Protective immunity against malaria: cellular changes in the liver vary according to the method of immunization

Fauré, Patrick; Hulier, Elisabeth; Miltgen, F; Rénia, Laurent; Mazier, Dominique

doi:10.1111/j.1365-3024.1995.tb00917.x

Cited by 5 publications

(1 citation statement)

References 36 publications

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“…It is only recently that studies of liverresident lymphocytes during liver stage development have been undertaken (61)(62)(63). Immunization with γ-spz induced hepatic lymphocytes to undergo blast transformation with an expansion of CD3 + CD8 + T cells, but the numbers of these cells decreased in livers of mice subsequently challenged with P. berghei sporozoites (62).…”

Section: Mechanisms Of Protective Immunity To Liver Stage Parasitesmentioning

confidence: 99%

Immunity to Liver Stage Malaria: Considerations for Vaccine Design

Taylor‐Robinson

2003

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Malaria is the world's deadliest parasitic disease and effective control measures are a public health priority. Most deaths in humans from malaria are caused by one species of the protozoa, Plasmodium falciparum. An efficacious and cost-effective vaccine against this parasite is considered a holy grail of modern molecular medicine. A vaccine that targets liver stage parasites would prevent infection from reaching the blood and causing clinical disease. Among known P. falciparum antigens, liver stage antigen-1 (LSA-1) is the only protein expressed exclusively by infected hepatocytes. Several independent studies in humans have consistently related immune responses to LSA-1 with resistance to infection or disease, providing a powerful rationale for the development of liver stage vaccines. Investigations by ourselves and others aim to dissect the mechanism of cellular immunity to LSA-1 and to evaluate in different delivery systems epitopes associated with protection as components of a multiantigen malaria vaccine. The first clinical trials are already being conducted, the results of which are eagerly awaited.

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Section: Mechanisms Of Protective Immunity To Liver Stage Parasitesmentioning

confidence: 99%

Immunity to Liver Stage Malaria: Considerations for Vaccine Design

Taylor‐Robinson

2003

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Dendritic cells and the malaria pre-erythrocytic stage

et al. 2012

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Malaria remains one of the main infectious diseases in intertropical regions. The malaria parasite has a complex life cycle in its mammalian host, switching between variable forms as it traverses through different tissues and anatomic locations, either intra- or intercellularly. During its journey, the parasite encounters and interacts with the host immune system, which functions to prevent infections and limit ensuing pathologies. One important component of the host immune system is the dendritic cells (DC) network. DC form a heterogeneous group of pathogen-sensing and antigen-presenting cells that play a crucial role in the initiation of adaptive immunity. Here, we review the known and unknown interactions between the malaria parasites and the DC system, starting from the inoculation of the parasite in the skin up to its exit from the liver, also known as the pre-erythrocytic stage of the infection, and discuss how deciphering these interactions may contribute to our understanding of the Plasmodium parasite biology as well as to the induction of immune protection via vaccination.

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