Protective effects of trapidil in lung after abdominal aorta induced ischemia–reperfusion injury: an experimental study

Abstract

Infrarenal abdominal aortic occlusion and reperfusion causes lung injury. We conclude that trapidil has preventive effects in the lung tissue after IR injury.

Lipid emulsion mitigates impaired pulmonary function induced by limb ischemia/reperfusion in rats through attenuation of local cellular injury and the subsequent systemic inflammatory

“…However, investigators have also proved that glutamine can mitigate local injury thereby inhibiting a systemic inflammatory affect. Somuncu et al [8] postulated that Trapidil prevents secondary lung injury induced by IR through its inhibitory action on PMN activation and reducing the levels of malondialdehyde (MDA). Additionally, Wang et al [5] reported that Shenmai can improve secondary lung dysfunction after limb ischemia/reperfusion by attenuating inflammatory and oxidative response.…”

β-Glucan Protects against Lung Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

“…Therefore, lipid peroxidation has been suggested to be closely related to IR-induced tissue injury. MDA is a final product of lipid peroxidation and is widely accepted as a sensitive marker of the rate of lipid peroxidation [1,3,18] We found that the level of MDA significantly increased after aortic IR, which reflects increased lipid peroxidation due to increased oxidative stress. Okutan et al [1] reported that MDA levels increased during lung IR in rats.…”

“…Lung injury induced by aortic IR predisposes to development of acute lung dysfunction, which is still a frequent complication after elective infrarenal abdominal aortic surgery [2]. Lung injury induced by aortic IR is characterized by infiltration of activated leukocytes, increased oxidative stress, microvascular permeability, and systemic inflammatory response [3,4]. Reactive oxygen species (ROS), polymorphonuclear leukocytes, complement system, and endothelial cells are the major cellular and humoral factors that are involved in the mechanisms of IR damage [5].…”

The Effect of Nω-Nitro-l-Arginine Methyl Ester and l-Arginine on Lung Injury Induced by Abdominal Aortic Occlusion–Reperfusion

“…In a similar experimental model, Somuncu et al also reported increased MDA and NO levels in lung after aortic IR. 23 Vascular endothelial growth factor, a homodimeric 32-45 kDa heparin-binding glycoprotein, is a potent angiogenic factor. 14 The expression of VEGF is induced by multiple stimuli including hypoxia, 14,30 reactive oxygen species, 15 and various infl ammatory cytokines, such as tumor necrosis factor-α and interleukin-6.…”

“…Consistent with our fi nding, increased PMN infi ltration have been found in rat lung after aortic IR in several studies. [21][22][23] Lipid peroxidation is an autocatalytic mechanism leading to the oxidative destruction of cellular membranes. 24 Cellular membranes are composed of polyunsaturated fatty acids and phospholipids which are most susceptible to peroxidatic damage.…”