Protective Mechanisms of Experimental Vaccine-Induced Immunity to &lt;i&gt;Pseudomonas aeruginos&lt;/i&gt;&lt;i&gt;a&lt;/i&gt;

Lieberman, Michael M.

doi:10.1159/000156983

Cited by 1 publication

(2 citation statements)

References 35 publications

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“…used as potential P. aeruginosa vaccines. These include LPS [4], endotoxin protein [5], exotoxin [6] 'slime' polysaccharides [7] 'slime' glycolipoprotein [8], cell wall extracts [9], membrane proteins [10], proteoids (protease-elastase) [11], flagella [12], pill [13] and ribosomal [3] as well as other preparations [1][2][3]. Most of these preparations were found to significantly reduce the incidence of animal mortality due to Pseudomonas infection, some of them without and others with visible deleterious side-effects [1][2][3] as well as varying degrees of success in coping with the variability of the serotypes involved in the Pseudomonas infections [1-31.…”

Section: Various Antigenic Preparations Have Beenmentioning

confidence: 99%

“…Despite the availability of potent antibiotics, the mortality from Pseudomonas aeruginosa infections remains a major medical problem due to the multiple drug resistance of this bacterium [1]. Since certain individuals have an essentially high risk for infection with Pseudomonas, there is a growing interest in the development of a vaccine against it [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Immunization of mice against various strains of Pseudomonas aeruginosa by using Pseudomonas lectin vaccine

Sudakevitz

Gilboa‐Garber

1987

FEMS Microbiology Letters

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The ability of Pseudomonas aeruginosa purified lectin vaccine to protect ICR mice against lethal infection caused by various serotypes of this bacterium was examined. Intraperitoneal injection of the lectin preparation was effective in full protection of the mice against the homologous strain. It was also effective in conferring from a partial to a full protection against most of the other virulent strains tested. The only strain which was still lethal for the immunized mice was one which produces exotoxin A but not lectins.

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