Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice

Hsu, Yu‐Wen; Tsai, Chia‐Ying; Chen, Wen‐Kang; Lu, Fung‐Jou

doi:10.1016/j.fct.2009.06.015

Cited by 97 publications

(81 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings demonstrated its protective action on hepatic injury induced by gentamicin. Similarly, treatment with silymarin [23][24] significantly lowered serum cholesterol content in animals received paracetamol or CCl 4 , respectively. The main constituents in cardamom are antioxidants such as tocopherol, phenolic acids, indole-3-carbinol, and volatile organic compounds [25].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Aboubakr

Abdelazem

2015

IJBAS

View full text Add to dashboard Cite

The study was designed to evaluate the hepatoprotective activity of aqueous extract of cardamom in acute experimental liver injury induced by gentamicin. Twenty four male albino rats were randomly divided into four groups (six rats in each). Animals of the first group served as control and orally (p.o.) received (1 ml/kg saline). The second experimental group was given gentamicin (80 mg/kg i.p.) for 7 days. Third and fourth groups were given aqueous extract of cardamom (100 and 200 mg/kg p.o.) + gentamicin for 7 days, respectively. The degree of hepatoprotection was measured using serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. In the acute liver damage induced by gentamicin, cardamom aqueous extracts (100 and 200 mg/kg, p.o.) significantly reduced the elevated serum levels of AST, ALT, bilirubin, cholesterol, triglycerides and low density lipoprotein cholesterol (LDL-chol) in gentamicin induced hepatotoxicity. Also cardamom aqueous extracts (100 & 200 mg/kg, p.o.) significantly increased the lowered serum levels of albumin and high density lipoprotein cholesterol (HDL-chol) in gentamicin induced hepatotoxicity rats. Histopathological examination of the liver tissues supported the hepatoprotection. Our findings concluded that cardamom aqueous extracts possessed hepatoprotective activity against gentamicin induced hepatotoxicity in rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Aboubakr

Abdelazem

2015

IJBAS

View full text Add to dashboard Cite

show abstract

“…As chronic and acute hepatic affections continue to cause severe health problems all over the world, numerous experimental studies have taken considerable interest in the role of natural products such as extract of Coriandrum sativum [15], root of Taraxacum officinale [16], aqueous extract of Coptidis rhizoma [17], extract of Pracparatum mungo (Phaseolus mungo L.) [18], sea buckthorn seed oil (Hippophae rhamnoides L., Elaeagnaceae) [19] and the alga Laminaria japonica [20] in treating hepatic disorders.…”

Section: Introductionmentioning

confidence: 99%

Effect of Apitherapy Formulations against Carbon Tetrachloride-Induced Toxicity in Wistar Rats after Three Weeks of Treatment

Andriţoiu

Ochiuz

Andriţoiu³

et al. 2014

Molecules

View full text Add to dashboard Cite

Abstract:The human body is exposed nowadays to increasing attacks by toxic compounds in polluted air, industrially processed foods, alcohol and drug consumption that increase liver toxicity, leading to more and more severe cases of hepatic disorders. The present paper aims to evaluate the influence of the apitherapy diet in Wistar rats with carbon tetrachloride-induced hepatotoxicity, by analyzing the biochemical determinations (enzymatic, lipid and protein profiles, coagulation parameters, minerals, blood count parameters, bilirubin levels) and histopathological changes at the level of liver, spleen and pancreas. The experiment was carried out on six groups of male Wistar rats. Hepatic lesions were induced by intraperitoneal injection of carbon tetrachloride (dissolved in paraffin oil, 10% solution). Two mL per 100 g were administered, every 2 days, for 2 weeks. Hepatoprotection was achieved with two apitherapy diet formulations containing honey, pollen, propolis, Apilarnil, with/without royal jelly. Biochemical results reveal that the two apitherapy diet formulations have a positive effect on improving the enzymatic, lipid, and protein profiles, coagulation, mineral and blood count parameters and bilirubin levels. The histopathological results demonstrate the benefits of the two apitherapy diet formulations on reducing toxicity at the level of liver, spleen and pancreas in laboratory animals.

show abstract

“…Sea buckthorn seed oil administration was found to attenuate CCl 4 -induced haptic damage in ICR mice, not only reducing the elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALT), but also improving the activities of antioxidant enzymes and liver histopathology [25]. The same preparation was also found to improve liver glutathione, SOD, and catalase, and to reduce hepatic toxicity induced by oxidized LDL in mice [31].…”

Section: Liver Protectionmentioning

confidence: 93%

“…Sea buckthorn fruit feeding alleviated oxidative stressinduced skin damage in mice exposed to UV irradiation [24]. Sea buckthorn seed oil displayed hepatic protection in a carbon chloride induced mice model by improving their antioxidant defense system and suppressing lipid oxidation [25].…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

Hippophae rhamnoides L. 沙棘 (Shaji, Common Sea-buckthorn)

Li¹,

Hu²

2015

Dietary Chinese Herbs

View full text Add to dashboard Cite

The common sea-buckthorn (Hippophae rhamnoides Linnaeus, also known as Elaeagnus rhamnoides (Linnaeus) A. Nelson, or Rhamnoides Hippophae Moench) is a species of flowering plants of the family Elaeagnaceae, native to the dry temperate and cold desert areas of China, Russia, Mongolia, India, Pakistan, Nepal, Europe and North America. Comprising of eight subspecies, sea buckthorn is by far the most widespread species of the genus [1]. The most common subspecies are H.

show abstract

Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice

Cited by 97 publications

References 42 publications

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Effect of Apitherapy Formulations against Carbon Tetrachloride-Induced Toxicity in Wistar Rats after Three Weeks of Treatment

Hippophae rhamnoides L. 沙棘 (Shaji, Common Sea-buckthorn)

Contact Info

Product

Resources

About