hydroxyl and superoxide radicals (details are discussed in previous section of the text). Second, it may act as a chain-breaker in inhibiting iron-induced lipid peroxidation chain reactions [59,60], and as proposed in other studies, Mn(II) may scavenge peroxyl lipid radicals via the following reaction [61,62]: …”