Protective mechanisms against oxidative stress and angiopathy in young patients with diabetes type 1 (DM1)

Koutroumani, Nikolitsa; Partsalaki, Ioanna; Lamari, Fotini N.; Dettoraki, Athina; Gil, Andrea Paola Rojas; Karvela, Alexia; Kostopoulou, Eirini; Spiliotis, Bessie E.

doi:10.1515/jpem-2012-0183

Cited by 6 publications

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“…These findings may suggest a counter-regulatory action of the antioxidant markers in an attempt to protect against the glucose-mediated oxidative stress during the OGTT in obese children with IGT. This has been described in young patients with type 1 diabetes mellitus (DM1) [53]. Furthermore, a negative correlation between insulin and Apo1fas response curves was noted in children with IGT, which is in agreement with the finding that the Apo1fas AUC was negatively correlated with insulin in these children.…”

Section: Discussionsupporting

confidence: 87%

The Response of Antioxidant Enzymes and Antiapoptotic Markers to an Oral Glucose Tolerance Test (OGTT) in Children and Adolescents with Excess Body Weight

Katsa,

Kostopoulou,

Nomikos

et al. 2023

IJMS

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Oxidative stress and apoptosis are involved in the pathogenesis of obesity-related diseases. This observational study investigates the antioxidant and apoptotic markers response to an oral glucose tolerance test (OGTT) in a population of overweight children and adolescents, with normal (NGT) or impaired glucose tolerance (IGT). Glucose, insulin, and C-peptide concentrations, as well as oxidative stress (SOD, GPx3) and apoptotic markers (Apo1fas, cck18), were determined at T = 0, 30, 60, 90, 120, and 180 min after glucose intake during OGTT. The lipid profile, thyroid function, insulin-like growth factor1, leptin, ghrelin, and adiponectin were also measured at baseline. The 45 participants, with a mean age of 12.15 (±2.3) years old, were divided into two subcategories: those with NGΤ (n = 31) and those with IGT (n = 14). The area under the curve (AUC) of glucose, insulin, and C-peptide was greater in children with IGT; however, only glucose differences were statistically significant. SOD and GPx3 levels were higher at all time points in the IGT children. Apo1fas and cck18 levels were higher in the NGT children at most time points, whereas Adiponectin was lower in the IGT group. Glucose increased during an OGTT accompanied by a simultaneous increase in antioxidant factors, which may reflect a compensatory mechanism against the impending increase in oxidative stress in children with IGT.

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Section: Discussionsupporting

confidence: 87%

The Response of Antioxidant Enzymes and Antiapoptotic Markers to an Oral Glucose Tolerance Test (OGTT) in Children and Adolescents with Excess Body Weight

Katsa,

Kostopoulou,

Nomikos

et al. 2023

IJMS

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“…The TBARS marker has been identified at increased levels in the serum of adult patients with DM2, 28 and with diabetic neuropathy. 29 Similarly, elevated MDA concentrations have also been found in children with DM1 and microalbuminuria by our group 30 and in patients with DM1 and DM2 by others. 31 Given that our markers PrMDA and PrTBARS both measure aldehydes of lipid peroxidation origin (with PrMDA measuring specifically the aldehyde MDA), their molar sum is a more representative marker of lipid peroxidized protein-associated DM1.…”

Section: Discussionsupporting

confidence: 73%

Oxidized lipid‐associated protein damage in children and adolescents with type 1 diabetes mellitus: New diagnostic/prognostic clinical markers

et al. 2021

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Background: Type 1 diabetes mellitus (DM1), a chronic metabolic disorder of autoimmune origin, has been associated with oxidative stress (OS), which plays a central role in the onset, progression, and long-term complications of DM1. The markers of OS lipid peroxidation products, lipid hydroperoxides (LOOH), and also malondialdehyde (MDA) and thiobarbituric reactive substances (TBARS) that oxidatively modify proteins (Pr) (i.e., PrMDA and PrTBARS, respectively), have been associated with DM2, DM1, diabetic neuropathy, and microalbuminuria.Objective/Subjects: Here, we investigated LOOH, PrMDA and PrTBARS in 50 children and adolescents with DM1 and 21 controls. Results:The novel OS marker PrTBARS was assessed for the first time in children and adolescents with DM1. LOOH and the pair PrMDA/PrTBARS, representing early and late peroxidation stages, respectively, are found to be significantly higher (130%, 50/90%, respectively, at p < 0.001) in patients with DM1 compared to controls. The studied OS parameters did not differ with age, age at diagnosis, sex, duration of DM1, presence of recent ketosis/ketoacidosis, or mode of treatment. Conclusions:We propose that LOOH, PrMDA and the new marker PrTBARS could serve as potential diagnostic clinical markers for identifying OS in children and adolescents with DM1, and may, perhaps, hold promise as a prognostic tool for future complications associated with the disease.

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The role of carbohydrate counting in glycemic control and oxidative stress in patients with type 1 diabetes mellitus (T1DM)

et al. 2020

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Protective mechanisms against oxidative stress and angiopathy in young patients with diabetes type 1 (DM1)

Abstract: The increased esRAGE and FRAP with increased levels of CML and MDA possibly reflects a protective response against the formation of diabetic complications in these young diabetic patients.

Cited by 6 publications

References 0 publications

The Response of Antioxidant Enzymes and Antiapoptotic Markers to an Oral Glucose Tolerance Test (OGTT) in Children and Adolescents with Excess Body Weight

The Response of Antioxidant Enzymes and Antiapoptotic Markers to an Oral Glucose Tolerance Test (OGTT) in Children and Adolescents with Excess Body Weight

Oxidized lipid‐associated protein damage in children and adolescents with type 1 diabetes mellitus: New diagnostic/prognostic clinical markers

The role of carbohydrate counting in glycemic control and oxidative stress in patients with type 1 diabetes mellitus (T1DM)

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