Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice

Zhang, Xiping; Gao, Feng; Zhang, Jie; Cai, Yefeng; Tian, Hua; Zhang, Xiaofeng; Zhou, Yifeng; Wang, Zhiwei; Wang, Keyi

doi:10.1631/jzus.b0820179

Cited by 10 publications

(18 citation statements)

References 25 publications

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“…Sham-operateds were performed just by moving the pancreas and duodenum after opening the abdominal cavity. Fifteen minutes after successful operation, a single dose of Salvia miltiorrhizae injection (dosage 0.4 ml/100 g body weight [30][31][32]) was given via femoral vein to rats in the treated groups while equal volume of physiological saline solution was used in the sham-operated and model control group. Continuous infusion of physiological saline solution using a microinjection pump was then maintained until the end of the 3-, 6-and 12-h observation period in the corresponding groups.…”

Section: Preparation Of Animal Models and Associated Therapeutic Regimenmentioning

confidence: 99%

“…For rats in sham-operated groups, common bile duct was only dissociated but not ligated, and a layered suture of the abdominal wall was also performed to close the abdominal cavity. An intraperitoneal injection of Salvia miltiorrhizae injection at a dose of 0.2 ml/100g/day [30,33] was given to rats in the treated groups while equal volume of physiological saline solution was used in the sham-operateds and model control groups. Injection was maintained until the end of the 7-, 14-, 21-and 28-day observation period in the corresponding groups.…”

Section: Preparation Of Animal Models and Associated Therapeutic Regimenmentioning

confidence: 99%

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Effects of Salvia Miltiorrhizae on ICAM-1, TLR4, NF-κB and Bax Proteins Expression in Multiple Organs of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Zhang

Liang

et al. 2009

Inflammation

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To observe the protective effects of Salvia miltiorrhizae injection on multiple organs of rats with SAP or OJ. Two hundred eighty-eight rats were used for SAP-associated experiments and OJ-associated experiments. The rats were randomly divided into sham-operated, model control and treated group. According to the different time points after operation, the SAP rats in each group were subdivided into 3, 6 and 12 h groups while the OJ rats were divided into 7, 14, 21 and 28 days groups. The mortality rates, pathological changes and ICAM-1 (only in lung), TLR4 (only in liver), Bax and NF-kappaB proteins expression in multiple organs (liver, kidney, lung, intestinal mucosa, spleen, thymus and lymph nodes) were observed, respectively. The mortality rates of treated groups decreased in both SAP and OJ experiments. Compared to model control group, the pathological changes can be seen in treated groups including; (1) the pathological changes of multiple organs in SAP and OJ experiments were improved, the pathological severity scores of kidney (at 6 h), intestinal mucosa (at 12 h), spleen (at 6 and 12 h), thymus (at 3 and 6 h) and lymph nodes (at 3 and 6 h) in SAP experiment and of liver (on 21 and 28 days), lung (21 days), intestinal mucosa (on 21 and 28 days) and spleen (on 21 and 28 days) in OJ experiment significantly declined (P < 0.05 or P < 0.01); (2) the positive rate of Bax protein in pancreas (at 3 h) and liver (on 6 and 12 h) in SAP experiment and in liver (on 28 days), kidney (on 21 days), and thymus (on 28 days) in OJ experiment were significantly lower (P < 0.05 or P < 0.01); (3) the positive rate of NF-kappaB in liver (at 12 h) and kidney (at 6 h) in SAP experiment and in liver (on 21 days), kidney (on 28 days), intestinal mucosa (on 28 days) and thymus (on 14 days) in OJ experiment significantly decreased (P < 0.05). (4) the positive rate of ICAM-1 in lungs (at 12 h) in SAP experiment was significantly less (P < 0.05). Salvia miltiorrhizae injection can protect multiple organs of SAP or OJ rats and inhibit the expression of ICAM-1, TLR4, NF-kappaB and regulate Bax proteins. Salvia miltiorrhizae may relieve the inflammation response and enhance the immunity function of SAP and OJ rats.

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Section: Preparation Of Animal Models and Associated Therapeutic Regimenmentioning

confidence: 99%

Section: Preparation Of Animal Models and Associated Therapeutic Regimenmentioning

confidence: 99%

Effects of Salvia Miltiorrhizae on ICAM-1, TLR4, NF-κB and Bax Proteins Expression in Multiple Organs of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Zhang

Liang

et al. 2009

Inflammation

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“…Traditional Chinese medicine (TCM) offers a plethora of treatment options for complex diseases (Zhang et al, 2009;Wang et al, 2010;Efferth and Koch, 2011). Because the efficacy of TCM is based on the combined effects of its constituents, variation in chemical composition between batches of TCM has always been the deterring factor in achieving consistency in efficacy (Gao et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

An approach to optimize the batch mixing process for improving the quality consistency of the products made from traditional Chinese medicines

Yan

2013

J. Zhejiang Univ. Sci. B

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Abstract:The efficacy of traditional Chinese medicine (TCM) is based on the combined effects of its constituents. Variation in chemical composition between batches of TCM has always been the deterring factor in achieving consistency in efficacy. The batch mixing process can significantly reduce the batch-to-batch quality variation in TCM extracts by mixing them in a well-designed proportion. However, reducing the quality variation without sacrificing too much of the production efficiency is one of the challenges. Accordingly, an innovative and practical batch mixing method aimed at providing acceptable efficiency for industrial production of TCM products is proposed in this work, which uses a minimum number of batches of extracts to meet the content limits. The important factors affecting the utilization ratio of the extracts (URE) were studied by simulations. The results have shown that URE was affected by the correlation between the contents of constituents, and URE decreased with the increase in the number of targets and the relative standard deviations of the contents. URE could be increased by increasing the number of storage tanks. The results have provided a reference for designing the batch mixing process. The proposed method has possible application value in reducing the quality variation in TCM and providing acceptable production efficiency simultaneously.

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“…Through decreasing the level of inflammatory mediators, improving microcirculation and removing oxygen free radicals, Salvia miltiorrhizae injection is able to provide a multi-channel, multi-level and multi-link protection against multi-organ damage caused by SAP or OJ [11][12][13][14][15]. Huang XL et al [16] have found that Salvia miltiorrhizae has a protective effect against lung injury occurring during SAP, whereas no reports concerning the protective effect of Salvia miltiorrhizae on the lungs during OJ are seen.…”

Section: Introductionmentioning

confidence: 99%

Effect of Salvia miltiorrhizae on Pulmonary Apoptosis of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Zhang

Chengjun

et al. 2009

Inflammation

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To investigate the effect of apoptosis about Salvia miltiorrhizae injection on the lungs of SAP and OJ rats. Total 288 rats were used for SAP-associated experiments and OJ-associated experiments, respectively. The rats were randomly divided into sham-operated, model control and treated group. According to the difference of time points after operation, the SAP rats in each group were subdivided into 3, 6 and 12 h groups while the OJ rats were divided into 7, 14, 21 and 28 days groups. The pathological changes, expression levels of Bax protein and apoptotic indexes in the lungs of SAP or OJ rats were observed, and the mortality rates of SAP or OJ rats were recorded, respectively. The numbers of dead SAP and OJ rats in treated groups declined. The pathological changes in the lungs of SAP or OJ rats in treated groups were relieved to varying degrees. There was no marked difference in pathological severity scores and the positive staining intensity of Bax protein between treated groups and model control groups (all P > 0.05). Salvia miltiorrhizae has some protective effect on the lungs of rats with SAP or OJ which may be related apoptosis although our results can not find significant difference between treated groups and model control groups.

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Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice

Cited by 10 publications

References 25 publications

Effects of Salvia Miltiorrhizae on ICAM-1, TLR4, NF-κB and Bax Proteins Expression in Multiple Organs of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Effects of Salvia Miltiorrhizae on ICAM-1, TLR4, NF-κB and Bax Proteins Expression in Multiple Organs of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

An approach to optimize the batch mixing process for improving the quality consistency of the products made from traditional Chinese medicines

Effect of Salvia miltiorrhizae on Pulmonary Apoptosis of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

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