Antimicrobial, anti-inflammatory and antioxidant activity of<i>Nigella sativa</i>in clinically endometritic cows

Yıldız, Atilla; Balikci, Engin

doi:10.1080/09712119.2015.1091341

Cited by 6 publications

(9 citation statements)

References 29 publications

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“…Our results demonstrated significant alterations in renal apoptotic cells, oxidative stress markers, and two important inflammatory mediators, MCP‐1 and TNF‐α, after 2 weeks of ureteral obstruction. It has been shown that NS and TQ, the most important active constituent of NS oil, have notable anti‐inflammatory and antioxidant effects in different tissues (Hosseinian et al, ; Inci et al, ; Mohebbati et al, ; Yildiz & Balikci, ) and act as potent apoptosis modulator (Li, Rajendran, & Sethi, ; Majdalawieh & Fayyad, ). Present results have shown that improvement of inflammation, oxidative stress, and apoptosis in kidneys from NS‐treated rats were accompanied by marked decrease in renal Ang II expression, which might be due to direct or indirect RAS inhibition by NS extract.…”

Section: Discussionmentioning

confidence: 99%

Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction

Hosseinian

Ebrahimzadeh‐Bideskan

Shafei

et al. 2018

Phytotherapy Research

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Unilateral ureteral obstruction (UUO) is a well-established experimental model to evaluate renal interstitial fibrosis. Current study is aimed to investigate the effects of Nigella sativa (NS) extract and renin-angiotensin system (RAS) blockade against kidney damage following UUO in rats. In this study, the rats received intraperitoneal injection of losartan (15 mg/kg), captopril (30 mg/kg), and two doses of NS extract (200 and 400 mg/kg) for 18 consecutive days. At the fourth day of the experiment, laparotomy was performed, and the left ureter was ligated. Sham-operated animals received saline as vehicle, and laparotomy without ureteral ligation was done. UUO was associated with significant increase in the expression of renal angiotensin II and monocyte chemoattractant protein-1, concentration of malondialdehyde and tumor necrosis factor-α, and the number of apoptotic cells when compared with sham group. Renal total thiol content and the activity of antioxidant enzymes were significantly reduced as compared with the sham group. However, treatment of obstructed rats with losartan, captopril, and NS extract significantly improved these renal impairments when compared with UUO group. Thus, NS extract, a potent antioxidant and anti-inflammatory herb, is a therapeutic agent to treat the UUO-induced kidney damage comparable with the well-known RAS inhibitors captopril and losartan.

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Section: Discussionmentioning

confidence: 99%

Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction

Hosseinian

Ebrahimzadeh‐Bideskan

Shafei

et al. 2018

Phytotherapy Research

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“…It is established in many studies that immunosuppression which earlier required for maintaining pregnancy might be the cause of retained fetal membranes after calving thereby urging the need of immunomodulatory agents in order to maintain healthy reproductive environment of the body. Besides the immunomodulatory properties of polyherbal preparation, the antimicrobial and anti-inflammatory properties of herbs such as Nigella sativa (Yildiz and Balikci, 2016), Rubia cordifolia (Tailor et al, 2010), Tinospora cordifolia (Jeyachandran et al, 2003) provide more favorable environment and reduced pathogen invasion in reproductive tract of cows resulting in less number of cases of metritis and infections. This nutritional strategy post-partum could some extend replace the antibiotic therapy in producing animals.…”

Section: Reproductive Performancementioning

confidence: 99%

Effect of Fat and Protein Along with Polyherbal Preparation on Reproductive Health of Periparturient Karan Fries Cows

Sharma¹,

Kundu²,

Tariq³

et al. 2021

IJAR

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Background: The term “transition” comprises the various important physiological, metabolic and nutritional changes in the productive cycle of the cattle. It influences lactation, nutritional status, postpartum diseases and reproductive performance of the animal. It is, therefore, important to elaborate various nutritional strategies in this phase for optimizing productivity and minimizing health problems. A preliminary study was conducted to evaluate the influence of fat and protein along with indigenous traditional knowledge-based polyherbal preparation supplementation on reproductive and immune parameters of periparturient crossbred cows. Methods: Twenty-seven pregnant Karan Fries cows, in their last trimester were selected and divided into 3 treatment groups (T1, T2 and T3) consisting of nine animals each, based on most probable production ability (MPPA; 3002 kg) and body weight (423 kg). Cows of groups T1 (control), T2 and T3 were given TMRs having 13.1, 13.1, 16.1% crude protein (CP) and 9.82, 9.82, 10.8 MJ/kg metabolizable energy (ME) respectively, during pre-partum period. Whereas, during post-partum period, cows were offered TMRs containing 14.0, 16.8, 16.8% CP and 10.2, 11.0, 11.0 (MJ/kg) ME, respectively. T2 and T3 groups were also supplemented with polyherbal preparation post-partum. Result: The results revealed that cows in T2 and T3 group had lower incidence of retained placenta, cervicitis, metritis and better conception rate than cows of control group. Also, dietary treatments facilitated early involution of pre gravid uterine horn (P less than 0.05). Plasma total immunoglobulins (mg/ml) concentration was found to be significantly (P less than 0.05) higher in T3 group followed by T2 group. Hence, it was concluded that increasing energy and protein levels along with polyherbal mixture supplementation during transition period reduced periparturient stress and improved reproductive performance of dairy cows.

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“…The present study also shows that administration of N. sativa oil significantly decreased the amount of inflammatory infiltration. A large body of experimental research has confirmed the anti-inflammatory activity of N. sativa (Ahmad et al, 2013;Yildiz and Balikci, 2016;Rahmani and Aly, 2015). This anti-inflammatory effect may be appropriate to inhibit the release of mediators by thymoquinone and other constituents of N. sativa which have anti-inflammatory,…”

Section: Effect Of Nigella Sativa Oil On Oral Mucositis In Ratsmentioning

confidence: 85%

“…One possible mechanism by which N. sativa exerts its anti-inflammatory effect is through the inhibition of both cyclooxygenase and lipoxygenase pathways (Ali and Blunden, 2003). Also, the anti-inflammatory and antioxidant effects of N. sativa oil can enhance its phagocytic activity; thus, it can play a significant therapeutic role in fighting against the microorganisms (Yildiz and Balikci, 2016). The anti-inflammatory and antioxidant effects of N. sativa oil have been found to be higher than those of thymoquinone, which is known to be the active component of N. sativa oil (Ali and Blunden, 2003).…”

Section: Effect Of Nigella Sativa Oil On Oral Mucositis In Ratsmentioning

confidence: 99%

Effect of intraperitoneal injection of Nigella sativa oil on 5-fluorouracil-induced oral mucositis in rats

Kazemi,

Akbar Moghadamnia,

Saebnouri

et al. 2022

JBS

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Although many studies have shown that administration of Nigella sativa oil can decrease inflammation and facilitate tissue regeneration, the efficacy of its systemic administration for treatment of chemotherapy-induced oral mucositis has not been investigated. This study aimed to assess the effect of intraperitoneal injection of N. sativa oil on 5-fluorouracil (5-FU)-induced oral mucositis in rats. This study evaluated 72 healthy Wistar rats, weighing 250-300 g. The rats were randomly divided into three groups of control, placebo, and treatment (n=24). The rats received intraperitoneal injection of 5-FU on days 1 and 3. The rats’ cheek mucosa was then wounded with a linear scratch by an 18-gauge needle on day 3. The placebo and N. sativa oil were administered in groups B and C, respectively during the study period. Histological changes in oral mucosa were assessed on days 4, 6, and 8. Data were statistically analyzed using SPSS via the ANOVA, and the Kruskal-Wallis test, followed by the Mann Whitney multiple comparisons test. The mucositis score and inflammation score significantly decreased in the treatment group compared with the control and placebo groups (P<0.05). But there was no significant different between the groups regarding the connective tissue changes (P>0.05). Our findings suggest that N. sativa oil can have a notable efficacy for improvement of oral mucositis and can decrease the inflammation score in rats undergoing chemotherapy. Our results suggest that Nigella sativa can be used as a valuable remedial agent and can be a possible candidate for treatment of chemotherapy-induced oral mucositis.

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Antimicrobial, anti-inflammatory and antioxidant activity ofNigella sativain clinically endometritic cows

Cited by 6 publications

References 29 publications

Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction

Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction

Effect of Fat and Protein Along with Polyherbal Preparation on Reproductive Health of Periparturient Karan Fries Cows

Effect of intraperitoneal injection of Nigella sativa oil on 5-fluorouracil-induced oral mucositis in rats

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