Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity

Mercantepe, Tolga; Kalkan, Yıldıray; Tümkaya, Levent; Şehitoğlu, İbrahim; Mercantepe, Filiz; Yıldırmış, Sermet

doi:10.17219/acem/68967

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…These side effects are thought to be the result of oxidative damage caused by reactive oxygen species. In addition, other toxic effects of MTX are neurotoxicity, pulmonary fibrosis, testicular toxicity, pancreatic toxicity and intestinal mucositis (Mercantepe et al, 2018). There are studies in the literature to prevent hepatotoxicity and nephrotoxicity, which are the most important side effects caused by MTX (Yang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Linoleic Acid on Liver Toxicity Induced By Methotrexate

Kabakçı¹,

Bozkır²

2023

Int. J. Morphol.

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Human hepatocyte cell line (CRL-11233) cells obtained from the American Type Culture Collection Organization (ATCC) were used. Expressions of apoptotic pathway markers, apoptosis inducing factor (AIF), BAX, BCL 2, GADD 153, 78-kDa glucose-regulated protein (GRP78), and CASPASE-3 were evaluated. All analyzes were examined in four groups (Group 1; control, Group 2; linoleic acid given, Group 3; methotrexate given and Group 4; linoleic acid and methotrexate given). The mean ± standard error values of the obtained results as nanogram / milliliter (ng / ml) are in Group I,

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Linoleic Acid on Liver Toxicity Induced By Methotrexate

Kabakçı¹,

Bozkır²

2023

Int. J. Morphol.

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“…These side effects are thought to be the result of oxidative damage caused by reactive oxygen species. In addition, other toxic effects of MTX are neurotoxicity, pulmonary fibrosis, testicular toxicity, pancreatic toxicity and intestinal mucositis [32][33][34]. There are studies in the literature to prevent hepatotoxicity and nephrotoxicity, which are the most important side effects caused by MTX [16,33,34].…”

Section: Discussionmentioning

confidence: 99%

Effect of Methotrexate and Linoleic Acid on BAX/BCL2 Ratio in Human Hepatocyte Cell

Kabakçı

Kaplan

Şingirik

et al. 2021

JPRI

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Aims: To investigate the effect of methotrexate and linoleic acid on BAX/BCL 2 ratio in human hepatocyte cell. Study Design: Original Research Article. Place and Duration of Study: The study was carried out in partnership with the Department of Anatomy and Department of Medical Pharmacology of Çukurova University Faculty of Medicine, using the laboratory facilities of the Department of Medical Pharmacology. Methodology: Human hepatocyte cell line (CRL-11233) cells obtained from the American Type Culture Collection Organization (ATCC) were used. Expressions of apoptotic pathway markers, apoptosis inducing factor BAX, BCL2 and BAX/BCL2 were evaluated. All analyzes were examined in four groups (Group 1; control, Group 2; linoleic acid given, Group 3; methotrexate given and Group 4; linoleic acid and methotrexate given). Results: The mean ± standard error values of the obtained results as nanogram / milliliter (ng / ml) are in Group I, Group II, Group III and Group IV, respectively; BAX values, 0.900 ± 0.1864, 1.002 ± 0.2098, 8.352 ± 1.467 and 4.295 ± 1.522, BCL 2 values, 13.93 ± 1.198, 13.92 ± 1.739, 2.938 ± 1.059 and 9.250 ± 1.492 and BAX/BCL2 values 0.065, 0.072, 2.843 and 0.464. Conclusion: While BAX/BCL2 level increased in the group given methotrexate, it decreased in the group given linoleic acid and methotrexate.

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“…10 Caspase-3 is a cysteine-protease group enzyme that plays an important role during apoptosis and is an important apoptotic marker. 36 Several studies have reported that the amount of caspase-3 in the organism increases significantly after irradiation. 37 Mercantepe et al (2019) suggested that IR activated caspase-3 in renal tubule cells and enhanced the amount of apoptosis.…”

Section: Vacuolization Of Tubular Epithelial Cellsmentioning

confidence: 99%

The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation

et al. 2022

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This study aimed to elucidate the effects of amifostine (ethyol) (AM), a synthetic radioprotector, and red ginseng (RG), a natural radioprotective agent, against the toxic effect of ionizing radiation (IR) on kidney tissues through changes in biochemical and histopathological parameters in addition to contributions to the use of amifostine and RG in clinical studies . Five groups were established: Group I (control, receiving only saline by gavage), Group II (IR only), and Group III (IR+AM, 200 mg/kg intraperitoneally (i.p.). Group IV (IR + RG, 200 mg/kg orally once a day for 4 weeks), and Group V (IR+RG+AM, 200 mg/kg orally once/day for 4 weeks before IR and 200 mg/kg AM administered (i.p.) 30 min before IR). All groups, except for the control group, were subject to 6-Gy whole-body IR in a single fraction. 24 h after irradiation, all animals were sacrificed under anesthesia. IR enhanced MDA, 8-OHdG, and caspase-3 expression while decreasing renal tissue GSH levels ( p < .05). Significant numbers of necrotic tubules together with diffuse vacuolization in proximal and distal tubule epithelial cells were also observed. The examination also revealed substantial brush boundary loss in proximal tubules as well as relatively unusual glomerular structures. While GSH levels significantly increased in the AM, RG, and AM+RG groups, a decrease in KHDS, MDA, 8-OHdG, and caspase-3 expression was observed, compared to the group subject to IR only ( p < .05). Therefore, reactive oxygen species-scavenging antioxidants may represent a promising treatment for avoiding kidney damage in patients receiving radiation.

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Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity

Cited by 8 publications

References 18 publications

Protective Effect of Linoleic Acid on Liver Toxicity Induced By Methotrexate

Protective Effect of Linoleic Acid on Liver Toxicity Induced By Methotrexate

Effect of Methotrexate and Linoleic Acid on BAX/BCL2 Ratio in Human Hepatocyte Cell

The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation

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