Protective effects of sodium selenite supplementation against irradiation-induced damage in non-cancerous human esophageal cells

Puspitasari, Irma Melyani; Yamazaki, Chiho; Abdulah, Rizky; Putri, Mirasari; Kameo, Satomi; Nakano, Takashi; Koyama, Hiroshi

doi:10.3892/ol.2016.5434

Cited by 16 publications

(19 citation statements)

References 28 publications

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“…These different results that were observed, caused by the chosen experimental conditions, may explain the contradictory effects of sodium selenite on the cellular radiation sensitivity described in the literature. There are reports for sodium selenite from radiosensitizing [13,14] to radioprotection [15] to no influence on radiation response [16,17]. On the basis of our results, could not confirm the hypothesis of Schueller and co-worker that sodium selenite in low concentrations (< 5 µM) is radioprotective, while high doses cause radiosensitization [13].…”

Section: Discussioncontrasting

confidence: 79%

“…However, overall, in the further literature, the effects of sodium selenite described on the cellular radiation sensitivity are contradictory. There are reports for sodium selenite from radiosensitizing [13,14] to radioprotection [15]. Furthermore, in several studies no influence of sodium selenite on radiation response was observed [16,17].…”

Section: Introductionmentioning

confidence: 99%

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The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues

2020

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Sodium selenite is often given to moderate the side effects of cancer therapy to enhance the cellular defence of non-cancerous cells. To determine whether sodium selenite during radiotherapy protects not only normal cells but also cancer cells, which would imply a reduction of the desired effect of irradiation on tumour during radiotherapy, the effect of the combined treatment of irradiation and sodium selenite was investigated. Human bronchial cells from carcinoma (A549) and normal tissue (BEAS-2B) were treated with sodium selenite and effects on growth and in combination with radiation on metabolic activity and cell cycle distribution were studied. The influence on radiosensitivity was determined via colony forming assays using different solvents of sodium selenite and treatment schedules. It was shown that sodium selenite inhibits growth and influences cell cycle distribution of both normal and tumour cells. Metabolic activity of normal cells decreased more rapidly compared to that of cancer cells. The influence of sodium selenite on radiation response depended on the different treatment schedules and was strongly affected by the solvent of the agent. It could be shown that the effect of sodium selenite on radiation response is strongly dependent on the respective experimental in vitro conditions and ranges from lead to an initially suspected but ultimately no real radioprotection to radiosensitizing up to no effect in one and the same cell line. This might be a reason for controversially described cell responses to radiation under the influence of sodium selenite in studies so far.

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Section: Discussioncontrasting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues

2020

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“…Another in vitro study revealed that sodium selenite protects human esophagus cells against radiation injury. Selenium increased the viability of cells and reduced apoptosis . These results may indicate the potential protective effect of selenium against side effects of head and neck radiotherapy.…”

Section: Selenium As Radioprotectormentioning

confidence: 72%

“…Selenium increased the viability of cells and reduced apoptosis. 40 These results may indicate the potential protective effect of selenium against side effects of head and neck radiotherapy. In contrast to amifostine, selenium has low toxicity.…”

Section: Selenium As Radioprotectormentioning

confidence: 88%

Selenium as an adjuvant for modification of radiation response

Farhood

Mortezaee

Motevaseli

et al. 2019

J of Cellular Biochemistry

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Ionizing radiation plays a central role in several medical and industrial purposes. In spite of the beneficial effects of ionizing radiation, there are some concerns related to accidental exposure that could pose a threat to the lives of exposed people. This issue is also very critical for triage of injured people in a possible terror event or nuclear disaster. The most common side effects of ionizing radiation are experienced in cancer patients who had undergone radiotherapy. For complete eradication of tumors, there is a need for high doses of ionizing radiation. However, these high doses lead to severe toxicities in adjacent organs. Management of normal tissue toxicity may be achieved via modulation of radiation responses in both normal and malignant cells. It has been suggested that treatment of patients with some adjuvant agents may be useful for amelioration of radiation toxicity or sensitization of tumor cells. However, there are always some concerns for possible severe toxicities and protection of tumor cells, which in turn affect radiotherapy outcomes. Selenium is a trace element in the body that has shown potent antioxidant and radioprotective effects for many years. Selenium can potently stimulate antioxidant defense of cells, especially via upregulation of glutathione (GSH) level and glutathione peroxidase activity. Some studies in recent years have shown that selenium is able to mitigate radiation toxicity when administered after exposure. These studies suggest that selenium may be a useful radiomitigator for an accidental radiation event. Molecular and cellular studies have revealed that selenium protects different normal cells against radiation, while it may sensitize tumor cells. These differential effects of selenium have also been revealed in some clinical studies. In the present study, we aimed to review the radiomitigative and radioprotective effects of selenium on normal cells/tissues, as well as its radiosensitive effect on cancer cells.

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“…145 In the past, Se has shown interesting radioprotective properties as a low toxic and potent antioxidant agent. [146][147][148][149][150] In recent years, Se has also been found to have radiosensitization, 151 and it exhibited a differential effect on the tumor and normal cells. 152 Cruz et al 153 synthesized Se nanoparticles (SeNPs).…”

Section: Reviewmentioning

confidence: 99%