Protective efficacy of ellagic acid on glycoproteins, hematological parameters, biochemical changes, and electrolytes in myocardial infarcted rats

Maharajan, Mari Kannan; Quine, S. Darlin; Sangeetha, T.

doi:10.1002/jbt.21418

Cited by 23 publications

(11 citation statements)

References 23 publications

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“…modified various biochemical parameters, including serum iron, plasma iron binding capacity, uric acid, glycoprotein, and electrolytes. It also returned the various hematological parameters to near normal levels, down from the increased levels brought on by the administration of isoproterenol (100 mg/kg, 2 d) [216]. Using the same doses, administration method, and experimental protocols, these authors also described ellagic acidʼs protective effects against isoproterenol-induced arrhythmias, hypertrophy, and lipid peroxidation during myocardial infarction in rats [217].…”

Section: Cardiovascular Effectsmentioning

confidence: 87%

A Pharmacological Update of Ellagic Acid

et al. 2018

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Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is present either in free form or as part of more complex molecules (ellagitannins), which can be metabolized to liberate ellagic acid and several of its metabolites, including urolithins. While ellagic acidʼs antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-α, interleukin-1β, interleukin-6), and decrease the activity of nuclear factor-κB while increasing nuclear factor erythroid 2-related factor 2 expression. These events play an important role in ellagic acidʼs anti-atherogenic, anti-inflammatory, and neuroprotective effects. Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. In addition, results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a potential anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis and its aforementioned anti-inflammatory properties. Taken together, these effects make ellagic acid a highly interesting compound that may contribute to different aspects of health; however, more studies are needed, especially on the compoundʼs pharmacokinetic profile. In this review, we selected papers published from 2005 to the present.

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Section: Cardiovascular Effectsmentioning

confidence: 87%

A Pharmacological Update of Ellagic Acid

et al. 2018

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“…As it is a polyphenol compound (carrying four OH groups) it could scavenge iron raised by irradiation. EA at dose of 15 mg/kg returned serum iron and TIBC near to normal levels in myocardial infracted rats (Kannan et al, 2012). Moreover, supplementation of irradiated rats with ZA ameliorated the changes in serum iron, TIBC and transferrin disturbed by γ-irradiation.…”

Section: Discussionmentioning

confidence: 81%

Ellagic Acid and Zinc Aspartate Ameliorate Gamma Radiation Induced Biochemical Alterations in Male Rats

2013

Egypt. J. Rad.Sci.

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“…Toxicological properties of a supplement is determined in terms of blood hematological parameters (Kannan et al, 2012). Results revealed no significant ( p < 0.05) effects on the hemoglobin concentration except in OPO2 group, which showed an increase level.…”

Section: Discussionmentioning

confidence: 99%

Changes in Acylglycerols Composition, Quality Characteristics and In vivo Effects of Dietary Pumpkin Seed Oil upon Thermal Oxidation

Zeb

Ahmad

2017

Front. Chem.

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This study was aimed to determine the acylglycerols composition, quality characteristics, and protective role of dietary pumpkin seed oil (PSO) in rabbits. PSO was thermally oxidized and analyzed for quality characteristics and acylglycerols composition using reversed phase high performance liquid chromatography with diode array detection (HPLC-DAD). Oxidized and un-oxidized oil samples were fed to the rabbits in different doses for 2 weeks. The changes in the serum biochemistry, hematology, and liver histology were studied. The levels of quality parameters such peroxide value (PV), anisidine value (AV), total phenolic contents (TPC), thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and conjugated trienes (CT) significantly increased with thermal treatment. HPLC analyses revealed 10 individual triacylglycerols (TAGs), total di-acylglycerols (DAGs), mono-acylglycerols (MAGs), and total oxidized TAGs. Trilinolein (LLL), 1-oleoyl-2,3-dilinolinoyl glycerol (OLL), triolein (OOO) and 1,2-distearoyl-3-palmitoyl glycerol (SSP) were present in higher amounts and decreased with thermal treatment. Animal's studies showed that oxidized oils decreased the whole body weight, which was ameliorated by the co-administration of un-oxidized oils. The levels of serum biochemical parameters were improved by co-administration of pumpkin seed oils. There were no significant effects of both oxidized and un-oxidized PSO on the hematological and histological parameters of rabbits. In conclusion, nutritionally important triacylglycerols were present in PSO with protective role against the toxicity of its corresponding oxidized oils.

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Protective efficacy of ellagic acid on glycoproteins, hematological parameters, biochemical changes, and electrolytes in myocardial infarcted rats

Cited by 23 publications

References 23 publications

A Pharmacological Update of Ellagic Acid

A Pharmacological Update of Ellagic Acid

Ellagic Acid and Zinc Aspartate Ameliorate Gamma Radiation Induced Biochemical Alterations in Male Rats

Changes in Acylglycerols Composition, Quality Characteristics and In vivo Effects of Dietary Pumpkin Seed Oil upon Thermal Oxidation

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