Protective effects of maslinic acid against alcohol-induced acute liver injury in mice

Yan, Sheng; Yang, Hui; Lee, Hsiang Lin; Yin, Mei

doi:10.1016/j.fct.2014.09.018

Cited by 56 publications

(27 citation statements)

References 36 publications

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“…Numerous studies have demonstrated the association of alcohol-induced hepatotoxicity with oxidative stress and lipid peroxidation [21,22]. Lipid peroxidation Figure 6.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice

et al. 2016

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“…Numerous studies have demonstrated the association of alcohol-induced hepatotoxicity with oxidative stress and lipid peroxidation [21,22]. Lipid peroxidation Figure 6.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice

et al. 2016

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“…TNF-α and IL-6 are widely considered to be the most critical inflammatory cytokines in alcohol-induced liver damage [21]. Oxidative stress and inflammation are closely interrelated in alcohol-induced liver damage as inflammatory cytokines promote ROS generation and vice versa, and mitochondrial GSH depletion enhances liver sensitization to alcohol through TNF-α medicated hepatocellular death [22][23][24]. Based on the present evaluation, KPF markedly reduces hepatic production of both oxidative and inflammatory factors in alcohol-exposed mice.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Hepatoprotective Effects of a Peptide Fraction from Krill Protein Hydrolysates against Alcohol-Induced Oxidative Damage

et al. 2019

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Background: Krill (Euphausia superba) represent the largest animal biomass on earth, and are a rich source of high-quality protein with essential amino acids. Krill-derived peptides are renowned for their antioxidant activities. Hence, these peptides may have protective effects against oxidative stress. Alcoholic liver disease is a prevalent cause of death worldwide. The present study explores the hepatoprotective effects of krill peptide hydrolysate fractions against ethanol-induced liver damage in BALB/c mice. Methods: Hydrolysis was carried out by mimicking the gastrointestinal digestion environment and the filtrate was fractionated based on molecular weight (<1 kDa, 1–3 kDa, and >3 kDa). The 1–3 kDa fraction (KPF), which indicated the highest antioxidant effect, was further investigated for its effect on weight and survival rate increase in mice and its influence on serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and liver cholesterol levels. Moreover, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels were measured, followed by Nrf2 and HO-1 expression. Histopathology studies were conducted to assess hepatic tissue damage. Results: KPF enhanced the weight and survival rate of mice while reducing serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and liver cholesterol levels. Moreover, KPF upregulated SOD, CAT, and GPx in liver tissues, while downregulating tumor necrosis factor α and interleukin-6 mRNA expression. KPF further increased Nrf2 and HO-1 expression and suppressed ethanol-induced apoptotic proteins in the liver. Histopathology of KPF-treated mice showed less hepatic tissue damage compared to ethanol-treated mice. Conclusions: Hydrolysates and bioactive peptides prepared from krill can be employed as functional foods to enhance liver function and health. Further investigations of KPF could lead to the development of functional foods.

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“…The development of clinical therapy of alcoholic liver disease has received global attention since abstinence seems to be the only effective means to control alcoholic liver disease . As the link between oxidative stress and liver damage was established via the studies in experimental alcoholic liver disease, testing of antioxidant activity against ethanol‐induced liver injury has included many compounds such as garlic oil, wolfberry, green tea, silymarin and maslinic acid . However, these treatments are not widely accepted due to their limited regional availability, and more importantly, because of their disagreeable sensory properties.…”

Section: Discussionmentioning

confidence: 99%

“…23 As the link between oxidative stress and liver damage was established via the studies in experimental alcoholic liver disease, 24 testing of antioxidant activity against ethanol-induced liver injury has included many compounds such as garlic oil, 25 wolfberry, 26 green tea, 27 silymarin 28 and maslinic acid. 29 However, these treatments are not widely accepted due to their limited regional availability, and more importantly, because of their disagreeable sensory properties. Metabolism of ethanol is really complex and involves oxidative and non-oxidative pathways.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of Lactococcus lactis expressing alcohol dehydrogenase and acetaldehyde dehydrogenase on acute alcoholic liver injury in mice

Lyu

Zhong

Liu

et al. 2018

J of Chemical Tech & Biotech

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BACKGROUND Alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) play important roles in alcohol metabolism. Therefore, a possible effective way to attenuate alcoholic liver damage is the exogenous supply of these two enzymes to the stomach as they might accelerate the oxidation of ethanol into nontoxic acetate. RESULTS ADH and ALDH were coexpressed in Lactococcus lactis NZ3900 and used as treatments for acute alcoholic liver injury in mice. Intragastric ethanol administration was carried out at 5.6 g kg‐1 body weight per day in mice for 15 consecutive days and different doses of recombinant ADH‐ALDH L. lactis treatment were administrated together with ethanol. A high dose of L. lactis recombinant ADH‐ALDH treatment (ADH activity of 2000 U kg‐1 BW and ALDH activity of 1000 U kg‐1 BW) reduced the serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels by 38.1%, 54.8% and 23.2%, respectively, in ethanol‐treated mice. Moreover, it also helped maintaining serum lipid levels and liver oxidative stress parameters against ethanol. Histopathological examination of mice livers revealed that L. lactis recombinant ADH‐ALDH at a high dose (ADH activity of 2000 U kg‐1 BW and ALDH activity of 1000 U kg‐1 BW) protected liver tissue from the damage induced by ethanol. CONCLUSION Results demonstrate that L. lactis with ADH and ALDH activity exhibit a dose‐dependent protective effect on alcohol‐induced liver damage in mice. © 2017 Society of Chemical Industry

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Protective effects of maslinic acid against alcohol-induced acute liver injury in mice

Cited by 56 publications

References 36 publications

Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice

Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice

In Vivo Hepatoprotective Effects of a Peptide Fraction from Krill Protein Hydrolysates against Alcohol-Induced Oxidative Damage

Protective effects of Lactococcus lactis expressing alcohol dehydrogenase and acetaldehyde dehydrogenase on acute alcoholic liver injury in mice

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