Role of Rutin on Acetaminophine Induced Hepatotoxicity in Adult Male Rats

Abstract

The present study was designed to investigate the effect of rutin on over dose acetaminophen-induced hepatotoxicity with overdose in rats. Adult male albino rats were divided into four groups. Group 1 served as control and group2: rats received rutin .Hepatotoxicity where received induced in groups 3&4,where group 3 rats were given acetaminophen (750mg/kg b.w) every 72h over a period of 21 days then left for 30 days without any treatment .Group 4: rats receiving dose of acetaminophen for 21 days (750mg/kg b.w) every 72 h then treated orally with rutin 25mg/kg b.w daily for 30 day. A significant increase in the activities of liver markers enzymes, serum aminotransferase, γ-glutamyl transpeptidase , lipid peroxidation (MDA) and lipid profile and a decrease in the activities of superoxide dismutase(SOD).Rutin supplementation after acetaminophen treatment significantly decreased the levels of liver markers enzymes, lipid profile was observed and MDA while, significant elevated in the activity of liver SOD was recorded when compared with control group .

Potential protective role of spirulina algae and/or aminoguanidine on carbon tetrachloride induced liver fibrosis in rats.

“…The liver is a vital organ admitted in more than five hundred metabolic responses within the biological system and one of its major capacities is the detoxification of injurious substances or poison. However, it can be damaged by toxicants, which within the process may mutilate the metabolic actions of the liver, thus giving rise to liver injury [1,2]. Liver fibrosis is attached to inflammation, tissue remodeling under wound healing and excessive accumulation of extracellular matrix [3].…”