Curcumin (CMN) has been well studied due to its economic and medical importance. Traditional Egyptian Medicine claims the use of its powder against biliary disorders, anorexia, coryza, cough, diabetic wounds, hepatic disorder, rheumatism and sinusitis. The current study was designed to examine the possible beneficial effect of CMN in preventing the acute renal failure and related oxidative stress caused by chronic administration of cyclosporine (CsA) in rats. The study included two experiments, the first one was carried out to follow up the changes that could occur in kidney function as a result of cyclosporine (CsA) administration. Cyclosporine administration exerted significant (P< 0.01) elevation of serum urea, creatinine, potassium (K), parathormone (PTH), malondialdehyde (MDA) and asymmetrical dimethylarginine (ADMA). Meanwhile, cyclosporine treatment exerted significant (P< 0.01) decline in the level of serum sodium (Na) and total nitric oxide (NO), the content of kidney reduced glutathione (GSH) and the activities of glutathione peroxidase (G px), catalase (CAT) and superoxide dismutase (SOD) as compared with their corresponding normal rats. In the second experiment, the nephritic rats were treated with curcumin and remarkable corrections were occurred in all previous parameters. Thus, the current investigation was designed to examine the possible beneficial effect of CMN in preventing the renal failure and related oxidative stress caused by administration of CsA in rats.

The use of Nanoparticles (NPs) and nanostructured materials (NSMs) consider a new light in the progress of disease-modifying treatments for many pathological disorders. The present study is an attempt to investigate the curative effect of Nanocurcumin against long-term MSGadministration on rat liver. A total of 40 adult male Wistar albino rats were divided into the following groups: Control group (C) of 14 rats given saline; Nanocurcumin (Nano-Cur) control group of 14 rats inoculated orally with Nano-Cur (100mg/Kg b.wt/day)for 8 weeks; Monosodium group received MSG 10 mg/kg /b. w. for eight weeks; the therapeutic group was first given MSG alone for 4 weeks and was secondly administered Nano-Cur for 4 weeks. At the end of 8 weeks, animals were sacrificed by ether inhalation anesthesia where blood and liver tissues were collected to study biochemical parameters.MSG administration exerted significant elevation of cholesterol, TG, HDL, LDL, VLDL and MDA. Also showed an increase in liver enzymes. On the other hand, in the therapeutic group, Nano-Cur showed significant improvement in the previous parameters.

Purpose: To compare the effects of laser and/or L-carnitine (LC) on amiodarone (AM)-induced lung toxicity in adult male rats. Methods: Lung toxicity was induced in 50 healthy male albino rats (150-180 g) by AM for 8 weeks. The rats were divided into 4 groups (7 per group): AM recovery, LC, laser, and laser + LC. After a 4-week exposure to laser and/or LC, key antioxidant enzymes, nitric oxide (NO), angiotensin II, cyclooxygenase-II (COX-II) and lipoxygenase (LOX) as well as oxidative stress and inflammation parameters were determined. Results: Administration of LC and/or laser exposure led to significant increases in reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and angiotensin II; and significant decreases in nitric oxide (NO) level and glutathione-S-transferase (GST) activity in the AM

The present study was designed to investigate the effect of rutin on over dose acetaminophen-induced hepatotoxicity with overdose in rats. Adult male albino rats were divided into four groups. Group 1 served as control and group2: rats received rutin .Hepatotoxicity where received induced in groups 3&4,where group 3 rats were given acetaminophen (750mg/kg b.w) every 72h over a period of 21 days then left for 30 days without any treatment .Group 4: rats receiving dose of acetaminophen for 21 days (750mg/kg b.w) every 72 h then treated orally with rutin 25mg/kg b.w daily for 30 day. A significant increase in the activities of liver markers enzymes, serum aminotransferase, γ-glutamyl transpeptidase , lipid peroxidation (MDA) and lipid profile and a decrease in the activities of superoxide dismutase(SOD).Rutin supplementation after acetaminophen treatment significantly decreased the levels of liver markers enzymes, lipid profile was observed and MDA while, significant elevated in the activity of liver SOD was recorded when compared with control group .