Protective Effects of Proanthocyanidin on Cerulein-induced Acute Pancreatic Inflammation in Rats

Abstract

Background: The aim of this study was to assess the possible protective effect of proanthocyanidin against cerulein-induced acute pancreatic inflammation (AP) and oxidative injury.

Protective Effects of Lycopene on Cerulein-Induced Experimental Acute Pancreatitis in Rats

“…[37]. In agreement with the previous studies [14,15], in the present study MDA levels, an index of lipid peroxidation, were significantly increased. Moreover, present results also demonstrated that lycopene pretreatment of the rats before pancreatitis induction caused significant reduction in MDA.…”

“…To induce acute pancreatitis, rats were administered four subcutaneous injections of 20 mg/kg body weight of cerulein (Sigma, St. Louis, MO) at hourly intervals within 4 h [14,15]. Lycopene was administered intraperitoneal (i.p.)…”

“…As free radical scavengers are shown to be protective in pancreatitis against oxidative tissue injury [2,4,13,14], the purpose of this study was to establish the putative protective effect of lycopene on cerulein-induced experimental acute edematous pancreatitis in rats using both histologic and biochemical parameters.…”

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

“…The release of free oxygen radicals may cause direct toxic effects on pancreatic acinar cell leading to its damage [34]. It is well known that antioxidants are potent scavengers of free oxygen radicals and serve as inhibitors of oxidative stress [1]. Melatonin (Mel), a multifunctional indolamine, is released from the pineal gland [20].…”

Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats

“…MPO is an essential enzyme for normal neutrophil function and is used as an index of tissue neutrophil infiltration because its levels increase when neutrophils are stimulated by various stimulants. [32,33] We observed that ALA administration reduced the MPO levels, suggesting a protective effect against free oxygen radical-induced damage through inhibition of neutrophil infiltration and activation in the pancreatic tissues.…”