Protective Effects of Montelukast and L-Carnitine on Cyclophosphamide-Induced Lung Injury

Abstract

The major aim of this work was to study the protective effects of the cysteinyl-leukotriene antagonist montelukast (ML) and L-Carnitine (LC) against cyclophosphamide (CP)-induced pulmonary injury in experimental rats. Thirty adult male albino rats were categorized at random into five groups of 6 rats each. The first group served as normal control group. All other groups were injected once with CP (150 mg/kg, i.p.). The second group was kept as CP toxicity control group The third group was injected with ML (10 mg/kg/day, i.

Therapeutic effects of Laser and L-carnitine against amiodarone-induced pulmonary toxicity in adult male rats

“…In this study, LC significantly increased the levels of GSH, GST, SOD and NO. This is in agreement with a previous report on the antioxidant and free radical-scavenging properties of LC [19]. It has been suggested that LC is involved in ATP synthesis through its role in mobilization of mitochondrial fatty acids during β-oxidation.…”

Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.

“…Metabolism of CPA by enzyme system (hepatic cytochrome P-450) results in production of 2 metabolites that are phosphoramide mustard and acrolein [32] . The phosphoramide mustard has cytotoxic effect on the tumour cells and acrolein has a cytotoxic effect on normal cells [33] .…”

“…Also, CAR plays an important protective role against titanium dioxide nanoparticles induced -cardiac toxicity [14] . L-carnitine has antioxidant effect by multiple mechanisms as a free radical scavenger, its ability of reduction of the formation of ROS and its antiinflammatory activity [32] , but there is contraverse about the potency of the protective effect of LC. some studies reported that it can minimize the nephrotoxic effect of gentamicin [22] while other studies postulated that LC did not prevent the cisplatin nephrotoxicity [26] .…”

The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity

“…In addition, carnitine deficiency can aggravate cardiotoxicity and it is important to monitor serum and urinary carnitine levels [30]. Carnitine supplementation showed beneficial effects in various cyclophosphamide-induced toxicities [31][32][33][34]. Cyclophosphamide administration affects the ability of the heart mitochondria to retain accumulated calcium [35].…”