Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats

Yaman, Ihsan; Balikci, Engin

doi:10.1016/j.etp.2009.03.006

Cited by 180 publications

(121 citation statements)

References 35 publications

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“…Several pharmacological effects, e.g., antibacterial, antiparasitic and antiinflammatory effects have been attributed to NS or its active compounds which include thymoquinone, thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellicine, nigellimine-N-oxide, nigellidine and alpha-hedrin (Randhawa and Al-Ghamdi, 2002). Thymoquinone is reported to prevent oxidative injury in various in vitro and in vivo studies in rats (Daba and Abdel-Rahman, 1998;Mansour et al, 2001;Yaman and Balikci, 2010). Thymoquinone has been suggested to act as an antioxidant and was reported to prevent membrane lipid peroxidation in tissues (Mansour et al, 2002).…”

mentioning

confidence: 99%

Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Yaman¹,

Durmuş²,

Çeribaşi³

et al. 2010

Vet. Med.

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This experiment was conducted in order to compare the effects of Nigella sativa (NS) and silver sulfadiazine (SSD) cream on healing of burn wounds in rats. Fifty four adult, male Wistar-albino rats were divided into three groups of equal numbers. A burn was generated on the backs of all the rats. The burned areas in the first, second and third groups were covered with daily cold cream (control), SSD cream and NS cream (50% NS oil + 50% cold cream), respectively. Four, nine, and 14 days later, the rats were sacrificed and the burned skin tissue samples were collected for histopathological examinations. Histopatological evaluations on the 4 th , 9 th and 14 th days showed burn healing to be better in the NS and SSD groups with respect to the control group. Wound healing was significantly different among the groups at 4 th , 9 th and 14 th days (P < 0.001). In conclusion, application of NS and SSD cream are effective in healing burn related skin wounds in the rat model.

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mentioning

confidence: 99%

Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Yaman¹,

Durmuş²,

Çeribaşi³

et al. 2010

Vet. Med.

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“…Sahin et al (2001) investigated the protective effect of vitamin E against heat stress-induced lipid peroxidation, and they reported a similar result. TQ has been reported to prevent oxidative injuries across several in vitro and in vivo studies (Daba and AbdelRahman, 1998;Mansour et al, 2001;Yaman and Balikci, 2010), and these results may be ascribed to its ability to scavenge free radicals. The negative effect of heat stress was further demonstrated by the histopathological and ultrastructural changes that were observed in liver and kidney tissues.…”

Section: Discussionmentioning

confidence: 89%

Effects of vitamin E and thymoquinone on physiological and histological characteristics of heat-stressed male mice

Alzahrani¹

2011

Afr. J. Pharm. Pharmacol.

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Previous studies have shown that heat stress can lead to tissue damage and multiple organ dysfunctions. The present study elucidates the negative effects of heat stress and the possible protective effects of vitamin E or thymoquinone against the physiological and histological consequences of heat stress. Forty male mice were distributed into four groups as follows: group I was a control group that was orally supplemented with distilled water; group II was subjected to heat stress (HS) (at a humidity of 50 to 55% and a temperature of 42°C) for 75 days; group III was subjected to heat stress and was orally supplemented with vitamin E (20 IU/kg body weight/day for 75 days); and group IV was subjected to heat stress and was orally supplemented with thymoquinone (TQ) (5 mg/kg body weight/day for 75 days). We found that the leucocyte count, Hb, and alanine aminotransferase (ALT) were significantly decreased in the HS-treated group. In contrast, the free radical (FR) levels were significantly elevated. Moreover, histopathological and ultrastructural studies of the HS-treated group revealed dilatation of the hepatic sinusoids, interstitial hemorrhage, hepatocytes that were infiltrated with fat droplets in the liver, hemorrhage enlargement of the mitochondria and dilatation of the renal tubules. Notably, supplementation with either TQ or vitamin E completely reversed the biochemical, histopathological and ultrastructural changes that were induced by heat stress yielding levels that were similar to the control values. Taken together, our data revealed the benefits of vitamin E or TQ supplementation as a means to ameliorate the negative effects of heat stress.

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“…NS was reported to have a preventive effect on oxidative stress by causing to rise of antioxidant enzymes (Khattab & Nagi 2007;Yaman & Balikci 2010). The antioxidant activity of NS seeds and oil was basically dependent on its active constituent thymoquinone and carvacrol (Thippeswamy & Naidu 2005).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial, anti-inflammatory and antioxidant activity ofNigella sativain clinically endometritic cows

Yıldız

Balikci

2015

Journal of Applied Animal Research

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The aim of this study was to investigate the response to intrauterine infusion of Nigella sativa (NS) and ceftiofur and to evaluate the possible antimicrobial, antioxidant and anti-inflammatory effects of NS in clinically endometritic cows. A total of 30 clinically endometritic cows (10 cows in each group) were randomly divided into 3 treatment groups: an i.u. infusion of 100 mL of methanol extract of NS was given once a day during 3 days in group NS; an i.u. infusion of a 20-mL suspension (Excenel®, Pfizer) containing 1 g of ceftiofur as ceftiofur hydrochloride was given once a day during three days in group CH; cows with no treatment belonged to group C. After the treatment, there were slight vaginal discharges in 3/10 animals in group NS and 2/10 animals in group CH. GSH-Px and superoxide dismutase levels increased and malondialdehyde concentration decreased significantly (P < .05) in groups NS and CH after treatment when compared to pretreatment ones. Hp and SAA levels of groups NS and CH decreased significantly (P < .05) after treatment when compared to group C. NS had antimicrobial, antioxidant and antiinflamatory effects in clinical endometric cows. Although the antimicrobial effect of NS was less than that of CH, this study indicates a therapeutic value of NS in clinically endometritic cows. NS might be a promising therapy for cows with clinical endometritis in the future. ARTICLE HISTORY

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Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats

Cited by 180 publications

References 35 publications

Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Effects of vitamin E and thymoquinone on physiological and histological characteristics of heat-stressed male mice

Antimicrobial, anti-inflammatory and antioxidant activity ofNigella sativain clinically endometritic cows

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